Aquaculture Pharmacology

A special issue of Fishes (ISSN 2410-3888). This special issue belongs to the section "Welfare, Health and Disease".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 325

Special Issue Editor


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Guest Editor
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Interests: pharmacokinetics; pharmacodynamics; pharmacokinetic/pharmacodynamic model; tissue distribution; withdrawal time; risk assessment; fish
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Special Issue Information

Dear Colleagues,

This Special Issue aims to serve as a platform for cutting-edge research that spans therapeutic applications in aquaculture while addressing the unintended consequences of drug exposure in aquatic animal populations.

The scope of this Special Issue includes, but is not limited to, the following:

  1. Evaluations of the therapeutic efficacy of antibiotics, antiparasitic agents, antifungals, and other drugs in aquaculture settings.
  2. In-depth pharmacokinetic studies unraveling the dynamics of drug absorption, distribution, metabolism, and excretion in aquatic animals.
  3. Residue depletion studies specific to aquatic medicine, enhancing our understanding of the persistence and potential environmental impact of pharmaceuticals.
  4. Explorations of the unintended consequences of drug exposure in aquatic animal populations and their ecological implications.
  5. Strategies and innovations for mitigating the ecological footprint of pharmaceuticals in aquatic environments.

I look forward to receiving your contributions.

Kind Regards,

Prof. Dr. Fan Yang
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fishes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacokinetics
  • pharmacodynamics
  • withdrawal time
  • risk assessment
  • residue depletion
  • therapeutic efficacy
  • antibiotics in aquaculture
  • antiparasitic agents in aquaculture
  • aquatic medicine
  • aquaculture pharmacology

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Published Papers (1 paper)

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Research

17 pages, 1779 KiB  
Article
Effect of Berberine Hydrochloride on Disposition Characteristics of Ciprofloxacin Hydrochloride and Its Mechanism in Yellow Catfish (Pelteobagrus fulvidraco) Following Combined Oral Administration
by Tianfu Zhong, Xiangxuan Du, Yueyan Chen and Yongtao Liu
Fishes 2025, 10(6), 245; https://doi.org/10.3390/fishes10060245 - 23 May 2025
Abstract
To investigate the effects and underlying mechanisms of the Chinese herbal medicine berberine hydrochloride (BBH) on the pharmacokinetics of the antibiotic ciprofloxacin hydrochloride (CIP) in yellow catfish (Pelteobagrus fulvidraco), this study established two experimental groups: CIP alone and CIP combined with [...] Read more.
To investigate the effects and underlying mechanisms of the Chinese herbal medicine berberine hydrochloride (BBH) on the pharmacokinetics of the antibiotic ciprofloxacin hydrochloride (CIP) in yellow catfish (Pelteobagrus fulvidraco), this study established two experimental groups: CIP alone and CIP combined with BBH. After administering the two treatment groups, we analyzed the pharmacokinetic characteristics and tissue distribution of CIP in yellow catfish, as well as the differences in the expression levels of two key genes involved in drug disposition—ABCB4 (ATP-binding cassette subfamily B member 4, related to drug transport) and CYP3A40 (cytochrome P450 3A40, related to drug metabolism)—in the intestinal tract. The results demonstrated that co-administration of CIP and BBH increased the maximum concentration (Cmax) and area under the concentration–time curve (AUC) of CIP while reducing its total body clearance (CL/F). Regarding gene expression, the combined treatment significantly downregulated ABCB4 expression in the intestine at certain time points compared to CIP alone, whereas CYP3A40 expression showed a non-significant decreasing trend. These findings suggest that BBH may enhance the absorption of CIP in yellow catfish by suppressing ABCB4 expression, thereby improving therapeutic efficacy at the same dosage. Full article
(This article belongs to the Special Issue Aquaculture Pharmacology)
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