Myocardial Infarction: Prevention and Treatment

Dear Colleagues,

Cardiovascular diseases are the leading cause of death globally, and this record is linked to a number of risk factors that, acting alone or in integrated way, are responsible for the development and progression of atherothrombotic disease and its complications. Ischemic heart disease is also considered a complex disease as it is conditioned by both environmental factors and multiple genetic influences. Despite significant improvements over the past decades, acute myocardial infarction remains a major cause of mortality and morbidity and a major source of expense for the National Health System. This is partly due to the multiple presentation modes of myocardial infarction (STEMI, NSTEMI, MINOCA, Tako Tsubo, etc.) which affect the different methods of prevention and treatment. Mechanical reopening of the occluded coronary artery through percutaneous coronary intervention is the main and most effective intervention to restore coronary flow, myocardial perfusion and, consequently, decrease the extent of the infarction. Pharmacological treatment for myocardial infarction is a complex decision and still much debated especially for its duration. However, all this is valid only in the case of a coronary thrombotic occlusion; in fact, there are many cases of myocardial infarction in non-obstructive coronary artery disease (MINOCA) which require a different therapeutic approach.

The correct understanding of the pathophysiological, clinical, and therapeutic mechanisms would therefore be necessary to increase both mortality and morbidities of the patients as well as their quality of life.

The aim of this Special Issue is to offer the readers the best overview about prevention and treatment of myocardial infarction in its many ways in order to give a global and complete vision of the problem.

Dr. Saverio Muscoli
Dr. Marco Alfonso Perrone
Guest Editors

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