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Diagnostics
Special Issues
Advances in Diagnosis and Management of Endometrial Cancer
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Advances in Diagnosis and Management of Endometrial Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 918

Special Issue Editor

Dr. Fulvio Borella

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Guest Editor
Dipartimento di Scienze Chirurgiche, Università degli Studi di Torino (UNITO), Turin, Italy
Interests: cancer biology; gynecologic oncology; tumor biomarkers; cancer diagnostics; breast cancer; ovarian cancer; endometrial cancer; vulvar cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometrial cancer is the most common gynecological malignancy and the fourth most common cancer in women in developed countries. The incidence and mortality of endometrial cancer are increasing due to the aging population, obesity epidemic, and lack of effective screening methods. Endometrial cancer is a heterogeneous disease with different histological subtypes, molecular alterations, and clinical outcomes. The current diagnosis and management of endometrial cancer are mainly based on histopathological features, surgical staging, and risk stratification. However, these parameters have limitations in predicting the prognosis and response to treatment of individual patients. Therefore, there is an urgent need for novel biomarkers and therapeutic strategies that can improve the accuracy of diagnosis, prognosis, and personalized treatment of endometrial cancer. This special issue aims to provide an update on the recent advances in the understanding of the pathogenesis, molecular classification, and targeted therapy of endometrial cancer. It will cover topics such as the role of genetic and epigenetic factors, hormonal and metabolic pathways, immune and inflammatory responses, and microenvironmental factors in endometrial carcinogenesis and progression; the application of molecular and genomic tools in the diagnosis, prognosis, and prediction of treatment response of endometrial cancer; the development and evaluation of novel targeted agents and immunotherapies for endometrial cancer; and the challenges and opportunities in the clinical management of endometrial cancer. We invite researchers and clinicians to submit original research articles, reviews, and commentaries that will contribute to the advancement of the field of endometrial cancer.

Dr. Fulvio Borella
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer biology
  • gynecologic oncology
  • tumor biomarkers
  • cancer diagnostics
  • breast cancer
  • ovarian cancer
  • endometrial cancer
  • vulvar cancer

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Published Papers (1 paper)

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Research

18 pages, 7766 KB  
Article
Epidemiological and Histopathological Characterization of Endometrial Carcinoma: A Retrospective Cohort from Romania
by Andrei Muraru, Alex-Emilian Stepan, Claudiu Margaritescu, Mirela Marinela Florescu, Anne-Marie Badiu, Iulia Oana Cretu, Bianca Catalina Andreiana and Raluca Niculina Ciurea
Diagnostics 2025, 15(20), 2645; https://doi.org/10.3390/diagnostics15202645 - 20 Oct 2025
Viewed by 214
Abstract
Background/Objectives: Endometrial carcinoma is an emerging challenge for public health systems globally, especially in countries with a high development index. Traditionally, histopathological staging and grading have been the main criteria informing treatment modalities. More recently, clinically actionable molecular targets have been developed, [...] Read more.
Background/Objectives: Endometrial carcinoma is an emerging challenge for public health systems globally, especially in countries with a high development index. Traditionally, histopathological staging and grading have been the main criteria informing treatment modalities. More recently, clinically actionable molecular targets have been developed, following observations from the TCGA project and the ProMisE cohort. Although promising, the cost of these methods is an obstacle for some countries that lack well developed theranostics infrastructure in their public systems. This study aimed to contextualize our center’s diagnostic experience from the perspective of histopathological diagnosis. Methods: This is a retrospective study that selected 109 cases of already diagnosed endometrial carcinoma from the interval of 2017–2023. We analyzed traditional parameters related to staging and grading, using the FIGO 2009 system as well as basic histological parameters (lymphovascular invasion, perineural invasion, necrosis). Excel and SPSS 26 were used for database management and correlations. Findings were contextualized using the more recent studies that reported on similar parameters. Results: Higher-grade tumors were associated with lymphovascular invasion (p = 0.04) and lymph node involvement (p = 0.0006), as well as deeper myoinvasion (p = 0.0018). Myoinvasion (p = 0.013) and lymphovascular invasion (p = 0.0001) were associated with advanced disease (FIGO III and IV). Our cohort showed a relative paucity (6.5%) of non-endometrioid endometrial carcinoma and presence of lymphovascular invasion (9.2%). Perineural invasion was found in 3 cases with extrauterine involvement. Conclusions: Histopathological diagnosis represents an integral component in informing clinical management for endometrial carcinoma and should serve as a means of triage for more expensive molecular techniques. It nevertheless presents reproducibility issues. Further efforts should focus on resolving such issues or possibly introducing less-researched parameters like perineural invasion. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Management of Endometrial Cancer)
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