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Diagnostics
Special Issues
Advances in Diagnosis of Acute Ischemic Stroke
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Advances in Diagnosis of Acute Ischemic Stroke

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2234

Special Issue Editors

Prof. Dr. Gabriel Broocks

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Guest Editor
Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Interests: stroke imaging; stroke imaging biomarkers; stroke neurointervention
Prof. Dr. Andre Kemmling

E-Mail Website
Guest Editor
Department of Neuroradiology, University Medical Center Marburg, Marburg, Germany
Interests: stroke imaging; interventional neuroradiology

Special Issue Information

Dear Colleagues,

Neuroimaging in the triage of ischemic stroke has significantly evolved over the past few years, especially regarding the timely identification of patients benefiting from thrombolytic and endovascular treatment. New imaging techniques have been established, such as automated computed tomography (CT) perfusion tools, or spectral CT techniques. Neuroimaging is increasingly used to guide a patient-specific individual treatment, rather than selection for treatment by rigid criteria. Nonetheless, different diagnostic approaches for stroke triage exist in different stroke centers. The aim of this Special Issue is to discuss recent advances in diagnostic approaches in stroke imaging. Research data, new concepts, and discussions of potential interventions that modify disease response in an ischemic stroke context will be considered. Original papers, systematic reviews, and meta-analyses are welcome.

Prof. Dr. Gabriel Broocks
Prof. Dr. Andre Kemmling
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • ischemia
  • imaging
  • computed tomography
  • magnetic resonance imaging

Published Papers (1 paper)

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Research

12 pages, 1701 KiB  
Article
Value of CT Perfusion for Collateral Status Assessment in Patients with Acute Ischemic Stroke
by Haryadi Prasetya, Manon L. Tolhuisen, Miou S. Koopman, Manon Kappelhof, Frederick J. A. Meijer, Lonneke S. F. Yo, Geert J. Lycklama á Nijeholt, Wim H. van Zwam, Aad van der Lugt, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Ed T. van Bavel, Henk A. Marquering and on behalf of the MR CLEAN Registry Investigators
Diagnostics 2022, 12(12), 3014; https://doi.org/10.3390/diagnostics12123014 - 1 Dec 2022
Cited by 4 | Viewed by 1791
Abstract
Good collateral status in acute ischemic stroke patients is an important indicator for good outcomes. Perfusion imaging potentially allows for the simultaneous assessment of local perfusion and collateral status. We combined multiple CTP parameters to evaluate a CTP-based collateral score. We included 85 [...] Read more.
Good collateral status in acute ischemic stroke patients is an important indicator for good outcomes. Perfusion imaging potentially allows for the simultaneous assessment of local perfusion and collateral status. We combined multiple CTP parameters to evaluate a CTP-based collateral score. We included 85 patients with a baseline CTP and single-phase CTA images from the MR CLEAN Registry. We evaluated patients’ CTP parameters, including relative CBVs and tissue volumes with several time-to-maximum ranges, to be candidates for a CTP-based collateral score. The score candidate with the strongest association with CTA-based collateral score and a 90-day mRS was included for further analyses. We assessed the association of the CTP-based collateral score with the functional outcome (mRS 0–2) by analyzing three regression models: baseline prognostic factors (model 1), model 1 including the CTA-based collateral score (model 2), and model 1 including the CTP-based collateral score (model 3). The model performance was evaluated using C-statistic. Among the CTP-based collateral score candidates, relative CBVs with a time-to-maximum of 6–10 s showed a significant association with CTA-based collateral scores (p = 0.02) and mRS (p = 0.05) and was therefore selected for further analysis. Model 3 most accurately predicted favorable outcomes (C-statistic = 0.86, 95% CI: 0.77–0.94) although differences between regression models were not statistically significant. We introduced a CTP-based collateral score, which is significantly associated with functional outcome and may serve as an alternative collateral measure in settings where MR imaging is not feasible. Full article
(This article belongs to the Special Issue Advances in Diagnosis of Acute Ischemic Stroke)
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