Biofunctional Hydrogels for Tissue Engineering and Regenerative Medicine

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1069

Special Issue Editors

School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
Interests: wound healing; hydrogel scaffold; stem cells; growth factor; drug delivery

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Guest Editor
Manchester Institute of Biotechnology, University of Manchester, Manchester, UK
Interests: peptide self-assembly; rheology; structure-property relationships; hydrogels; cell culture; tissue engineering; drug delivery
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Special Issue Information

Dear Colleagues,

Biofunctional hydrogels, composed of biopolymers or synthetic polymers, have unique properties that make them ideal candidates for tissue engineering and regenerative medicine applications. These hydrogels can be crosslinked to form a three-dimensional network that mimics the extracellular matrix and can incorporate bioactive molecules to enhance tissue regeneration. Biofunctional hydrogels have been extensively investigated for various regenerative medicine applications and have been shown to support cell adhesion, proliferation, and differentiation, as well as regulate cell behavior, angiogenesis, and immune responses. This Special Issue invites original research articles and reviews on the design, fabrication, and application of biofunctional hydrogels for tissue engineering and regenerative medicine. It aims to provide a comprehensive overview of recent advances and challenges in the field, including their biocompatibility, mechanical properties, degradation behavior, and in vitro and in vivo performance, highlighting the potential of biofunctional hydrogels as a versatile platform for regenerative medicine.

Dr. Qian Xu
Prof. Dr. Aline Miller
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • wound healing
  • hydrogel scaffold
  • stem cells
  • tissue engineering
  • drug delivery

Published Papers (1 paper)

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Research

13 pages, 4565 KiB  
Article
Tissue Regeneration with Gelatine/Polysaccharide Derived Hydrogel Scaffolds: From Formulation to In Vivo Efficacy
by Jing Li, Keying He and Qian Xu
Gels 2023, 9(9), 744; https://doi.org/10.3390/gels9090744 - 13 Sep 2023
Viewed by 865
Abstract
Combinations of different biomaterials with certain formulations may lead to improved properties and have significant potential for use in tissue regeneration applications. However, previously reported studies comparing biomaterials often suffered from inconsistent processing methods or inadequate comprehensive application research, hindering a comprehension of [...] Read more.
Combinations of different biomaterials with certain formulations may lead to improved properties and have significant potential for use in tissue regeneration applications. However, previously reported studies comparing biomaterials often suffered from inconsistent processing methods or inadequate comprehensive application research, hindering a comprehension of their efficacy in tissue engineering. This report explores the significance of screening the combination of gelatine with polysaccharide materials, specifically hyaluronic acid (HA) and carboxymethyl cellulose (CMC), using the same crosslinking method used for tissue regeneration. Hydrogel scaffolds (Gel/HA and Gel/CMC) at various concentrations were developed and characterized to assess their physiochemical properties. The results demonstrated that the hydrogels exhibited desirable mechanical properties, appropriate swelling behaviour, suitable porosity, and excellent cytocompatibility. In particular, the Gel1HA1 and Gel1CMC1 hydrogels showed remarkable cellular proliferation and aggregation. Further, we performed animal studies and explored the tissue regeneration effects of the Gel1HA1 and Gel1CMC1 hydrogels. Both hydrogels exhibited an accelerated wound closure rate and promoted vessel formation in a rodent full-thickness skin excisional model. Additionally, the subcutaneous implantation model demonstrated the induction of angiogenesis and collagen deposition within the implanted hydrogel samples. Overall, the hydrogels developed in this study demonstrated promising potential for use in the regeneration of soft tissue defects and this study emphasizes the significance of screening biomaterial combinations and formulations for tissue regeneration applications. Full article
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