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Diagnostics
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Diagnosis of Ischaemic Heart Disease
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Diagnosis of Ischaemic Heart Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 9784

Special Issue Editors

Prof. Dr. Gary Tse

E-Mail Website
Guest Editor
Cardiac Electrophysiology Unit, Cardiovascular Analytics Group, Hong Kong
Interests: cardiac electrophysiology; predictive risk modelling
Dr. Sharen Lee

E-Mail Website
Guest Editor
Medical Education Unit, Cardiovascular Analytics Group, China-UK Collaboration, Hong Kong
Interests: cardiovascular disease; arrhythmia; diabetes

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit to our Special Issue—“diagnosis of ischemic heart disease”. With an aging population and increasing number of people with sedentary lifestyles, ischemic heart disease has become the leading cause of death globally. Early diagnosis is one of the keys to promoting the survival and quality of life of patients with ischemic heart disease.

This Special Issue aims to encourage the publication of studies on advancements in the diagnosis of ischemic heart disease.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: clinical features, biomarkers, and investigations that facilitate an early and accurate diagnosis of ischemic heart disease. Multidisciplinary work involving machine learning, artificial intelligence, and digital health are particularly welcomed.

We look forward to receiving your contributions.

Prof. Dr. Gary Tse
Dr. Sharen Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ischemic heart disease
  • coronary heart disease
  • atherosclerosis
  • cardiovascular disease
  • metabolic syndrome
  • electrocardiography
  • machine learning
  • diagnosis

Published Papers (4 papers)

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Research

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11 pages, 2976 KiB  
Article
Retinal Microvascular Abnormalities Predict Clinical Outcomes in Patients with Heart Failure
by Shaohua Guo, Songtao Yin, Wenhua Song, Gary Tse, Juping Liu, Kaiwen Hei, Kangyin Chen, Long Su and Tong Liu
Diagnostics 2022, 12(9), 2078; https://doi.org/10.3390/diagnostics12092078 - 27 Aug 2022
Cited by 1 | Viewed by 1525
Abstract
Background: Narrower retinal arterioles and wider retinal venules have been associated with the incidence of heart failure (HF). However, whether they are predictive of the prognosis of heart failure (HF) is unclear. We aimed to explore the role of retinal vessel calibers in [...] Read more.
Background: Narrower retinal arterioles and wider retinal venules have been associated with the incidence of heart failure (HF). However, whether they are predictive of the prognosis of heart failure (HF) is unclear. We aimed to explore the role of retinal vessel calibers in predicting long-term clinical outcomes of HF. Methods: This is a prospective, single-center, observational study that surveyed patients in a tertiary referral hospital for the treatment of HF. Retinal vessel caliber was graded using retinal photography. The primary endpoint was the composite endpoint of HF rehospitalization and mortality at 12 months. Results: There were 55 patients with chronic HF included in the final analysis. At 12 months, the cumulative incidence of the primary endpoint, HF rehospitalization, and mortality tended to be higher with the widening of the central retinal venular equivalent (CRVE) (p for non-linearity = 0.059) and was significantly increased when CRVE reached a cut-off value (283 μm) (p = 0.011) following adjustment for age, sex, etiology of HF, and diabetes. No association between the central retinal arteriolar equivalent (CRAE) and arteriolar-to-venular caliber ratio (AVR) was found with the clinical outcome in both univariable and multivariable Cox regression. CRAE, CRVE, and AVR had no relationship with the concentration of the N-terminal pro-B-type natriuretic peptide. In addition, CRVE was not associated with cardiac diastolic and systolic function. Conclusions: When the retinal venular caliber widens to a certain point, the composite incidence of HF rehospitalization and mortality significantly increase, suggesting retinal vessel caliber imaging may provide insight into the development of HF. Full article
(This article belongs to the Special Issue Diagnosis of Ischaemic Heart Disease)
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Review

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23 pages, 5073 KiB  
Review
Qualitative and Quantitative Stress Perfusion Cardiac Magnetic Resonance in Clinical Practice: A Comprehensive Review
by Wenli Zhou, Jason Sin, Andrew T. Yan, Haonan Wang, Jing Lu, Yuehua Li, Paul Kim, Amit R. Patel and Ming-Yen Ng
Diagnostics 2023, 13(3), 524; https://doi.org/10.3390/diagnostics13030524 - 31 Jan 2023
Cited by 2 | Viewed by 4137
Abstract
Stress cardiovascular magnetic resonance (CMR) imaging is a well-validated non-invasive stress test to diagnose significant coronary artery disease (CAD), with higher diagnostic accuracy than other common functional imaging modalities. One-stop assessment of myocardial ischemia, cardiac function, and myocardial viability qualitatively and quantitatively has [...] Read more.
Stress cardiovascular magnetic resonance (CMR) imaging is a well-validated non-invasive stress test to diagnose significant coronary artery disease (CAD), with higher diagnostic accuracy than other common functional imaging modalities. One-stop assessment of myocardial ischemia, cardiac function, and myocardial viability qualitatively and quantitatively has been proven to be a cost-effective method in clinical practice for CAD evaluation. Beyond diagnosis, stress CMR also provides prognostic information and guides coronary revascularisation. In addition to CAD, there is a large body of literature demonstrating CMR’s diagnostic performance and prognostic value in other common cardiovascular diseases (CVDs), especially coronary microvascular dysfunction (CMD). This review focuses on the clinical applications of stress CMR, including stress CMR scanning methods, practical interpretation of stress CMR images, and clinical utility of stress CMR in a setting of CVDs with possible myocardial ischemia. Full article
(This article belongs to the Special Issue Diagnosis of Ischaemic Heart Disease)
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11 pages, 321 KiB  
Review
Fractional Flow Reserve-Guided Coronary Revascularization: Evidence from Randomized and Non-Randomized Studies
by Luca Paolucci, Fabio Mangiacapra, Michele Mattia Viscusi, Annunziata Nusca, Giuseppe Zimbardo, Pio Cialdella, Michael Edward Donahue, Leonardo Calò, Gian Paolo Ussia and Francesco Grigioni
Diagnostics 2022, 12(11), 2659; https://doi.org/10.3390/diagnostics12112659 - 1 Nov 2022
Cited by 1 | Viewed by 1461
Abstract
Simple visual estimation of coronary angiography is limited by several factors that can hinder the proper classification of coronary lesions. Fractional flow reserve (FFR) is the most widely used tool to perform a physiological evaluation of coronary stenoses. Compared to isolated angiography, FFR [...] Read more.
Simple visual estimation of coronary angiography is limited by several factors that can hinder the proper classification of coronary lesions. Fractional flow reserve (FFR) is the most widely used tool to perform a physiological evaluation of coronary stenoses. Compared to isolated angiography, FFR has been demonstrated to be more effective in selecting those lesions associated with myocardial ischemia and, accordingly, impaired outcomes. At the same time, deferring coronary intervention in those lesions that do not show ischemic FFR values has proven safe and not associated with adverse events. Despite a major randomized clinical trial (RCT) and several non-randomized studies showing that FFR-guided revascularization could be superior to isolated angiography in improving clinical outcomes, subsequent RCTs have reported conflicting results. In this review, we summarize the principles behind FFR and the data currently available in the literature, highlighting the main differences between randomized and non-randomized studies that investigated this topic. Full article
(This article belongs to the Special Issue Diagnosis of Ischaemic Heart Disease)

Other

Jump to: Research, Review

22 pages, 1902 KiB  
Systematic Review
The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer’s Disease Spectrum: A Systematic Review and Meta-Analysis
by Efthymia Maria Kapasouri, Diomidis C. Ioannidis, Donnie Cameron, Vassilios S. Vassiliou and Michael Hornberger
Diagnostics 2022, 12(12), 2967; https://doi.org/10.3390/diagnostics12122967 - 27 Nov 2022
Cited by 5 | Viewed by 1828
Abstract
We sought to systematically review and meta-analy the role of cerebral blood flow (CBF) in the medial temporal lobe (MTL) using arterial spin labeling magnetic resonance imaging (ASL-MRI) and compare this in patients with Alzheimer’s disease (AD), individuals with mild cognitive impairment (MCI), [...] Read more.
We sought to systematically review and meta-analy the role of cerebral blood flow (CBF) in the medial temporal lobe (MTL) using arterial spin labeling magnetic resonance imaging (ASL-MRI) and compare this in patients with Alzheimer’s disease (AD), individuals with mild cognitive impairment (MCI), and cognitively normal adults (CN). The prevalence of AD is increasing and leading to high healthcare costs. A potential biomarker that can identify people at risk of developing AD, whilst cognition is normal or only mildly affected, will enable risk-stratification and potential therapeutic interventions in the future. All studies investigated the role of CBF in the MTL and compared this among AD, MCI, and CN participants. A total of 26 studies were included in the systematic review and 11 in the meta-analysis. Three separate meta-analyses were conducted. Four studies compared CBF in the hippocampus of AD compared with the CN group and showed that AD participants had 2.8 mL/min/100 g lower perfusion compared with the CN group. Eight studies compared perfusion in the hippocampus of MCI vs. CN group, which showed no difference. Three studies compared perfusion in the MTL of MCI vs. CN participants and showed no statistically significant differences. CBF measured via ASL-MRI showed impairment in AD compared with the CN group in subregions of the MTL. CBF difference was significant in hippocampus between the AD and CN groups. However, MCI and CN group showed no significant difference in subregions of MTL. Full article
(This article belongs to the Special Issue Diagnosis of Ischaemic Heart Disease)
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