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Diagnostics
Special Issues
Novel Diagnostics and Therapeutic Approaches of Retinal Diseases
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Novel Diagnostics and Therapeutic Approaches of Retinal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 4320

Special Issue Editor

Prof. Dr. Mario Damiano Toro

E-Mail Website
Guest Editor
1. Chair and Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20079 Lublin, Poland
2. Faculty of Medical Sciences, Collegium Medicum Cardinal Stefan Wyszyński University, 01815 Warsaw, Poland
Interests: cataract surgery; ocular trauma management; vitreoretinal surgery; experimental ocular surgery and diagnostics; experimental pharmacology; microRNAs and ocular molecular biology

Special Issue Information

Dear Colleagues,

Retinal diseases are the leading causes of vision impairment and blindness. With early detection, most retinal diseases can be treated, while others can be controlled or slowed down to preserve, or even restore vision.

In recent decades, novel diagnostics and therapeutic approaches of retinal diseases have dramatically turned their approach upside down, providing a way for an earlier diagnosis and safer and more effective treatment.

The aim of this Special Issue is to provide an overview of new diagnostics tools and therapeutic approaches in different retinal diseases together to provide the best evidence for proper perioperative and postoperative assessments useful to optimize the response to therapy.

We strive to create a holistic concept throughout the process of diagnosis and treatment based on an individualized and a standardized view, so that treatment of retinal diseases will hopefully not be a challenge in the future.

Prof. Dr. Mario Damiano Toro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical imaging
  • optical coherence tomography (OCT)
  • intraoperative OCT
  • OCT angiography
  • imaging systems
  • biomedical optics
  • in vivo imaging
  • ex vivo imaging
  • polarization
  • fluorescence imaging
  • fundus autofluorescence imaging
  • ocular pharmacology
  • retinal biomarkers
  • drug delivery systems
  • nanothechnologies
  • gene therapy
  • cell therapy

Published Papers (2 papers)

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Research

10 pages, 2453 KiB  
Article
Visualization of Type-1 Macular Neovascularization Secondary to Pachychoroid Spectrum Diseases: A Comparative Study for Sensitivity and Specificity of Indocyanine Green Angiography and Optical Coherence Tomography Angiography
by Sibel Demirel, Pınar Güran Beğar, Özge Yanık, Figen Batıoğlu and Emin Özmert
Diagnostics 2022, 12(6), 1368; https://doi.org/10.3390/diagnostics12061368 - 02 Jun 2022
Cited by 3 | Viewed by 1422
Abstract
Background: The aim of this study was to compare optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) in detecting type-1 macular neovascularization (MNV) in pachychoroid spectrum diseases. Methods: Patients with pachychoroid characteristics who had undergone ICGA and OCTA imaging at the [...] Read more.
Background: The aim of this study was to compare optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) in detecting type-1 macular neovascularization (MNV) in pachychoroid spectrum diseases. Methods: Patients with pachychoroid characteristics who had undergone ICGA and OCTA imaging at the same visit, were recruited. The diagnosis of MNV was made by a senior retina specialist using multimodal imaging techniques. Afterward, both ICGA and OCTA images were separately reviewed by a masked-independent senior retina specialist with regard to the presence of MNV. The specificity, sensitivity, positive, and negative predictive values of ICGA and OCTA were analyzed. Results: OCTA was able to detect MNV with 97.2% sensitivity, failing to detect MNV only in one eye. The sensitivity of ICGA to detect MNV was 66.76%. The negative predictive value of OCTA was 94.7%; however, this value was 60% for ICGA. Multimodal imaging and OCTA were in almost perfect agreement (kappa coefficient = 0.95). Conclusion: OCTA shows greater sensitivity when detecting type-1 MNV than ICGA in pachychoroid neovasculopathy cases. OCTA is a non-invasive and quick imaging modality that can be preferred to dye angiography in the visualization of type-1 MNV in pachychoroid neovasculopathy. Full article
(This article belongs to the Special Issue Novel Diagnostics and Therapeutic Approaches of Retinal Diseases)
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12 pages, 1170 KiB  
Article
Comparison of RetCam and Smartphone-Based Photography for Retinopathy of Prematurity Screening
by Jui-Yen Lin, Eugene Yu-Chuan Kang, Alay S. Banker, Kuan-Jen Chen, Yih-Shiou Hwang, Chi-Chun Lai, Jhen-Ling Huang and Wei-Chi Wu
Diagnostics 2022, 12(4), 945; https://doi.org/10.3390/diagnostics12040945 - 10 Apr 2022
Cited by 7 | Viewed by 2432
Abstract
This study aimed to compare the clinical performance between a smartphone-based fundus photography device and a contact imaging device for retinopathy of prematurity (ROP) screening. All patients were first examined with binocular indirect ophthalmoscopy (BIO), which served as the reference standard. The patients [...] Read more.
This study aimed to compare the clinical performance between a smartphone-based fundus photography device and a contact imaging device for retinopathy of prematurity (ROP) screening. All patients were first examined with binocular indirect ophthalmoscopy (BIO), which served as the reference standard. The patients were then assessed by two devices. Imaging quality, ability to judge the zone and stage of ROP, agreement with the BIO results, vital signs, and pain scores were compared between these two devices. In total, 142 eyes of 71 infants were included. For the smartphone-based fundus photography, image quality was graded excellent or acceptable in 91.4% of examinations, although it was still significantly inferior to that of the contact imaging device (p < 0.001). The smartphone-based fundus photography images had moderate agreement with the BIO results regarding the presence or absence of plus disease (Cohen’s κ = 0.619), but evaluating the zone (p < 0.001) and stage (p < 0.001) of ROP was difficult. Systemic parameters, except for heart rate, were similar between the two imaging devices (all p > 0.05). In conclusion, although the smartphone-based fundus photography showed moderate agreement for determining the presence or absence of plus disease, it failed to identify the zone and stage of ROP. Full article
(This article belongs to the Special Issue Novel Diagnostics and Therapeutic Approaches of Retinal Diseases)
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