Aquatic Organisms in Toxicology and Environmental Health

A special issue of Fishes (ISSN 2410-3888). This special issue belongs to the section "Environment and Climate Change".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 706

Special Issue Editor


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Guest Editor
College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China
Interests: zebrafish; developmental toxicity; neurotoxicity; cardiotoxicity; genotoxicity; oxidative damage

Special Issue Information

Dear Colleagues,

Aquatic systems, serving as ultimate sinks, have been receiving discharges from domestic and industrial wastewaters. Given that some rivers and lakes are utilized as water supplies, this poses significant threats to human health. Effective water quality control and management are essential for safeguarding the health of both ecosystems and human populations. While physical and chemical indices can provide information on pollutants, they do not fully capture the potential synergistic or additive effects among various pollutants in water. Biological monitoring has proven to be particularly effective in assessing the environmental risks posed by pollutants in aquatic ecosystems. To date, numerous aquatic organisms, including algae, macrophytes, zooplankton, insects, bivalve mollusks, gastropods, fish, amphibians, and other aquatic species, have demonstrated utility in evaluating these risks. The use of living sentinel organisms enables the integration of diverse bioavailable pollutants present in the environment with assessments of their toxicity, providing an early warning for the health of ecosystems and the human population.

Dr. Hong-Jie Sun
Guest Editor

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Keywords

  • aquatic organism
  • toxicology
  • environmental assessment
  • health risks

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Published Papers (1 paper)

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Research

14 pages, 3956 KiB  
Article
Transcriptomic Analysis of Endocrine System Responses in Zebrafish Embryos Following Exposure to Environmentally Relevant Concentrations of Arsenate
by Tao Li, Di Zhang, Liang Ding, Hongyan Zhou, Yizhong Hou, Huachang Hong, Hongjie Sun and Xinwei Yu
Fishes 2025, 10(3), 97; https://doi.org/10.3390/fishes10030097 - 25 Feb 2025
Viewed by 444
Abstract
Water environments contaminated with arsenic (As) have become a significant environmental concern. Previous research has highlighted the detrimental effects of As on fish, but limited knowledge exists regarding its impacts on endocrine systems. To address this gap, zebrafish embryos were exposed to various [...] Read more.
Water environments contaminated with arsenic (As) have become a significant environmental concern. Previous research has highlighted the detrimental effects of As on fish, but limited knowledge exists regarding its impacts on endocrine systems. To address this gap, zebrafish embryos were exposed to various concentrations (0, 25, 50, 75, and 150 μg/L) of arsenate (AsV) for 120 h post-fertilization (hpf). Our findings indicate that exposure to AsV significantly increases cortisol- and thyroid-stimulating hormone (TSH) levels while decreasing estradiol (E2) and testosterone (T) levels. Additionally, it initially decreases and then increases thyroxine (T4) contents. Furthermore, several key genes relevant to these endocrine systems also show significant influences. The results from principal component analysis demonstrate that TRH, TSH, TRHRb, and TRβ primarily affect the level of T4 while Cyp11b, StAR, hmgrb MC2R, and GR mainly influence cortisol levels. On the other hand, Cyp19a, Cyp17, 17βhsd, ERβ, LHR, hmgrb, and AR predominantly impact E2 and T levels. Transcriptomics and enrichment analysis reveal that these pathways are primarily associated with steroid hormone synthesis and transport. Furthermore, it was found that AsV stimulates the cAMP signaling pathway through a compensation mechanism. These results suggest that AsV may potentially act as environmental endocrine-disrupting chemicals with non-negligible interference effects on the endocrine system in zebrafish. This study holds theoretical value in assessing the environmental risk posed by As overall as well as providing an important basis for addressing human health issues and implementing preventive measures. Full article
(This article belongs to the Special Issue Aquatic Organisms in Toxicology and Environmental Health)
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