Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
3.0
Journals
Diagnostics
Special Issues
Advances of Spectral Sensors in Detecting and Monitoring Diseases
share announcement

Advances of Spectral Sensors in Detecting and Monitoring Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Point-of-Care Diagnostics and Devices".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 10616

Special Issue Editor

Dr. Cristiana Eugenia Ana Grigorescu

E-Mail Website
Guest Editor
Optospintronics Department, National Institute for Research and Development in Optoelectronics-INOE 2000, 409 Atomistilor, 077125 Magurele, Romania
Interests: spectral sensors; detection of disease; monitoring of treatment; real time assessment; guidance in surgery; laparoscopic surgery; reconstructive surgery; comparative diagnosis in animal and human patients; theranostics; nanostructured and nanoparticle-based sensors; light based sensors; ultrasound; sensors for food-borne diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The current status of diagnostics and monitoring of diseases tends to faster, minimally invasive, and more accurate techniques, including real-time exploration in surgery and bed care monitoring. Food-borne and environment issued diseases should not be neglected. Spectral sensors build a great step in advancing knowledge and technology for enhancing wellness and personalised health-care in human and animal patients. Infrared, UV, Raman spectroscopy, to name only a few and most commonly employed effects, in combinations with nanostructures and nanoparticles, are intensely investigated and prepared to shortage the translation into clinics. Theranostics is already on its way mostly on X-ray, but light and sound can provide equally valuable results. Guidance in laparoscopic, and reconstruction surgery, is of utmost interest, as well as monitoring of stress through cortisol production.

This Special Issue addresses the topics described above, but related research is also welcome.

Dr. C. E.A. Grigorescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spectral sensors
  • detection of disease
  • monitoring of treatment
  • real time assessment
  • guidance in surgery
  • laparoscopic surgery
  • reconstructive surgery
  • comparative diagnosis in animal and human patients
  • theranostics
  • nanostructured and nanoparticle based sensors
  • light based sensors
  • ultrasound

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

14 pages, 10346 KiB  
Article
Identification of Uric Acid Crystals Accumulation in Human and Animal Tissues Using Combined Morphological and Raman Spectroscopy Analysis
by Teodoru Soare, Ana Maria Iordache, George Nicolae, Stefan-Marian Iordache, Cosmin Baciu, Silviu Marinescu, Raluca Ioana Rizac and Manuella Militaru
Diagnostics 2022, 12(11), 2762; https://doi.org/10.3390/diagnostics12112762 - 11 Nov 2022
Cited by 1 | Viewed by 3829
Abstract
Gout is a metabolic condition, common to animals and humans, issuing from the excessive accumulation of end products of proteins degradation. In this study, histopathological and cytological examinations, combined with Raman spectroscopy, have been performed to investigate tissue samples from reptiles, chickens, and [...] Read more.
Gout is a metabolic condition, common to animals and humans, issuing from the excessive accumulation of end products of proteins degradation. In this study, histopathological and cytological examinations, combined with Raman spectroscopy, have been performed to investigate tissue samples from reptiles, chickens, and humans, presenting lesions produced by uric acid accumulation. As a result of classic processing and staining techniques commonly used in the anatomopathological diagnosis, uric acid crystals lose their structural characteristics, thus making difficult a precise diagnostic. Therefore, complementary diagnostic methods, such as Raman spectroscopy, are needed. This study compares from several perspectives the above mentioned diagnostic methods, concluding that Raman spectroscopy provides highlights in the diagnosis of gout in humans and animals, also adding useful information to differential diagnosis of lesions. Full article
(This article belongs to the Special Issue Advances of Spectral Sensors in Detecting and Monitoring Diseases)
►▼ Show Figures

Figure 1

12 pages, 3048 KiB  
Article
Graphene-Based Sensor for the Detection of Cortisol for Stress Level Monitoring and Diagnostics
by Alexei Zubarev, Marina Cuzminschi, Ana-Maria Iordache, Stefan-Marian Iordache, Constantin Rizea, Cristiana E. A. Grigorescu and Carmen Giuglea
Diagnostics 2022, 12(11), 2593; https://doi.org/10.3390/diagnostics12112593 - 26 Oct 2022
Cited by 10 | Viewed by 2300
Abstract
In this work, we study the sensing properties of multi-layer graphene combined with pyrrole in order to elaborate low-cost, high-sensitive material for cortisol detection. Graphene nanoplatelets and pyrrole were dispersed in a solution containing 1M HNO3 by using a powerful ultrasound probe [...] Read more.
In this work, we study the sensing properties of multi-layer graphene combined with pyrrole in order to elaborate low-cost, high-sensitive material for cortisol detection. Graphene nanoplatelets and pyrrole were dispersed in a solution containing 1M HNO3 by using a powerful ultrasound probe for 10 min, then centrifuged for 30 min at 4000 rpm; polymerization was performed by cyclic voltammetry. The graphene–pyrrole composite was tested to ultra-low levels of cortisol in artificial saliva, consistent to the levels excreted in human salivary samples. The composite was further investigated by Raman spectroscopy and we modeled the interaction between the sensitive layer and cortisol using MarvinBeans software. It shows a good sensitivity for salivary values of cortisol cyclic voltammetry being able to detect a level down to 0.5 ng/mL cortisol. Full article
(This article belongs to the Special Issue Advances of Spectral Sensors in Detecting and Monitoring Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

13 pages, 656 KiB  
Review
Current Innovative Methods of Fetal pH Monitoring—A Brief Review
by Roxana-Elena Bohiltea, Bianca Margareta Mihai, Ioniță Ducu, Ana-Maria Cioca, Alexia-Teodora Bohiltea, Ana-Maria Iordache, Stefan-Marian Iordache, Cristiana Eugenia Ana Grigorescu and Silviu Marinescu
Diagnostics 2022, 12(11), 2675; https://doi.org/10.3390/diagnostics12112675 - 3 Nov 2022
Viewed by 2304
Abstract
In this study, we explore the “why?”, and “how?”, monitoring the pH of the fetal scalp is used, and show its limitations. In addition, we review the development of new devices based on the modern physics and nanomaterials serving this topic. Most of [...] Read more.
In this study, we explore the “why?”, and “how?”, monitoring the pH of the fetal scalp is used, and show its limitations. In addition, we review the development of new devices based on the modern physics and nanomaterials serving this topic. Most of the works we found in our search have focused on improving the prognostic of fetal heart rate monitoring, because it is the “golden standard” in determining fetal distress. Although the best-known screening method, it can only provide limited information about the actual status of the fetus. The best predictive assessment, with the highest reproducibility, states that a normal fetal heart rate is indicative of a healthy baby. However, its excellent sensitivity is much reduced when identifying the actual “distress”. This is when second-line monitoring methods come into play to guide the diagnostics and direct the obstetrician towards an action plan. Although a historic method, fetal scalp pH sampling is still under review as to its efficiency and place in the current obstetrics. Continuous surveillance of the fetal parameters is important, especially for the fetuses undergoing intrauterine growth restricted (IUGR). Since fetal scalp blood sampling is still under research and is a randomized controlled trial, which compares the relevance of pH and lactates to the obstetrical situation, the maternal-fetal medicine could greatly benefit from the introduction of engineered nanomedicines to the field. Full article
(This article belongs to the Special Issue Advances of Spectral Sensors in Detecting and Monitoring Diseases)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

9 pages, 2177 KiB  
Case Report
Energy, Waves, and Forces in Bilateral Fracture of the Femoral Necks: Two Case Presentations and Updated Critical Review
by Cosmin Constantin Baciu
Diagnostics 2022, 12(11), 2592; https://doi.org/10.3390/diagnostics12112592 - 26 Oct 2022
Viewed by 1639
Abstract
Two case reports and an updated critical review on bilateral fractures of the femoral neck are presented. Bilateral fractures of the femoral neck have been investigated for at least 80 years and are treated as rare cases. The primary cause is usually considered [...] Read more.
Two case reports and an updated critical review on bilateral fractures of the femoral neck are presented. Bilateral fractures of the femoral neck have been investigated for at least 80 years and are treated as rare cases. The primary cause is usually considered an external shock; however, aside from high energy shocks (e.g., falling and impact with hard, rigid surfaces, traffic accidents, etc.) the underlying causes of femoral neck frailty have not yet been fully understood. Although not exhaustive, the review spans cases reported as early as 1944 and compares their conclusions in line with medicine developments at the time of the reports until present. The discussion is perhaps controversial at times; it brings to the fore the energy balance between shock waves and stress waves. The two cases reported here add to the review, one highlighting the biomechanics, and the other supporting more recent findings on metabolic disorders, which ultimately lead to enhanced frailty of the femoral neck. Investigation of the fractures has been performed with X-ray radiographs, MRI, and CT, with a follow up using a Doppler US to check blood flow in the lower zone of the limbs. The second case was investigated both for fractures and metabolic diseases, e.g., type I diabetes and kidney failure (dialysis). In Case 1 the second fracture was not observable at the time of admission, and therefore two surgery operations were performed at seven days interval. Taperloc Complete prostheses (Zimmer Biomet) were applied. Case 2 suffered a second fracture in the right hip in the segment above the knee and required better fixation with cables. Despite this, she returned one month later with a new crack in the femur. Case 1 is a typical case of wear consequences on the biomechanics of the hill pad-tibia-femur-femoral neck system, where tension of the neck occurred due to a stress wave rather than a shock wave. This can be proven by the absence of a second fracture from the images first acquired, the only evidence being pain and walking difficulty. Case 2 shows that metabolic diseases can dramatically enhance the frequency of bilateral femoral neck fractures. Full article
(This article belongs to the Special Issue Advances of Spectral Sensors in Detecting and Monitoring Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop