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Diagnostics
Special Issues
Advances in the Diagnostics of Osteoarthritis
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Advances in the Diagnostics of Osteoarthritis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 1825

Special Issue Editor

Dr. Lukas A. Holzer

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, Fiona Stanley Fremantle Hospitals Group, 11 Robin Warren Dr, Murdoch, WA 6150, Australia
Interests: osteoarthritis; clinical scores; X-ray; sonography; MRI; CT; bone density scan (DXA); patient reported outcome measures (PROM); molecular markers; genetic markers; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Osteoarthritis is one of the most common diseases of the musculoskeletal system affecting individual patients and healthcare systems worldwide. The diagnostics of osteoarthritis is mainly based on medical history, clinical examination and conventional radiographs. These diagnostic measures have not changed for decades. Recent advances in medical technology might influence the diagnostics and future treatment of OA. This Special Issue focuses on current and potential future diagnostic methods from clinical examination to computer-based diagnostic algorithms.

Dr. Lukas A. Holzer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • clinical scores
  • X-ray
  • sonography
  • MRI
  • CT
  • bone density scan (DXA)
  • patient-reported outcome measures (PROM)
  • molecular markers
  • genetic markers
  • artificial intelligence

Published Papers (1 paper)

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Research

17 pages, 3448 KiB  
Article
A Cationic Contrast Agent in X-ray Imaging of Articular Cartilage: Pre-Clinical Evaluation of Diffusion and Attenuation Properties
by Simone Fantoni, Ilenia Gabucci, Paolo Cardarelli, Gianfranco Paternò, Angelo Taibi, Virginia Cristofori, Claudio Trapella, Armando Bazzani, Marta Assenza, Alice Zanna Bonacorsi, Daniele Conti and Fabio Baruffaldi
Diagnostics 2022, 12(9), 2111; https://doi.org/10.3390/diagnostics12092111 - 31 Aug 2022
Viewed by 1453
Abstract
The aim of this study was the preliminary assessment of a new cationic contrast agent, the CA4+, via the analysis of spatial distribution in cartilage of ex vivo bovine samples, at micrometer and millimeter scale. Osteochondral plugs (n = 18) extracted from [...] Read more.
The aim of this study was the preliminary assessment of a new cationic contrast agent, the CA4+, via the analysis of spatial distribution in cartilage of ex vivo bovine samples, at micrometer and millimeter scale. Osteochondral plugs (n = 18) extracted from bovine stifle joints (n = 2) were immersed in CA4+ solution up to 26 h. Planar images were acquired at different time points, using a microCT apparatus. The CA4+ distribution in cartilage and saturation time were evaluated. Tibial plates from bovine stifle joints (n = 3) were imaged with CT, before and after 24 h-CA4+ bath immersion, at different concentrations. Afterward, potential CA4+ washout from cartilage was investigated. From microCT acquisitions, the CA4+ distribution differentiated into three distinct layers inside the cartilage, reflecting the spatial distribution of proteoglycans. After 24 h of diffusion, the iodine concentration reached in cartilage was approximately seven times that of the CA4+ bath. The resulting saturation time was 1.9 ± 0.9 h and 2.6 ± 2.9 h for femoral and tibial samples, respectively. Analysis of clinical CT acquisitions confirmed overall contrast enhancement of cartilage after 24 h immersion, observed for each CA4+ concentration. Distinct contrast enhancement was reached in different cartilage regions, depending on tissue’s local features. Incomplete but remarkable washout of cartilage was observed. CA4+ significantly improved cartilage visualization and its qualitative analysis. Full article
(This article belongs to the Special Issue Advances in the Diagnostics of Osteoarthritis)
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