Polycomb Proteins

Dear Colleagues,

Polycomb (PcG) and trithorax (TrxG) groups of proteins are highly conserved multiprotein complexes involved in many biological functions, such as embryonic development, cell proliferation, cell identity, and cell-fate choices. Mechanistically, these chromatin-modifying complexes act antagonistically with respect to gene regulation. The deregulation of proteins belonging to PcG or TrxG families, or alterations in the subunit composition of these complexes, leads to a wide spectrum of developmental disorders and diseases, including cancer.

This Special Issue is focused on the function of PcG and TrxG complexes, both in development and disease. We will consider reviews, research articles, or methods manuscripts of exceptional interest on the following topics:

• Role of PcG or TrxG proteins in cell identity and cell-fate choices;
• Role of PcG or TrxG proteins in development and disease;
• Role of PcG or TrxG in gene expression and three-dimensional organization of the genome.

Prof. Dr. Luciano Di Croce
Prof. Dr. Lluis Morey
Guest Editors

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