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Diagnostics
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Frontier Exploration of Multimodal Imaging in Cardiac Rheumatic and Immune...
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Frontier Exploration of Multimodal Imaging in Cardiac Rheumatic and Immune Diseases

A special issue of Diagnostics (ISSN 2075-4418).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 913

Special Issue Editor

Prof. Dr. Sophie Mavrogeni

E-Mail Website
Guest Editor
Department of Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece
Interests: clinical cardiology; autoimmune diseases; cardiovascular magnetic resonance imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Currently, there has been great progress in the field of both Rheumatology and Immunology that has improved symptoms and survival of patients suffering from these diseases. However, these patients still die earlier than the rest of the population, and cardiovascular disease remains a major cause of death.

Cardiovascular Imaging plays a leading role in both the diagnosis and treatment follow-up of cardiovascular involvement in these patients. Therefore, the “in-depth” knowledge of the contribution of each imaging modality is of paramount importance for the prevention, diagnosis, and follow-up of these patients.

In this context and taking into consideration that diminishing the cardiovascular mortality is the "Holy Grail" of our efforts, we invite you to submit your research, review, and cases in this issue of “Diagnostics”, dedicated to Cardiovascular Imaging in Rheumatology–Immunology. We strongly believe that your contribution will change the ominous prognosis of Cardiovascular disease in Rheumatology–Immunology.

We are looking forward to receiving your manuscripts.

Prof. Dr. Sophie Mavrogeni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • myopericarditis
  • valvular heart disease
  • coronary artery disease
  • vasculitis vascular stenosis
  • vascular aneurysm
  • reynard phenomenon

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Published Papers (1 paper)

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Review

26 pages, 2942 KB  
Review
Multimodal Cardiac Imaging in Systemic Lupus Erythematosus: From Clinical Suspicion to Diagnosis in Clinical Practice
by Mariagrazia Piscione, Barbara Pala, Francesco Cribari, Serena De Mitri, Giada La Placa, Dario Gaudio, Paola Gualtieri and Laura Di Renzo
Diagnostics 2026, 16(7), 988; https://doi.org/10.3390/diagnostics16070988 - 25 Mar 2026
Viewed by 610
Abstract
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation and systemic inflammation, with the cardiovascular (CV) system representing a major yet frequently under-recognized target. Cardiac involvement spans from subclinical myocardial inflammation to overt pericardial disease, myocarditis, valvular abnormalities, [...] Read more.
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation and systemic inflammation, with the cardiovascular (CV) system representing a major yet frequently under-recognized target. Cardiac involvement spans from subclinical myocardial inflammation to overt pericardial disease, myocarditis, valvular abnormalities, coronary microvascular dysfunction, and accelerated atherosclerosis. Given that CV disease remains a leading cause of morbidity and mortality in SLE, early detection of silent cardiac injury is crucial. Aim: This review aims to provide a comprehensive and clinically oriented overview of CV involvement in SLE, focusing on the role of multimodal cardiac imaging in the detection, characterization, and risk stratification of cardiac abnormalities, as well as its potential implications for clinical management and preventive strategies. Methods: This narrative review is based on a structured, non-systematic search of PubMed (2013–2026), combining the term “systemic lupus erythematosus” with imaging-related keywords including “transthoracic echocardiography,” “cardiac magnetic resonance,” and “cardiac computed tomography.” English-language studies in adult populations were screened and selected according to clinical relevance, methodological robustness, and contribution to understanding SLE-related cardiac involvement. Discussion: Multimodal cardiac imaging plays a central role in the evaluation of SLE-related cardiac disease. Transthoracic echocardiography (TTE) represents the first-line modality for the assessment of ventricular function, pericardial disease, and valvular abnormalities, while deformation imaging enables the detection of subtle myocardial dysfunction. Cardiac magnetic resonance (CMR) provides comprehensive tissue characterization, allowing differentiation between active inflammation and chronic fibrosis. Cardiac computed tomography (cCT) identifies subclinical coronary atherosclerosis and high-risk plaque features, whereas nuclear imaging techniques offer insight into inflammatory activity and microvascular dysfunction. Conclusions: An integrated, imaging-based approach enables early diagnosis, refined CV risk stratification, longitudinal monitoring, and personalized therapeutic strategies. Multimodal imaging thus represents a key pillar of precision medicine in lupus-associated CV disease. Full article
(This article belongs to the Special Issue Frontier Exploration of Multimodal Imaging in Cardiac Rheumatic and Immune Diseases)
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