New Insights into the Diagnosis of Pediatric Cholestasis
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 1778
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hyperbilirubinemia occurs in approximately 50% of neonates as an expression of physiological jaundice in the vast majority of cases. Prolonged jaundice (defined as jaundice lasting more than 2 weeks), termed neonatal/infantile cholestasis (NIC), occurs in up to 15% of all neonates and should raise suspicion of cholestasis, prompting further investigation. Rapid etiological definition is of primary importance to initiate appropriate surgical or medical treatment. The broad spectrum of potential causes of NIC requires a complex diagnostic approach that depends on the comprehensive clinical picture. For practical purposes, the causes of cholestasis are divided into surgical (extrahepatic cholestasis) and medical (intrahepatic cholestasis) conditions. The most common surgical cause of NIC is biliary atresia, while medical causes include defects in bile canalicular transport and bile development, inborn errors of bile acid synthesis, and inherited metabolic conditions.
The aim of this Special Issue, titled “New Insights into the Diagnosis of Pediatric Cholestasis”, is to support pediatricians working in primary and secondary care in the initial management of neonatal cholestasis (NIC), alongside pediatric neonatologists and hepatologists working in tertiary referral centers for further diagnostic work-up. We have decided to organize this issue into four sections: the clinical aspect, the surgical approach, diagnostic imaging, and the histological–molecular characteristics of NIC.
Dr. Paola Francalanci
Guest Editor
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Keywords
- extrahepatic cholestasis
- intrahepatic cholestasis
- biliary atresia
- genetic liver disease
- inborn errors of metabolism
- jaundice
- monogenic liver disease
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