Musculoskeletal Physiology: Mechanical Stimulation, Mechanical Disuse and Hormone Signaling
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 October 2025) | Viewed by 283
Special Issue Editor
Special Issue Information
Dear Colleagues,
Since the publication of Wolff’s Law in 1892, it has been recognized that the mechanical environment of tissues is a critical factor in homeostasis and their development. Changes in the mechanical environment, the extracellular matrix composition and hormone levels influence cell signaling pathways, and have an influence at the tissue, cellular and molecular levels. These cell signaling responses, which fall under the category of mechanotransduction, are seen in all of the tissue and cell types in the musculoskeletal system, including the muscle, bone, ligaments, tendons, cartilage and adipose tissue. Each of these tissues is also impacted by changes in hormone signaling—for example, estrogen receptors play critical roles in bone and cartilage mechanotransduction response, and multiple hormones influence the production of collagen and other extracellular matrix proteins. This Special Issue will focus on the tissue-, cell-, and molecular-level response of the musculoskeletal system to mechanical stimulation and/or disuse, and the influence of hormonal signaling in these tissues. We welcome papers that look at the influence of mechanical stimuli changes and hormonal signals in muscle, bone, ligaments, tendon, cartilage and adipose tissue. Special consideration will be given to papers that look at the intersection of mechanical and hormonal signaling in these systems.
Dr. Whitney A. Bullock
Guest Editor
Manuscript Submission Information
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Keywords
- mechanotransduction
- musculoskeletal
- hormonal signaling
- muscle–bone crosstalk
- mechanical stimuli
- mechanical disuse
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