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Diagnostics
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Dermatology Essentials
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Dermatology Essentials

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 10630

Special Issue Editors

Prof. Dr. Laura Gheuca-Solovastru

E-Mail Website
Guest Editor
Dermato-venerology Department, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Interests: psoriasis; atopic dermatitis; pemphigus vulgaris; epidermolysis bullosa; fungal infections; acne vulgaris
Dr. Mihai Lupu

E-Mail Website
Guest Editor
Department of Dermatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Interests: non-invasive diagnosis; skin tumors; inflammatory skin diseases; skin infestations
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Healthy skin and good quality of life are becoming increasingly popular goals in modern times, in which psychological stress, irritant agents, exposure to UV radiation and the social pressure to be as aesthetically pleasing as possible influence us more than ever before. Be it ordinary contact dermatitis, atopic dermatitis, psoriasis, pemphigus or melanoma, the need for efficient therapeutic strategies is a priority. Despite the great therapeutic progress in atopic dermatitis and psoriasis, with novel therapies coming out faster than ever, these patients still suffer from a decreased quality of life. The long-term treatment of bullous autoimmune disorders is a challenge, especially in countries where biologics have not yet been approved and side effects and drawbacks of conventional therapies are still under debate.

In this Special Issue, we invite you to contribute to the knowledge of dermatology, dermato-oncology, pediatric dermatology, skin imaging and psychodermatology. We invite authors to share their input on clinical and paraclinical diagnostics, histopathology, treatment and strategies for coping with complications. We welcome original research papers as well as reviews.

Prof. Dr. Laura Gheuca-Solovastru
Dr. Mihai Lupu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin
  • dermatology
  • dermatopathology
  • melanoma skin cancer
  • non-melanoma skin cancer
  • skin tumors
  • optical coherence tomography
  • reflectance confocal microscopy
  • skin ultrasound
  • dermatoscopy
  • inflammoscopy
  • trichoscopy
  • inflammatory skin diseases
  • acne
  • psoriasis
  • pemphigus
  • atopic dermatitis
  • hidradenitis suppurativa
  • eczema
  • trophic ulcers
  • alopecia
  • scar
  • nail disorders
  • skin infestations
  • skin aging

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Published Papers (2 papers)

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Research

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12 pages, 1293 KiB  
Article
Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania
by Ioana Adriana Popescu, Dan Vata, Doinita Temelie Olinici, Bogdan Marian Tarcau, Adriana Ionela Patrascu, Ioana Alina Halip, Dumitrita Lenuta Gugulus, Madalina Mocanu and Laura Gheuca Solovastru
Diagnostics 2024, 14(1), 57; https://doi.org/10.3390/diagnostics14010057 - 26 Dec 2023
Viewed by 2231
Abstract
Background: Autoimmune bullous diseases (ABDs) are a rare but significant group of dermatoses that pose great challenges to the treating dermatologist. ABDs are characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens of the skin. Most epidemiological studies [...] Read more.
Background: Autoimmune bullous diseases (ABDs) are a rare but significant group of dermatoses that pose great challenges to the treating dermatologist. ABDs are characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens of the skin. Most epidemiological studies have focused on a single ABD. More than that, there are few data about the incidence and prevalence of autoimmune blistering diseases in Romania. Methods: In this study, between 2015 and 2019, we retrospectively investigated a total of 225 patients with autoimmune bullous diseases from the northeastern region of Romania. The diagnosis was based on the clinical and histo- and immunohistological findings. Results: Pemphigus was the most frequently encountered ABD, with an incidence of 8.16/1,000,000 inhabitants, representing 58.7% (132 cases), followed by 24% cases of bullous pemphigoid (54 cases), 15.4% of patients were diagnosed with dermatitis herpetiformis (37 cases), and 0.9% other subepidermal autoimmune bullous dermatoses. The average age of onset of pemphigus vulgaris was 59.4 years, the majority of patients being male, while the average age of patients diagnosed with bullous pemphigoid was 73.8 years, the majority being female. Conclusions: Pemphigus vulgaris is the most frequently encountered ABDs in the northeast of Romania, with a higher incidence than in Western European countries, and this may be due to specific peculiarities of the geographical area, as well as to a genetic susceptibility of the population in this region. Full article
(This article belongs to the Special Issue Dermatology Essentials)
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Review

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23 pages, 3416 KiB  
Review
The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases
by Minela Aida Maranduca, Mihai Andrei Cosovanu, Andreea Clim, Alin Constantin Pinzariu, Nina Filip, Ilie Cristian Drochioi, Vlad Ionut Vlasceanu, Daniel Vasile Timofte, Roxana Nemteanu, Alina Plesa, Mihaela Pertea and Ionela Lacramioara Serban
Diagnostics 2023, 13(22), 3398; https://doi.org/10.3390/diagnostics13223398 - 7 Nov 2023
Cited by 4 | Viewed by 7388
Abstract
Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these [...] Read more.
Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these conditions. RAS is a multicomponent cascade, primarily known for its role in regulating blood pressure and fluid balance. All of the RAS components play an important role in controlling inflammation and other immune responses. Angiotensin II, the main effector, acts on two essential receptors: Angiotensin Receptor 1 and 2 (AT1R and AT2R). A disturbance in the axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers diverse signaling cascades involved in inflammation, fibrosis and tissue remodeling. Experimental studies have demonstrated the presence of AT1R in various cutaneous cells and immune cells, further emphasizing its potential contribution to the AI processes in the skin. Furthermore, recent investigations have highlighted the role of other RAS components, beyond angiotensin-converting enzyme (ACE) and Ang II, that may contribute to the pathophysiology of AIDD. Alternative pathways involving ACE2, Ang receptors and Ang-(1-7) have been implicated in regulating immune responses and tissue homeostasis within the skin microenvironment. Understanding the intricate involvement of the RAS in AIDD may provide novel therapeutic opportunities. Targeting specific components of the RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative RAS pathway modulators, could potentially ameliorate inflammatory responses, reduce tissue damage and lessen disease manifestations. Further research is warranted to outline the exact mechanisms underlying RAS-mediated immune dysregulation in AIDD. This abstract aims to provide a concise overview of the intricate interplay between the RAS and AIDD. Therefore, we elaborate a systematic review of the potential challenge of RAS in the AIDD, including psoriasis, systemic sclerosis, vitiligo, lupus erythematosus and many more. Full article
(This article belongs to the Special Issue Dermatology Essentials)
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