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Diagnostics
Special Issues
Imaging Research on Gastrointestinal Disorders
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Imaging Research on Gastrointestinal Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 4175

Special Issue Editor

Dr. Takahiro Emoto

E-Mail Website
Guest Editor
Graduate School of Sciences and Technology, Tokushima University, Tokushima, Japan
Interests: biomedical engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to an in-depth exploration of imaging studies of gastrointestinal diseases. Gastrointestinal diseases comprise a complex and diverse group of diseases of which the diagnosis and treatment require a comprehensive multidisciplinary approach. The Special Issue covers the imaging manifestations of various gastrointestinal diseases, including, but not limited to, inflammatory bowel disease, intestinal obstruction, irritable bowel syndrome, gastric cancer, colorectal cancer, etc. In addition, the Special Issue will also delve into the specific applications of imaging in gastrointestinal diseases, including, but not limited to, CT, MRI, ultrasound, endoscopy, etc.

Overall, we aim to provide an all-round, multi-angle platform for readers to gain an in-depth understanding of the current status and development trends of imaging research on gastrointestinal diseases. We look forward to your participation and contribution to jointly promote the advancement of imaging research in gastrointestinal diseases.

Dr. Takahiro Emoto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal diseases
  • inflammatory bowel disease
  • intestinal obstruction
  • irritable bowel syndrome
  • gastric cancer
  • signal and image processing
  • visualization techniques for the gastrointestinal tract

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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11 pages, 573 KiB  
Article
Diagnostic Yield and Outcomes of Small Bowel Capsule Endoscopy in Patients with Small Bowel Bleeding Receiving Antithrombotics
by Nikos Viazis, Dimitris Christodoulou, Vasilis Papastergiou, Konstantinos Mousourakis, Dimitra Kozompoli, Giannis Stasinos, Konstantina Dimopoulou, Periklis Apostolopoulos, Fotios Fousekis, Christos Liatsos, Nikolaos Kyriakos, Theodoros Argyropoulos and George Tribonias
Diagnostics 2024, 14(13), 1361; https://doi.org/10.3390/diagnostics14131361 - 27 Jun 2024
Cited by 1 | Viewed by 1514
Abstract
We aimed to determine the diagnostic yield and outcome of patients receiving antithrombotic drug therapy subjected to small bowel capsule endoscopy (SBCE) for the investigation of small bowel bleeding (SBB). A multicenter retrospective analysis of collected data from all patients undergoing SBCE for [...] Read more.
We aimed to determine the diagnostic yield and outcome of patients receiving antithrombotic drug therapy subjected to small bowel capsule endoscopy (SBCE) for the investigation of small bowel bleeding (SBB). A multicenter retrospective analysis of collected data from all patients undergoing SBCE for the investigation of SBB from March 2003 to June 2023 was performed. The diagnostic yield of SBCE was defined as the detection of positive findings that could explain the cause of the patient’s bleeding. Rebleeding was defined as evidence of bleeding within 1 year after the index episode. During the study period, 8401 patients underwent SBCE for SBB investigation. Bleeding lesions were detected in 1103/2535 (43.5%) antithrombotic users, compared to 1113/5866 (18.9%) in nonusers (p < 0.00001). Following capsule endoscopy, a therapeutic intervention was possible in 390/2216 (17.5%) patients with a bleeding lesion. Rebleeding occurred in 927 (36.5%) of antithrombotic users (36.5%), compared to 795 (13.5%) of nonusers (13.5%, p < 0.00001). Both the diagnostic yield of SBCE and the rebleeding rates were higher in patients with SBB receiving antithrombotics. Therapeutic intervention was possible in a real-world setting only for a minority of patients with positive findings. Full article
(This article belongs to the Special Issue Imaging Research on Gastrointestinal Disorders)
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12 pages, 11263 KiB  
Article
Risk Factors for Mucosal Redness in the Duodenal Bulb as Detected via Linked Color Imaging
by Tsutomu Takeda, Daiki Abe, Daisuke Asaoka, Tomoyo Iwano, Momoko Yamamoto, Ryota Uchida, Hisanori Utsunomiya, Shotaro Oki, Nobuyuki Suzuki, Atsushi Ikeda, Yoichi Akazawa, Kumiko Ueda, Hiroya Ueyama, Mariko Hojo, Shuko Nojiri and Akihito Nagahara
Diagnostics 2024, 14(5), 508; https://doi.org/10.3390/diagnostics14050508 - 28 Feb 2024
Viewed by 1912
Abstract
Linked color imaging (LCI) for image-enhanced endoscopy (IEE) highlights mucosal color differences. We investigated risk factors associated with mucosal redness of the duodenal bulb using LCI. Consecutive patients were retrospectively selected after their duodenal bulbs were observed via LCI. A symptom questionnaire (Izumo [...] Read more.
Linked color imaging (LCI) for image-enhanced endoscopy (IEE) highlights mucosal color differences. We investigated risk factors associated with mucosal redness of the duodenal bulb using LCI. Consecutive patients were retrospectively selected after their duodenal bulbs were observed via LCI. A symptom questionnaire (Izumo scale) was completed. The LCI of the duodenal bulb was subjectively evaluated on whether redness was present and objectively evaluated based on L* a* b* color values. The clinical characteristics of the 302 study participants were: male/female, 120/182; mean age, 70.9 years. Twenty-one cases (7.0%) were in the redness (+) group. After multiple regression analysis, independent predictors for the red component (a*) of the duodenal bulb using LCI were: age (β = −0.154, p < 0.01), female (β = −0.129, p < 0.05), body mass index (BMI; β = −0.136, p < 0.05), Helicobacter pylori eradication (β = 0.137, p < 0.05), endoscopic gastric mucosal atrophy score (EGAS; β = −0.149, p < 0.05), and constipation-related quality of life (QOL) (β = −0.122, p < 0.05) scores. Lower age, lower BMI, lower EGAS, a constipation-related QOL score, post-H. pylori eradication, and being male were associated with mucosal redness in the duodenal bulb with IEE using LCI. Full article
(This article belongs to the Special Issue Imaging Research on Gastrointestinal Disorders)
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Other

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3 pages, 314 KiB  
Interesting Images
Interesting Images: Endocytoscopy for In Vivo Diagnosis of Intestinal Graft-Versus-Host Disease
by Timo Rath, Till Orlemann, Francesco Vitali, Abbas Agaimy, Andreas Mackensen and Markus F. Neurath
Diagnostics 2025, 15(13), 1595; https://doi.org/10.3390/diagnostics15131595 - 24 Jun 2025
Viewed by 185
Abstract
Gastrointestinal graft-versus-host disease (GvHD) is a frequent and severe complication after allogeneic stem cell transplantation (aSCTx). Although biopsy and histopathology remain the gold standard for diagnosis of GvHD, this approach can be limited by thrombocytopenia accompanying aSCTx and the diagnostic delay associated with [...] Read more.
Gastrointestinal graft-versus-host disease (GvHD) is a frequent and severe complication after allogeneic stem cell transplantation (aSCTx). Although biopsy and histopathology remain the gold standard for diagnosis of GvHD, this approach can be limited by thrombocytopenia accompanying aSCTx and the diagnostic delay associated with routine histopathology. Here, we report on two patients in which dye-based contact microscopy using a latest generation endocytoscope with 520-fold magnification enabled in vivo diagnosis of GvHD. The first patient was a 23-year-old man with acute lymphoblastic leukemia presenting with non-bloody diarrhea 3 months after aSCTx. After topical staining with crystal violet and methylene blue, endocytoscopy in the rectum showed several apoptotic epithelial cells. Histopathology confirmed GvHD grade III according to the Lerner classification. The second patient was a 59-year-old female with diarrhea 3 months after aSCTx. Apart from pathognomic apoptotic bodies, EC additionally revealed crypt lumina enlargement and mononuclear cell infiltrates in the lamina propria with subsequent crypt distension. The duration of the procedure was less than 5 min in each patient. These findings illustrate that in vivo microscopy using endocytoscopy can enable instantaneous diagnosis of GvHD with the benefit of accelerating therapeutic decisions in patients with suspected severe GvHD. Full article
(This article belongs to the Special Issue Imaging Research on Gastrointestinal Disorders)
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