Diagnosis, Management, and Prognosis of Liver Disease and Its Syndromes
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 9554
Special Issue Editor
2. College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Interests: chemoembolization; portal vein; chronic liver failure; liver disease; viral hepatitis
Special Issue Information
Dear Colleagues,
The prompt and accurate diagnosis, management, and prognosis of acute and chronic liver disease and its associated syndromes, such as cirrhosis-associated immune dysfunction syndrome (CAIDS) or acute-on-chronic liver failure (ACLF), are of the utmost importance. The delayed or inaccurate diagnosis, management, and prognosis of acute and chronic liver disease or its related syndromes lead to increased morbidity and mortality. For example, the early diagnosis of hepatitis B (HBV) flare through the identification of elevated ALT and HBV-DNA and the subsequent application of antiviral therapy can reduce the risk of severe hepatitis flares and even HBV-ACLF. In a similar vein, prompt diagnostic paracentesis, combined with appropriate antibiotic therapy, can reduce the risk of in-hospital mortality among patients with suspected spontaneous bacterial peritonitis. Furthermore, accurate prognostic markers can help us to identify patients at risk or those of a futile status, such as patients with ACLF and high CLIF-C ACLF scores (≥70) who, after 48 hours of intensive care, may reach the threshold of futility for further ongoing intensive support. The best treatment options in this scenario remain to be determined but may include palliative care.
This Special Issue on the “Diagnosis, Management, and Prognosis of Liver Disease and Its Syndromes” covers all aspects addressed in the studies and reviews on the well-established diagnosis, management, and prognosis of acute/chronic liver disease and its syndromes, as well as new diagnostic tools, the development of treatment modalities, and novel prognostic markers. Examples of such markers include obeticholic acid or semaglutide for non-alcoholic steatohepatitis (NASH) and the neutrophil-to-lymphocyte ratio (NLR) as an indicator of the severity of steatosis and fibrosis.
Prof. Dr. Chien Hao Huang
Guest Editor
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Keywords
- acute liver disease
- chronic liver disease
- viral hepatitis
- liver cirrhosis
- non-alcoholic steatohepatitis (NASH)
- diagnosis
- treatment
- prognosis score
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