Diagnostics

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Special Issue Editor

Dr. Fabrice Caillol

E-Mail Website
Guest Editor

Institut Paoli-Calmettes, Marseille, France
Interests: gastroenterology; pancreatic diseases; biliary tract diseases; gastrointestinal diseases; endoscopy; liver diseases; hepatocellular carcinoma; liver cirrhosis; esophageal diseases; cirrhosis

Special Issue Information

Dear Colleagues,

Digestive endoscopy is now a specialized technique needing experienced and skilled operators. Diagnosis with endoscopy includes samples with pathological examination and endoscopic visualization of images with white lumen and electronic coloration, sometimes without the need for histology. Sometimes new kinds of histology are used instead of classical pathology (confocal endomicroscopy, Raman technique, etc.). New endoscopic methods of diagnosis are becoming more and more developed and are spreading throughout the endoscopist community. These methods can change patient management and therapeutics. This Special Issue will focus on new methods of diagnosis with potential consequences for the management of patients.

Dr. Fabrice Caillol
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

diagnosis
endoscopy
endoscopic management
new histology
virtual histology
optical histology

Published Papers (2 papers)

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Research

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10 pages, 6607 KiB

Open AccessArticle

Association between Endoscopic Milk-White Mucosa, Epithelial Intracellular Lipid Droplets, and Histological Grade of Superficial Non-Ampullary Duodenal Epithelial Tumors

by Yuko Hara, Kenichi Goda, Shinichi Hirooka, Takehiro Mitsuishi, Masahiro Ikegami and Kazuki Sumiyama

Diagnostics 2021, 11(5), 769; https://doi.org/10.3390/diagnostics11050769 - 25 Apr 2021

Cited by 6 | Viewed by 2596

Abstract

We previously reported that superficial non-ampullary duodenal tumors (SNADETs) commonly had a whitish mucosal surface, named milk-white mucosa (MWM). The aim of this study was to evaluate the association of MWM with epithelial intracellular lipid droplets (immunohistochemically stained by adipose differentiation-related protein (ADRP)) and histological tumor grades. We reviewed endoscopic images and the histopathology of SNADETs resected en bloc endoscopically. We analyzed the correlation between the positive rates of endoscopic MWM in preoperative endoscopy and resected specimens, and ADRP-positive rates in the resected specimens. Associations between the MWM-positive rates and tumor grades, high-grade intraepithelial neoplasia (HGIN)/intramucosal carcinoma (IC), and low-grade intraepithelial neoplasia (LGIN) were analyzed. All the 92 SNADETs analyzed were <20 mm and histologically classified into 39 HGIN/IC and 53 LGIN. Spearman’s rank correlation coefficient showed a significant correlation between MWM-positive and ADRP-positive rates (p < 0.001). MWM-positive rates were significantly lower in the HGIN/IC than in the LGIN in preoperative endoscopy (p < 0.001) and resected specimens (p = 0.02). Our results suggest that endoscopic MWM is closely associated with epithelial intracellular lipid droplets and that the MWM-positive rate may be a predictor of histological grade in small SNADETs. Full article

(This article belongs to the Special Issue Diagnosis and Management of Gastrointestinal Diseases: Using Digestive Endoscopy)

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8 pages, 38903 KiB

Open AccessCase Report

Preoperative Diagnosis Failure for a Rare Gastric Collision Tumor: A Case Report

by Rabie E. Elshaer, Eid R. Elgammal, Amr M. Elmistekawy, Walaa A. Ghannam, Ahmed E. Elshamy, Sally Y. Abed and Sawsan A. Zaitone

Diagnostics 2021, 11(4), 633; https://doi.org/10.3390/diagnostics11040633 - 1 Apr 2021

Cited by 1 | Viewed by 1695

Abstract

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors of the gastrointestinal tract (GIT), usually occur as a solitary neoplasm. Inflammatory florid polyp (IFP) is a solitary rare benign lesion of the gastrointestinal tract, mainly occur in the gastric antrum, whose atypical presentation can mimic GISTs or other malignant tumors, therefore the synchronous occurrence of GISTs and IFP is extremely rare. We had a case of a 58-year-old man that was presented with recurrent epigastric pain and recurrent melena. Upper endoscopic examination revealed a large polypoid antrum polyp measured 7 cm at greatest dimension with focal ulceration. Clinical and radiological features did not reach the definite diagnosis until histopathological evaluation with immunohistochemical analysis was performed. Surgical intervention is recommended and partial gastrectomy was done with wide resection margins. Histological examination revealed two distinct GISTs and IFP parts presenting a collision tumor that showed spindle and epitheloid cells consistent with GISTs with histological features of florid polyp showed a characteristic perivascular onion-skin arrangement of spindle cells with dense chronic inflammatory infiltrate including eosinophils and lymphocytes. Immunohistochemical studies have been done and revealed an association between GISTs and IFP. To the best of our knowledge, this is the first case of a collision tumor consisting of a GIST and an IFP arising in the stomach. In conclusion, the gastrointestinal stromal tumor is the comments mesenchymal tumor of GIT and IFP is a rare benign lesion of GIT therefore association between GIST and IFP as a collision tumor is extremely rare. Full article

(This article belongs to the Special Issue Diagnosis and Management of Gastrointestinal Diseases: Using Digestive Endoscopy)

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