Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 September 2026 | Viewed by 1448
Special Issue Editors
Interests: genetics; epigenetics; medical biochemistry; metabolic disorders
Special Issues, Collections and Topics in MDPI journals
Interests: (clinical) biochemistry; medicinal chemistry; drug discovery; anticancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic syndrome (syndrome X, insulin resistance syndrome) is a multifactorial disease, with higher morbidity and mortality risk and increased frequency in younger people. It includes a cluster of risk factors for cardiovascular diseases caused by adipose tissue dysfunction and insulin resistance. Risk factors most closely tied to metabolic syndrome include age, ethnicity, a body mass index greater than 25, a personal or family history of diabetes, smoking, stress, post-menopausal status, high-fat diet, a sedentary lifestyle, and hormonal imbalance. Genetic factors could influence each individual component of the syndrome and the syndrome itself. The genetic components of hypertension, obesity, dyslipidemia, oxidative stress, inflammation, cytokine hypersecretion, and epigenetic modifications should also be considered in metabolic syndrome risk factors.
According to the National Heart, Lung, and Blood Institute (NHLBI), and the American Heart Association (AHA), metabolic syndrome is diagnosed when a patient has at least three of the following five conditions: abdominal obesity, hypertension, hyperglycemia, hypertriglyceridemia, and a lower HDL-cholesterol level.
Metabolic syndrome greatly raises the risk of developing coronary heart disease, stroke, diabetes, fatty liver, polycystic ovarian syndrome, cholesterol gallstones, asthma, sleep problems, and several types of cancer.
This Special Issue will include original research, case reports, and review papers investigating the biochemical, genetic, and epigenetic biomarkers related to the risk of developing metabolic syndrome in order to elucidate the pathogenic mechanism. Furthermore, it will consider in silico, experimental in vitro, and in vivo studies with higher potential to improve the management (prevention, diagnosis, and treatment) of metabolic syndrome.
Prof. Dr. Lucia Maria Procopciuc
Prof. Dr. Roxana Liana Lucaciu
Guest Editors
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Keywords
- insulin resistance
- hypertension
- diabetes mellitus
- obesity
- inflammation
- stress
- metabolic disorders
- reproductive endocrine disorders
- polycystic ovarian syndrome
- waist circumference
- estrogen deficiency
- disturbances in adipose tissue
- physical inactivity
- overnutrition
- cardiovascular diseases
- abdominal obesity
- genetics and epigenetics of metabolic syndrome
- computational analysis
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