Lab-on-Chip Biosensors

A special issue of Electronics (ISSN 2079-9292). This special issue belongs to the section "Bioelectronics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 252

Special Issue Editors


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Guest Editor
Electrical and Computer Engineering, University of California, Santa Cruz, CA 95064, USA
Interests: biomolecule sensing; microfluidic lab-on-a-chip devices; solid-state nanopore sensors

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Guest Editor
Mechanical Engineering, University of Akron, Akron, OH 44325, USA
Interests: micro and nano sensors; biosensors and bioinstrument; lab-on-a-chip; microfluidic and nanofluidic devices; machine health monitoring; artificial neural network for sensor network

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Guest Editor
Electrical and Computer Engineering, University of Alabama, Tuscaloosa, AL 35487, USA
Interests: biomolecule sensing; microfluidic lab-on-a-chip devices; non-linear optics

Special Issue Information

Dear Colleagues,

Lab-on-a-Chip (LoC) biosensors have revolutionized biomedical diagnostics by integrating microfluidics, nanotechnology, and biosensing techniques into miniaturized platforms. These devices enable rapid, sensitive, and cost-effective detection of biomolecules, offering significant advantages in clinical diagnostics, environmental monitoring, and point-of-care testing. With the growing demand for decentralized healthcare and real-time disease monitoring, LoC biosensors play a crucial role in advancing personalized medicine, infectious disease detection, and biomedical research. Recent advancements in materials science, fabrication techniques, and artificial intelligence (AI) integration have further enhanced the capabilities of LoC biosensors. Their ability to process small sample volumes, achieve high-throughput analysis, and deliver rapid results makes them an indispensable tool for modern healthcare and biotechnology. This Special Issue will explore the latest innovations in LoC biosensor technology, addressing key challenges and future directions.

The primary goal of this Special Issue is to highlight cutting-edge developments in lab-on-a-chip biosensors, showcasing novel designs, fabrication methods, and applications. By bringing together interdisciplinary research, this Special Issue will provide a comprehensive overview of state-of-the-art biosensing technologies and their impact on various fields. Given the journal's focus on miniaturized systems, microfluidics, and biosensor applications, this Special Issue aligns well with its scope. The collection of articles will feature fundamental research, experimental studies, and real-world applications, bridging the gap between scientific discovery and practical implementation.

To provide a structured exploration of lab-on-a-chip biosensors, we invite contributions under the following themes:

  • Novel Biosensor Designs and Fabrication Techniques
    • Microfluidic-based biosensors for rapid diagnostics;
    • Nanomaterial-enhanced biosensing platforms;
    • Three-dimensional-printed and flexible LoC biosensors.
  • Applications in Biomedical and Clinical Diagnostics
    • Point-of-care testing for infectious diseases (e.g., COVID-19, influenza, etc.);
    • Cancer biomarker detection and personalized medicine;
    • Organ-on-a-chip models for drug screening.
  • Integration of AI and Machine Learning in LoC Biosensors
    • Data-driven biosensing approaches;
    • Automation and real-time decision-making in diagnostics.
  • Wearable and Implantable LoC Biosensors
    • Continuous health monitoring devices;
    • Wireless and smartphone-based biosensors.

Dr. Ruiting Xu
Prof. Dr. Jiang Zhe
Dr. Leixin Ouyang
Guest Editors

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Keywords

  • lab-on-a-chip (LoC)
  • portable biosensing
  • microfluidic biosensors
  • point-of-care (PoC) diagnostics
  • biomolecular detection

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Published Papers (2 papers)

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Research

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15 pages, 2685 KiB  
Article
High-Speed 1024-Pixel CMOS Electrochemical Imaging Sensor with 40,000 Frames per Second for Dopamine and Hydrogen Peroxide Imaging
by Kevin A. White, Matthew A. Crocker and Brian N. Kim
Electronics 2025, 14(16), 3207; https://doi.org/10.3390/electronics14163207 (registering DOI) - 13 Aug 2025
Abstract
Electrochemical sensing arrays enable the spatial study of dopamine levels throughout brain slices, the diffusion of electroactive molecules, as well as neurotransmitter secretion from single cells. The integration of complementary metal-oxide semiconductor (CMOS) devices in the development of electrochemical sensing devices enables large-scale [...] Read more.
Electrochemical sensing arrays enable the spatial study of dopamine levels throughout brain slices, the diffusion of electroactive molecules, as well as neurotransmitter secretion from single cells. The integration of complementary metal-oxide semiconductor (CMOS) devices in the development of electrochemical sensing devices enables large-scale parallel recordings, providing beneficial high-throughput for drug screening studies, brain–machine interfaces, and single-cell electrophysiology. In this paper, an electrochemical sensor capable of recording at 40,000 frames per second using a CMOS sensor array with 1024 electrochemical detectors and a custom field-programmable gate array data acquisition system is detailed. A total of 1024 on-chip electrodes are monolithically integrated onto the designed CMOS chip through post-CMOS fabrication. Each electrode is paired with a dedicated transimpedance amplifier, providing 1024 parallel electrochemical sensors for high-throughput studies. To support the level of data generated by the electrochemical device, a powerful data acquisition system is designed to operate the sensor array as well as digitize and transmit the output of the CMOS chip. Using the presented electrochemical sensing system, both dopamine and hydrogen peroxide diffusions across the sensor array are successfully recorded at 40,000 frames per second across the 32 × 32 electrochemical detector array. Full article
(This article belongs to the Special Issue Lab-on-Chip Biosensors)
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Review

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43 pages, 3473 KiB  
Review
Biochips on the Move: Emerging Trends in Wearable and Implantable Lab-on-Chip Health Monitors
by Nikolay L. Kazanskiy, Pavel A. Khorin and Svetlana N. Khonina
Electronics 2025, 14(16), 3224; https://doi.org/10.3390/electronics14163224 (registering DOI) - 14 Aug 2025
Abstract
Wearable and implantable Lab-on-Chip (LoC) biosensors are revolutionizing healthcare by enabling continuous, real-time monitoring of physiological and biochemical parameters in non-clinical settings. These miniaturized platforms integrate sample handling, signal transduction, and data processing on a single chip, facilitating early disease detection, personalized treatment, [...] Read more.
Wearable and implantable Lab-on-Chip (LoC) biosensors are revolutionizing healthcare by enabling continuous, real-time monitoring of physiological and biochemical parameters in non-clinical settings. These miniaturized platforms integrate sample handling, signal transduction, and data processing on a single chip, facilitating early disease detection, personalized treatment, and preventive care. This review comprehensively explores recent advancements in LoC biosensing technologies, emphasizing their application in skin-mounted patches, smart textiles, and implantable devices. Key innovations in biocompatible materials, nanostructured transducers, and flexible substrates have enabled seamless integration with the human body, while fabrication techniques such as soft lithography, 3D printing, and MEMS have accelerated development. The incorporation of nanomaterials significantly enhances sensitivity and specificity, supporting multiplexed and multi-modal sensing. We examine critical application domains, including glucose monitoring, cardiovascular diagnostics, and neurophysiological assessment. Design considerations related to biocompatibility, power management, data connectivity, and long-term stability are also discussed. Despite promising outcomes, challenges such as biofouling, signal drift, regulatory hurdles, and public acceptance remain. Future directions focus on autonomous systems powered by AI, hybrid wearable–implantable platforms, and wireless energy harvesting. This review highlights the transformative potential of LoC biosensors in shaping the future of smart, patient-centered healthcare through continuous, minimally invasive monitoring. Full article
(This article belongs to the Special Issue Lab-on-Chip Biosensors)
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