Endoscopic Ultrasound Guided Techniques in Pancreatic Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 3447

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Gastroenterology and Digestive Endoscopy Unit, ASST Rhodense, 20094 Garbagnate Milanese, Italy
Interests: endoscopy; gastric cancer; pancreatic diseases; gastrointestinal diseases
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Special Issue Information

Dear Colleagues,

Pancreatic cancer is the second-most-frequent gastrointestinal malignancy and carries a poor quality of life and prognosis. The current standard of care is surgery resection, if possible, as well as systemic chemoradiation therapy in locally advanced, unresectable disease. Endoscopic ultrasound (EUS) is a well-established and valid technique for the diagnosis and staging of pancreatic cancer. Therapeutic EUS for the treatment of pancreatic neoplastic lesions is a rapidly expanding field with different options, including fine needle injection therapy, radiofrequency, cryothermal ablation and brachytherapy. A complete review of alternative EUS-guided ablative techniques will be extremely valuable in providing new directions for upcoming research.

Dr. Germana De Nucci
Guest Editor

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Keywords

  • pancreatic cancer
  • neuroendocrine tumor
  • endoscopy ultrasound
  • radiofrequency ablation
  • fine needle injection therapy
  • cryothermal ablation
  • therapeutic endoscopy
  • pancreas

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Published Papers (2 papers)

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Review

18 pages, 2464 KiB  
Review
Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction: A Comprehensive Review on Technical Tips and Clinical Outcomes
by Stefano Mazza, Graziella Masciangelo, Aurelio Mauro, Davide Scalvini, Francesca Torello Viera, Marco Bardone, Letizia Veronese, Laura Rovedatti, Simona Agazzi, Elena Strada, Lodovica Pozzi, Chiara Barteselli, Carmelo Sgarlata, Valentina Ravetta, Pietro Fusaroli and Andrea Anderloni
Diagnostics 2024, 14(23), 2644; https://doi.org/10.3390/diagnostics14232644 - 24 Nov 2024
Cited by 1 | Viewed by 1116
Abstract
Endoscopic ultrasound-guided biliary drainage (EUS-BD) has dramatically spread and improved in the last two decades and is changing the paradigm of drainage in case of malignant biliary obstruction (MBO). EUS-BD can be achieved from different routes, including the common bile duct (choledochoduodenostomy), intrahepatic [...] Read more.
Endoscopic ultrasound-guided biliary drainage (EUS-BD) has dramatically spread and improved in the last two decades and is changing the paradigm of drainage in case of malignant biliary obstruction (MBO). EUS-BD can be achieved from different routes, including the common bile duct (choledochoduodenostomy), intrahepatic bile ducts (hepaticogastrostomy), and gallbladder as a rescue (cholecystogastrostomy/cholecystoduodenostomy). EUS-guided hepaticogastrostomy (EUS-HGS) is a valuable option for biliary drainage in MBO when ERCP fails or is not feasible. EUS-HGS has demonstrated high efficacy with a good rate of technical and clinical success. The safety profile is also overall favorable, although severe adverse events may occur in a significant proportion of patients. From a technical perspective, EUS-HGS is considered one of the most demanding procedures in biliopancreatic endoscopy, requiring multiple steps and high technical skills and experience. In this comprehensive review, technical tips and clinical outcomes of EUS-HGS are reviewed according to the latest evidence in the literature. Full article
(This article belongs to the Special Issue Endoscopic Ultrasound Guided Techniques in Pancreatic Diseases)
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20 pages, 14243 KiB  
Review
EUS-Guided Radiofrequency Ablation Therapy for Pancreatic Neoplasia
by Mihai Rimbaș, Andra-Cristiana Dumitru, Giulia Tripodi and Alberto Larghi
Diagnostics 2024, 14(19), 2111; https://doi.org/10.3390/diagnostics14192111 - 24 Sep 2024
Cited by 1 | Viewed by 1840
Abstract
Radiofrequency ablation (RFA) under endoscopic ultrasound (EUS) guidance has been developed and utilized over the last decade to provide the loco-regional treatment of solid and cystic pancreatic neoplastic lesions. The advantage of this approach relies on the close proximity of the EUS transducer [...] Read more.
Radiofrequency ablation (RFA) under endoscopic ultrasound (EUS) guidance has been developed and utilized over the last decade to provide the loco-regional treatment of solid and cystic pancreatic neoplastic lesions. The advantage of this approach relies on the close proximity of the EUS transducer to the target pancreatic lesion, which, coupled with the development of specifically designed RFA ablation devices, has made the procedure minimally invasive, with a clear reduction in adverse events as compared to the high morbidity of the surgical approach. EUS-RFA has been applied so far to pancreatic functional and non-functional neuroendocrine neoplasms, pancreatic ductal adenocarcinoma or metastases to the pancreas, and pancreatic neoplastic cysts. Excluding neuroendocrine tumors, for other indications, most of these procedures have been performed in patients who refused surgery or were at high surgical risk. More studies evaluating EUS-RFA in selected patients, not at surgical risk, are gradually becoming available and will pave the road to extend the indications for this therapeutic approach, also in association with other oncological therapies. The present manuscript will critically review the available evidence in the field of the EUS-guided RFA of solid and cystic pancreatic neoplasms. Full article
(This article belongs to the Special Issue Endoscopic Ultrasound Guided Techniques in Pancreatic Diseases)
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