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Special Issue "The Early Epigenetic Determinants of Social Stress and Emotion Regulation in Young Infants and Children"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 1828

Special Issue Editors

Dr. Livio Provenzi
E-Mail Website
Guest Editor
Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy
Interests: behavioral epigenetics; developmental psychobiology; early intervention; mother-infant interaction; stress regulation
Special Issues, Collections and Topics in MDPI journals
Dr. Serena Grumi
E-Mail Website
Assistant Guest Editor
Developmental Psychobiology Lab, IRCCS Mondino Foundation, 27100 Pavia, Italy
Interests: behavioral epigenetics; developmental psychobiology; early intervention; mother-infant interaction; stress regulation, risk and protective factors in child development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in developmental psychobiology and behavioral epigenetics suggest that early experiences are crucial in shaping stress regulation, socio-emotional, and socio-cognitive development in infants and children. Early experiences—especially those occurring during the first thousand days after conception—may get under the skin and have a profound impact on the developing biology (e.g., DNA methylation, microRNA, mitochondria regulation, programming of the HPA axis, and telomere regulation) and phenotype (e.g., stress regulation, behavior regulation, socio-emotional skills, and socio-cognitive outcomes) of the offspring. Notably, both adverse and protective early experiences may associate with such long-lasting biomarkers and they may be involved in setting the long-term programming of behavioral, socio-emotional, and socio-cognitive developmental trajectories involved in stress regulation skills. Papers addressing these topics are invited for this Special Issue. We welcome studies involving human subjects and/or animal models. Different manuscript types will be considered, according to the journal guidelines.

Dr. Livio Provenzi
Dr. Serena Grumi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Behavioral epigenetics
  • DNA methylation
  • Emotion regulation
  • Life adversity
  • microRNA
  • Parenting
  • Social cognition
  • Stress
  • Telomere regulation
  • Trauma

Published Papers (1 paper)

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Research

Article
Exploring the Contribution of Proximal Family Risk Factors on SLC6A4 DNA Methylation in Children with a History of Maltreatment: A Preliminary Study
Int. J. Environ. Res. Public Health 2021, 18(23), 12736; https://doi.org/10.3390/ijerph182312736 - 02 Dec 2021
Cited by 1 | Viewed by 1216
Abstract
The cumulative effects of proximal family risk factors have been associated with a high number of adverse outcomes in childhood maltreatment, and DNA methylation of the serotonin transporter gene (SLC6A4) has been associated with child maltreatment. However, the relationships between proximal [...] Read more.
The cumulative effects of proximal family risk factors have been associated with a high number of adverse outcomes in childhood maltreatment, and DNA methylation of the serotonin transporter gene (SLC6A4) has been associated with child maltreatment. However, the relationships between proximal family risk factors and SLC6A4 methylation remains unexplored. We examined the association among cumulative family risk factors, maltreatment experiences and DNA methylation in the SLC6A4 gene in a sample of 33 child victims of maltreatment. We computed a cumulative family risk (CFR) index that included proximal family risk factors, such as drug or alcohol abuse, psychopathology, parents’ experiences of maltreatment/abuse in childhood, criminal history, and domestic violence. The majority of children (90.9%) experienced more than one type of maltreatment. Hierarchical regression models suggested that the higher the CFR index score and the number of maltreatment experiences, and the older the children, the higher the SLC6A4 DNA methylation levels. Although preliminary, our findings suggest that, along with childhood maltreatment experiences per se, cumulative proximal family risk factors are seemingly critically associated with DNA methylation at the SLC6A4 gene. Full article
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