Advances in Diagnosis and Management of Pancreatic and Biliary Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 147

Special Issue Editor


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Guest Editor
Department of Gastroenterology, Matsunami General Hospital, Gifu, Japan
Interests: biliary tract diseases; pancreatic diseases; EUS
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Special Issue Information

Dear Colleagues,

In recent years, we have witnessed remarkable progress in the diagnosis of biliary–pancreatic disorders thanks to advances in endoscopic procedures and image diagnosis (e.g., CT, MRI, EUS, ERCP, cholangioscopy, and pancreatoscopy). The diagnosis of early biliary–pancreatic cancer is a pressing issue, and the aforementioned techniques can increase the chances of early biliary–pancreatic cancer detection; however, there are still significant gaps in our knowledge in relation to the follow-up period and key findings. Advances in endoscopic devices including the EUS-FNA needle can improve the accuracy of malignant disease diagnosis and help us to obtain large tissue samples for next-generation sequencing. Tissue sampling under ERCP is not sufficient; however, new devices and methods can improve the diagnostic accuracy of histological and cytological diagnosis. Detecting the spread of malignant disease is also important in determining the appropriate treatment. For benign diseases, differential diagnosis for the biliary and pancreatic duct stricture is important. Moreover, tissue sampling is required in benign diseases, including IgG4-related disease, to inform treatment decisions.

For this Special Issue, we welcome the submission of novel data, methods, devices, and reviews related to this topic.

Dr. Mitsuru Okuno
Guest Editor

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Keywords

  • biliary–pancreatic cancer
  • malignancy
  • benign biliary
  • stricture
  • ERCP
  • EUS
  • EUS-FNA
  • IgG4-related disease

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Published Papers (1 paper)

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Research

11 pages, 795 KiB  
Article
Branch Duct IPMN-Associated Acute Pancreatitis in a Large Single-Center Cohort Study
by Nicolò de Pretis, Luigi Martinelli, Antonio Amodio, Federico Caldart, Salvatore Crucillà, Maria Sole Battan, Alberto Zorzi, Stefano Francesco Crinò, Maria Cristina Conti Bellocchi, Laura Bernardoni, Giulia De Marchi, Pietro Campagnola, Roberto Salvia, Armando Gabbrielli, Alessandro Marcon and Luca Frulloni
Diagnostics 2025, 15(13), 1676; https://doi.org/10.3390/diagnostics15131676 - 1 Jul 2025
Abstract
Background/Objectives: IPMNs are a possible cause of acute pancreatitis (AP). IPMN-associated-AP is considered a relative indication for surgery for the prevention of recurrent attacks of pancreatitis and for a hypothesized increased cancer risk. The literature is based on surgical series, and no [...] Read more.
Background/Objectives: IPMNs are a possible cause of acute pancreatitis (AP). IPMN-associated-AP is considered a relative indication for surgery for the prevention of recurrent attacks of pancreatitis and for a hypothesized increased cancer risk. The literature is based on surgical series, and no data on the clinical features of AP associated with IPMNs and on the risk of recurrent pancreatitis and pancreatic cancer are available. This study aimed to describe the clinical/radiological features of BD-IPMN-associated AP. Moreover, BD-IPMN-associated risk factors for AP recurrence and risk of pancreatic cancer were investigated. Methods: Patients with AP associated with branch-duct IPMN (BD-IPMN) without “worrisome- features” and “high-risk-stigmata” evaluated in a Gastroenterology Unit (University of Verona) between 1 January 2012 and 31 December 2022 were retrospectively analyzed. Cox proportional hazard models were used to analyze the time to recurrence after the first occurrence of AP. Results: One hundred and thirty-five patients were included, with a mean age of 55.8 ± 12.5 years. Necrosis was diagnosed in 15 patients (11.1%) and 1 patient (0.7%) was admitted to the ICU. One hundred and two (75.6%) patients had recurrent pancreatitis. The median size of the largest BD-IPMN was 8 mm (Q1–Q3: 5–12). Eighteen patients (13.3%) developed main pancreatic duct dilation ≥ 5 mm. No patients developed dilation of the main pancreatic duct ≥ 10 mm, mural nodules, thickened cystic walls, or jaundice. In the unadjusted analysis, no BD-IPMN-related features were associated with an increased risk of recurrent pancreatitis. None of the patients developed pancreatic cancer. Conclusions: BD-IPMN-associated AP appears to have a benign clinical course. Cystic features related to increased risk of recurrence were not identified. The risk of cancer appears extremely low. Full article
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