Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
3.0
Journals
Diagnostics
Special Issues
Screening and Diagnostic Testing of Keratoconus
share announcement

Screening and Diagnostic Testing of Keratoconus

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2058

Special Issue Editors

Dr. Cristina Nicula

E-Mail Website
Guest Editor
Department of Oral-Maxilo-Facial Surgery, Faculty of Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
Interests: cataract extraction; eye diseases; cataract; dry eye syndromes; presbyopia; blepharitis; keratoconjunctivitis sicca; keratoconus
Prof. Dr. Adriana Elena Bulboaca

E-Mail Website
Guest Editor
Pathophysiology Department, Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca, Cluj Napoca, Romania
Interests: nanomedicine; oxidative and nitrosative stress; inflammation; neuroophthalmology; ocular surface disorders mechanisms; retinal diseases mechanisms; nutraceuticals; translational medicine; personalized medicine

Special Issue Information

Dear Colleagues,

Keratoconus is a bilateral, asymmetric, ectatic corneal disorder characterized by progressive corneal thinning and steepening that may result in significant visual loss in the later stages. The disease onset is seen during the second decade of life, with fast evolution during this period. That is why the early detection and screening of keratoconus are crucial for disease management. To date, corneal topography has been the “gold standard” method of diagnosis. Moreover, corneal tomography is considered a better option for screening for the illness because it gives information on both the anterior and posterior surface of the cornea. Lately, corneal biomechanics provided by the Corvis device have highlighted the option for subclinical keratoconus diagnosis in the early stages of the illness.

Dr. Cristina Nicula
Prof. Dr. Adriana Elena Bulboaca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • keratoconus
  • eye diseases
  • vision problems
  • visual acuity test
  • refraction test
  • slit-lamp examination
  • tonometry
  • dilated fundus examination
  • visual field testing
  • anterior segment imaging
  • posterior segment imaging

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

10 pages, 455 KiB  
Article
Pilot Programme for Keratoconus Screening and Management in Adolescents with Down Syndrome
by Barry Power, Kirk A. J. Stephenson, Diana Malata, Conor Murphy, Barry Quill, Fiona McGrane, Eleanor Molloy and William Power
Diagnostics 2025, 15(6), 683; https://doi.org/10.3390/diagnostics15060683 - 10 Mar 2025
Viewed by 528
Abstract
Background/Objectives: To screen a group of adolescents with Down Syndrome (Trisomy 21) for keratoconus and assess the feasibility of setting up a national screening service. Methods: Twenty-seven patients with Down Syndrome between 9 and 18 years of age attended our pilot [...] Read more.
Background/Objectives: To screen a group of adolescents with Down Syndrome (Trisomy 21) for keratoconus and assess the feasibility of setting up a national screening service. Methods: Twenty-seven patients with Down Syndrome between 9 and 18 years of age attended our pilot keratoconus screening clinic. We recorded demographics, medical history, risk factors, best-corrected distance visual acuity, clinical examination results and corneal tomography results. The presence of keratoconus was confirmed by one of three corneal specialists based on clinical and tomographic findings. Tomographic analysis included zonal Kmax, thinnest point, inferior–superior asymmetry (IS Values), Belin/Ambrosio deviation value (BAD-D) and anterior and posterior elevation maps. Results: Early keratoconus was detected on tomography in 8 out of 54 eyes (15%) at the first review. These eyes were listed for crosslinking. The mean age of diagnosis was 14.6. Corneas in the Down Syndrome screening group were thinner and steeper (mean central corneal thickness (CCT) 479 µm vs. 536 µm and mean Kmax 49.2D vs. 45.8D, respectively) than healthy, age-matched controls from the literature. Conclusions: Fifteen percent of eyes (5 out of 27 patients) screened had tomographic evidence of keratoconus requiring treatment at their first review. We found an increased incidence of keratoconus in European individuals with Down Syndrome. Screening this vulnerable, high-risk population with corneal tomography can diagnose early keratoconus and enable corneal crosslinking to safely and effectively stabilise the disease. We advocate tomographic keratoconus screening for individuals with Down Syndrome in their mid-teens. Full article
(This article belongs to the Special Issue Screening and Diagnostic Testing of Keratoconus)
►▼ Show Figures

Figure 1

13 pages, 1879 KiB  
Article
Relationship between Choroidal Thickness and Anterior Scleral Thickness in Patients with Keratoconus
by Neus Burguera-Giménez, M.ª Amparo Díez-Ajenjo, Celeste Briceno-Lopez, Noemí Burguera, M.ª José Luque-Cobija and Cristina Peris-Martínez
Diagnostics 2024, 14(20), 2280; https://doi.org/10.3390/diagnostics14202280 - 14 Oct 2024
Viewed by 1044
Abstract
Purpose: To evaluate the relationship between choroidal thickness (CT) and anterior scleral thickness (AST) in patients with subclinical keratoconus (SKC) and established keratoconus (KC). Methods: This single-center prospective case-control study included 97 eyes of 97 patients: 44 KC eyes, 14 SKC eyes, and [...] Read more.
Purpose: To evaluate the relationship between choroidal thickness (CT) and anterior scleral thickness (AST) in patients with subclinical keratoconus (SKC) and established keratoconus (KC). Methods: This single-center prospective case-control study included 97 eyes of 97 patients: 44 KC eyes, 14 SKC eyes, and 39 age- and axial length (AL)-matched healthy eyes. Using swept-source optical coherence tomography, the AST was manually measured in four directions and the CT was obtained automatically from the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. Principal component analysis (PCA) was used to linearly reduce the dimensionality of nine CT inputs to one significant component, CT1. A multivariate model was created to evaluate the association between CT1, AST, and several ocular parameters in SKC and KC patients. Partial correlation was then performed to adjust the confounding factors and to examine the effect of AST on CT1. Results: The PCA showed that CT1 accounts for 86.54% of the total variance in the nine original CTs of the ETDRS grid. The CT1 model was associated with age, AL, and AST in the superior meridian in SKC eyes, whereas in KC eyes, it was correlated with gender, age, AL, and AST in the inferior meridian (p < 0.001). The partial correlation between CT1 and AST in the superior zone was found to be significant, positive, and strong in SKC eyes (r = 0.79, p = 0.019), whereas a significant, positive, and moderate correlation between CT1 and AST at the inferior zone (r = 0.41, p = 0.017) was observed in KC eyes. Conclusions: Choroidal tissue was significantly correlated with the anterior sclera across the vertical meridian. This relationship was observed over the superior sclera in SKC eyes, whereas in established KC, it was over the inferior sclera. These results reveal new insights regarding the interactions between the anterior and posterior structures of the KC eyes and confirm the enigma of the pathophysiology of KC. Full article
(This article belongs to the Special Issue Screening and Diagnostic Testing of Keratoconus)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop