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Diagnostics
Special Issues
Acute Myocardial Infarction: Diagnosis and Management
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Acute Myocardial Infarction: Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (25 March 2023) | Viewed by 1543

Special Issue Editor

Dr. Elad Asher

E-Mail Website
Guest Editor
Department of Cardiology, Jesselson Integrated Heart Center, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
Interests: ACS; interventional cardiology; OCT; platelets; PE; cardiogenic shock
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality in the developed world with a prevalence of approximately three million people worldwide despite substantial improvements in prognosis over the past decade. This improvement is a result of several major trends, including risk stratification, the use of early invasive strategy through percutaneous coronary intervention (PCI), the use of mechanical support devices in cardiogenic shock complicating AMI, better antiplatelet agents and anticoagulants, and better knowledge about the importance of secondary prevention strategies (such as statins). AMI can be divided into two categories, i.e., non-ST segment elevation MI (NSTEMI) and ST segment elevation MI (STEMI), although new categories (such as acute coronary occlusion MI (OMI) vs. non-occlusion MI (NOMI)) have also been suggested.

This Special Issue aims to provide a comprehensive picture on this dynamic research area by gathering contributions that cover all aspects related to the topic, including the diagnosis (e.g., ECG, troponin, novel biomarkers, artificial intelligence, nationwide surveys, etc.) and management of AMI; cardiogenic shock complicating AMI (e.g., primary PCI, mechanical support devices [e.g., primary PCI, mechanical support devices (such as Impella, extracorporeal membrane oxygenation, intra-aortic balloon pump), transcatheter aortic valve implantation and Mitral clips in the setting of AMI, anti-platelet agents and anticoagulants, PCSK-9 inhibitor statins]; and short- and long-term prognosis of AMI (e.g., trends, nationwide surveys, and future perspective).  

Contributions may be related to any aspect of AMI and should expand on the knowledge surrounding such topics.

Dr. Elad Asher
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute myocardial infarction 
  • STEMI 
  • NSTEMI 
  • primary percutaneous coronary intervention 
  • cardiogenic shock 
  • mechanical support devices 
  • anti-platelet 
  • thrombus 
  • troponin 
  • ECG

Published Papers (1 paper)

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Research

7 pages, 2551 KiB  
Article
Temporal Trends in the Prevalence, Treatment and Outcomes of Patients with Acute Coronary Syndrome at High Bleeding Risk
by Ziad Arow, Tal Ovdat, Mustafa Gabarin, Alexander Omelchenko, Mony Shuvy, Tsafrir Or, Abid Assali and David Pereg
Diagnostics 2022, 12(8), 1784; https://doi.org/10.3390/diagnostics12081784 - 22 Jul 2022
Viewed by 1032
Abstract
(1) Background: High bleeding risk is associated with adverse outcomes in ACS patients. We aimed to evaluate temporal trends in treatment and outcomes of ACS patients according to bleeding risk. (2) Methods: Included were ACS patients enrolled in ACSIS surveys. Patients were divided [...] Read more.
(1) Background: High bleeding risk is associated with adverse outcomes in ACS patients. We aimed to evaluate temporal trends in treatment and outcomes of ACS patients according to bleeding risk. (2) Methods: Included were ACS patients enrolled in ACSIS surveys. Patients were divided into three groups according to enrolment period: early (2002–2004), mid (2006–2010) and recent (2012–2018). Each group was further stratified into three subgroups according to CRUSADE bleeding risk score. The primary endpoints were 30-day MACE and 1-year all-cause mortality. (3) Results: Included were 13,058 ACS patients. High bleeding risk patients were less frequently treated with guideline-based medications and coronary revascularization. They also had higher rates of 30-day MACE and 1-year all-cause mortality regardless of the enrollment period. Among patients enrolled in early period, 30-day MACE rates were 10.8%, 17.5% and 24.3% (p < 0.001) and 1-year all-cause mortality rates were 2%, 7.7% and 23.6% (p < 0.001) in the low, moderate and high bleeding risk groups, respectively. Among patients enrolled in mid period, 30-day MACE rates were 7.7%, 13.4% and 23.5% (p < 0.001) and 1-year all-cause mortality rates were 1.5%, 7.2% and 22.1% (p < 0.001) in low, moderate and high bleeding risk groups, respectively. For patients enrolled in recent period, 30-day MACE rates were 5.7%, 8.6% and 16.2%, (p < 0.001) and 1-year all-cause mortality rates were 2.1%, 6% and 22.4%, (p < 0.001) in low, moderate and high bleeding risk groups, respectively. These differences remained significant following a multivariate analysis. (4) Conclusions: The percentage of patients at high bleeding risk has decreased over the last years. Despite recent improvements in the treatment of ACS patients, high bleeding risk remains a strong predictor of adverse outcomes. Full article
(This article belongs to the Special Issue Acute Myocardial Infarction: Diagnosis and Management)
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