Special Issue "Epigenome, Epitranscriptome and Single Cell Analysis in Cell Fate Choice"

A special issue of Epigenomes (ISSN 2075-4655).

Deadline for manuscript submissions: 31 July 2019

Special Issue Editors

Guest Editor
Dr. Luciano Di Croce

Centre for Genomic Regulation (CRG) C/ Dr. Aiguader, 88 PRBB Building 08003 Barcelona
Website | E-Mail
Interests: cancer epigenetics, Polycomb, chromatin remodeling, gene silencing, cellular differentiation, RNA modifications
Guest Editor
Dr. Maria R. Matarazzo

Institute of Genetics and Biophysics ‘Adriano Buzzati-Traverso’, CNR, Naples 80131, Italy
Website | E-Mail
Interests: epigenetics; regulation of gene expression; chromatin; methylation; epigenomics; chromatin structure
Guest Editor
Dr. Annalisa Fico

Institute of Genetics and Biophysics “A. Buzzati-Traverso”, CNR, Naples, Italy
Website | E-Mail
Interests: stem cells; pluripotency/differentiation; neuroscience; neurodegenerative disease; cell metabolism; cell signaling; non-coding RNA

Special Issue Information

Dear Colleagues,

The epigenome refers to the complete DNA methylation, histone modification, nucleosome occupancy, as well as coding and non-coding RNA expression in different cell types. These modifications can result in changes to the structure of chromatin and changes to the function of the genome.The importance of analyzing these modifications at the single cell level is rapidly emerging as a revolutionary reserch area. Similarly, understanding the function and mechanisms of the dynamic RNA modifications, which are termed “RNA epigenetics”, represents a new challenge at the frontier between different disciplines, such as biochemistry, epigenetics, and cutting-edge technology. Reversible RNA modifications add a new dimension to the developing picture of post-transcriptional regulation of gene expression. This new dimension awaits integration with transcriptional regulation (i.e., DNA modifications), to decipher the multi-layered information that controls a plethora of biological functions. The epitranscriptome includes all the biochemical modifications of the RNA (the transcriptome) within a cell. Thus, in the era of advanced technologies, the exciting next step is to move from mapping nucleotide modifications to understanding how they contribute to biological processes.

In this Special Issue, we will consider reviews, research, or method manuscripts of exceptional interest on the following topics:

-Dynamic DNA and RNA modifications;

-Decoding the function of DNA and RNA modifications;

-DNA and RNA epigenetics in cell and development;

-Epigenomes and epitranscriptomes;

-Single cell analysis

Dr. Luciano Di Croce
Dr. Maria R. Matarazzo
Dr. Annalisa Fico
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) is waived for well-prepared manuscripts submitted to this issue. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA methylation
  • RNA modification
  • histone modification
  • N6-methyladenosine (m6A) 
  • epitranscriptome 
  • transcriptome 
  • epigenetics

Published Papers

This special issue is now open for submission.
Epigenomes EISSN 2075-4655 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top