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Reproductive Diseases and Modern Lifestyle: From Bench to Bedside

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 699

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Guest Editor
2nd Department of Obstetrics and Gynaecology, Aretaieio Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Interests: metabolism; obesity; appetite axis; endometrial environment
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Special Issue Information

Dear Colleagues,

Reproduction is one of the most important concepts in biology. It is the process by which plants and animals give rise to offspring. Sexual reproduction is common in multicellular eukaryocytes such as animals. According to the WHO, infertility is a disease of the male and female reproductive systems defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. Approximately one in six couples are affected by infertility globally. Infertility is expected to increase in the future. According to the Centers for Disease Control and prevention, there used to be a worldwide average of five children per woman in 1950; however, according to the United Nations, this has fallen to two children in 2020.

Furthermore, modern life is characterised by environmental pollution, stress, an unhealthy diet, and a rise in metabolic diseases such obesity and type 2 diabetes. In addition, it has been found that the annual production of plastics which contain endocrine disrupting chemicals (EDCs) has grown significantly. Studies have shown the connection between EDCs and infertility. EDCs interfere with the normal function of hormonal systems. All of the above have been connected with reproduction problems and therefore action for a better understanding of pathophysiological mechanisms and treatment is needed.

We call for manuscripts studying the connection between modern lifestyle factors such as stress, EDCs, unhealthy diet/nutrients, and metabolic diseases with reproductive diseases in men and women. Specifically, there is a need for studies connecting all the above lifestyle risk factors with all aspects of the reproductive diseases affecting the male and female reproductive systems. Pathophysiology, mechanisms, and treatment options from bench to bedside will be considered.

Dr. Georgios Valsamakis
Guest Editor

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Keywords

  • infertility
  • endocrine disrupting chemicals
  • reproductive hormones
  • lifestyle
  • metabolic diseases

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Published Papers (1 paper)

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Review

13 pages, 689 KiB  
Review
Obesity- and High-Fat-Diet-Induced Neuroinflammation: Implications for Autonomic Nervous System Dysfunction and Endothelial Disorders
by Galateia Stathori, Nikolaos F. Vlahos, Evangelia Charmandari and Georgios Valsamakis
Int. J. Mol. Sci. 2025, 26(9), 4047; https://doi.org/10.3390/ijms26094047 - 25 Apr 2025
Viewed by 204
Abstract
Obesity is a multifactorial condition linked to severe health complications, including cardiovascular diseases and endothelial dysfunction. Both obesity and high-fat diets (HFDs) are strongly associated with neuroinflammation, particularly in the hypothalamus. The autonomic nervous system (ANS), which controls involuntary physiological processes, is critical [...] Read more.
Obesity is a multifactorial condition linked to severe health complications, including cardiovascular diseases and endothelial dysfunction. Both obesity and high-fat diets (HFDs) are strongly associated with neuroinflammation, particularly in the hypothalamus. The autonomic nervous system (ANS), which controls involuntary physiological processes, is critical for maintaining cardiovascular health, and its dysfunction is implicated in endothelial disorders. With its homeostatic control centers located in the hypothalamus and brainstem, a crucial question arises: could obesity- and HFD-induced neuroinflammation disrupt central ANS structures, leading to ANS dysfunction and subsequent endothelial disorders? This review examined whether neuroinflammation caused by obesity and HFD contributes to endothelial dysfunction through the dysregulation of the ANS. Our analysis revealed that hypothalamic inflammation linked to obesity and an HFD is associated with sympathetic hyperactivity and endothelial disorders. Identified molecular mechanisms include the influence of inflammatory cytokines, activation of the NF-κB/IKK-β pathway, microglial activation mediated by angiotensin II, circulating mitochondria triggering cGAS activation, and the stimulation of the TLR4 pathway. Our findings suggest that hypothalamic inflammation may play a central role in the interplay between obesity/an HFD, ANS dysfunction, and endothelial disorders. Full article
(This article belongs to the Special Issue Reproductive Diseases and Modern Lifestyle: From Bench to Bedside)
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