Pediatric Diseases: From Diagnosis to Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 152

Special Issue Editor


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Guest Editor
1. Clinical Genetics Outpatient Clinic, Mother and Child Health Care Institute of Serbia “Dr. Vukan Cupic”, 11070 Belgrade, Serbia
2. Department of Pediatrics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Interests: pediatric diseases

Special Issue Information

Dear Colleagues,

Advances in pediatric medicine have significantly reshaped the diagnosis and management of diseases in children. Progress in genetics, molecular diagnostics, imaging, and digital technologies has enabled earlier recognition of disease, improved etiological understanding, and the development of targeted and individualized therapeutic approaches. Nevertheless, pediatric practice continues to face major challenges, particularly in the diagnosis and management of rare, complex, and multisystem disorders.

We are pleased to invite submissions to this Special Issue, “Pediatric Diseases: From Diagnosis to Management,” which aims to present current concepts, innovative methodologies, and clinically relevant research across the full spectrum of pediatric diseases. The Special Issue is closely aligned with the journal’s scope and emphasizes translational research that bridges scientific advances and everyday clinical practice.

Original research articles, reviews and relevant case reports are welcome. Topics of interest include, but are not limited to, advances in pediatric diagnostics, management strategies for rare and complex conditions, precision and personalized medicine in pediatrics, translational approaches, and interdisciplinary aspects of pediatric care.

We look forward to receiving your contributions.

Dr. Adrijan Sarajlija
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric diseases
  • diagnosis
  • management
  • translational research
  • rare and complex disorders
  • precision medicine
  • molecular diagnostics
  • interdisciplinary care

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Published Papers (1 paper)

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Research

26 pages, 1100 KB  
Article
Physical Activity Patterns and Cardiometabolic Risk in Children and Adolescents with Obesity: A Cross-Sectional Study
by Lorena Mihaela Manole, Elena Țarcă, Elena-Lia Spoială, Laura Otilia Boca, Mădălina Andreea Donos, Gabriela Păduraru, Gabriela Ghiga, Viorel Țarcă, Alin Constantin Pînzariu and Laura Mihaela Trandafir
Diagnostics 2026, 16(8), 1162; https://doi.org/10.3390/diagnostics16081162 - 14 Apr 2026
Abstract
Introduction: Childhood and adolescent obesity is a growing global health challenge associated with early metabolic and cardiovascular complications. This study aims to compare questionnaire-assessed physical activity patterns and lifestyle characteristics among children and adolescents with obesity and normal-weight peers and to explore [...] Read more.
Introduction: Childhood and adolescent obesity is a growing global health challenge associated with early metabolic and cardiovascular complications. This study aims to compare questionnaire-assessed physical activity patterns and lifestyle characteristics among children and adolescents with obesity and normal-weight peers and to explore their associations with clinical measurements and cardiometabolic risk. Assessing resting metabolic rate (RMR) by indirect calorimetry may provide additional insight into metabolic status beyond conventional anthropometric indicators. Methods: This prospective cross-sectional study included 58 children and adolescents aged 5–18 years with obesity and 30 normal-weight controls evaluated in Sfânta Maria Emergency Children’s Hospital Iași, Romania. Clinical data included anthropometric measurements and available biochemical parameters. RMR was assessed through indirect calorimetry (Fitmate Pro, Cosmed, Rome, Italy). Parents completed a structured lifestyle questionnaire adapted from validated international instruments, collecting information on physical activity, sedentary behavior, and wearable device use. Data analysis was conducted using SPSS 22.0, applying descriptive statistics and Pearson correlation analysis. Results: Children with obesity reported higher body mass index (BMI) (30.48 ± 5.31 kg/m2), higher RMR values, lower physical activity levels and greater sedentary time than controls. RMR correlated positively with BMI, central adiposity, blood pressure, waist-to-height, hepatic steatosis and exercise tolerance. Although electronic devices for monitoring physical activity were more frequently used in the obesity group, this was not associated with higher activity levels. Conclusions: Children and adolescents with obesity exhibited a clustered cardiometabolic risk profile and reduced physical activity. RMR measured by indirect calorimetry may contribute to a more comprehensive metabolic assessment in pediatric obesity. Full article
(This article belongs to the Special Issue Pediatric Diseases: From Diagnosis to Management)
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