Clinical Management of Lung Cancer Brain Metastases

A special issue of Current Oncology (ISSN 1718-7729).

Deadline for manuscript submissions: 30 June 2026 | Viewed by 15

Special Issue Editor


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Guest Editor
Division of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Interests: lung, head-neck and brain malignancies; improving outcomes; quality of life; clinical trials and meta-analysis

Special Issue Information

Dear Colleagues,

Brain metastases represent one of the most challenging complications of lung cancer, significantly contributing to morbidity and mortality. Current clinical management strategies include surgery, radiotherapy, systemic therapy, and newer targeted and immunotherapeutic approaches. Each of these modalities, however, has important limitations. Surgical resection, while potentially effective for selected patients, is often not feasible in cases of multiple or inoperable lesions. Radiotherapy, including whole brain radiotherapy, stereotactic radiosurgery, and stereotactic body radiotherapy, improves local control but carries the risk of neurocognitive decline and damage to normal brain tissue. Systemic chemotherapy, though widely used, is limited by its poor blood–brain barrier penetration and modest efficacy. Targeted therapies and immunotherapies have transformed the treatment landscape for subsets of patients, yet resistance mechanisms and variable intracranial response rates remain significant challenges.

These limitations highlight the need for better prognostic models and integrative strategies to optimize treatment selection and improve outcomes. Advances in molecular profiling, imaging, and predictive biomarkers hold promise in refining risk stratification and guiding personalized therapy.

In this Special Issue, we invite original research articles and reviews addressing the clinical management of lung cancer brain metastases. Contributions focusing on novel therapeutic approaches, mechanisms of resistance, prognostic and predictive factors, and multidisciplinary strategies are particularly encouraged. Through this Special Issue, we will foster new insights into treatment modalities and prognostic models that will enhance the care of patients with this complex and evolving condition.

We look forward to receiving your contributions.

Dr. Shrinivas Rathod
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung cancer brain metastases
  • clinical management
  • radiotherapy techniques
  • targeted therapy
  • immunotherapy
  • multidisciplinary management
  • clinical trials

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Published Papers

This special issue is now open for submission.
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