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Metabolomics in Marine Invertebrate Aquaculture

A special issue of Fishes (ISSN 2410-3888). This special issue belongs to the section "Genetics and Biotechnology".

Deadline for manuscript submissions: 10 July 2026 | Viewed by 372

Special Issue Editors


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Guest Editor
Shellfish Nutrition and Immunity Group, School of Marine Sciences, Ningbo University, Ningbo 315211, China
Interests: fatty acids; polyunsaturated fatty acids; lipids; lipid droplet; nutrition; microalgae; bivalve; marine mollusks
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Aquaculture Engineering Group, School of Marine Sciences, Ningbo University, Ningbo 315211, China
Interests: light; light spectrum; opsin; photosensitivity; microorganism; development; bivalve; marine invertebrate

Special Issue Information

Dear Colleagues,

The sustainable development of marine invertebrate aquaculture is crucial for meeting the growing global demand for seafood while minimizing environmental impacts. Metabolomics, as a powerful omics approach, provides critical insights into the physiological, nutritional, and stress-related metabolic responses of marine invertebrates, thereby facilitating the optimization of aquaculture practices. This Special Issue focuses on advancing the understanding of metabolomics in marine invertebrate aquaculture, with an emphasis on metabolic pathways, nutrient utilization, stress adaptation, and biomarker discovery. We invite original research articles, comprehensive reviews, and perspective papers that explore key topics, including but not limited to: metabolic profiling of cultured marine invertebrates (e.g., mollusks, crustaceans, and echinoderms), the effects of dietary and environmental stressors on metabolic regulation, functional feed development based on metabolomic data, and the integration of metabolomics with other omics technologies to enhance aquaculture sustainability. Contributions should advance precision nutrition, health management, and biotechnological innovations in marine invertebrate farming.

Dr. Zhaoshou Ran
Guest Editor

Dr. Fei Kong
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fishes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • marine invertebrates
  • aquaculture
  • physiological response
  • stress adaptation
  • nutritional metabolism
  • biomarker discovery
  • omics integration

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Published Papers (1 paper)

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Research

13 pages, 5095 KB  
Article
Genome-Wide Identification and Functional Differentiation of the FTH1 Gene Family: Insights into Immune Response to Vibrio in the Blood Clam Anadara granosa
by Luxia Zhang, Siyi Huang, Yingbin Xu, Sufang Wang and Yongbo Bao
Fishes 2025, 10(12), 646; https://doi.org/10.3390/fishes10120646 - 15 Dec 2025
Viewed by 228
Abstract
Ferritin heavy chain (FTH1) is a key subunit of ferritin and serves as a core regulator of iron metabolism, playing an important role in alleviating cellular damage caused by oxidative stress or regulating programmed cell death. This study identified 7 FTH1 homologs ( [...] Read more.
Ferritin heavy chain (FTH1) is a key subunit of ferritin and serves as a core regulator of iron metabolism, playing an important role in alleviating cellular damage caused by oxidative stress or regulating programmed cell death. This study identified 7 FTH1 homologs (AgFTH1-1 to AgFTH1-7) across the entire genome of Anadara granosa and investigated their expression responses during Vibrio infection. The 7 AgFTH1 genes are arranged in tandem across 6 chromosomes, with AgFTH1-5 and AgFTH1-6 undergoing gene amplification via a local duplication event. Among these homologous genes, 5 genes contain a single conserved ferritin domain (PF00210) and retain key ferroxidase center residues (Glu23, His65). Following Vibrio infection, these 5 genes exhibit downregulated expression, which may increase intracellular free iron and be consistent with ferroptosis-like cell death contributing to pathogen clearance, as suggested by previous studies. AgFTH1-5 contains a signal peptide and exhibits increased expression, suggesting it may regulate extracellular local iron storage. AgFTH1-4 (synaptonemal N-terminal SNARE) and AgFTH1-7 (GTPase domain) lack signal peptides, exhibit atypical structures, and show no significant expression changes under bacterial stress, indicating they may be associated with vesicle trafficking rather than classical iron storage. This study systematically analyzed the genomic features and expression patterns of the FTH1 gene family in A. granosa, laying a foundation for further revealing its role in shellfish immune defense. Full article
(This article belongs to the Special Issue Metabolomics in Marine Invertebrate Aquaculture)
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