Clinical Management of Lung Cancer Brain Metastases
A special issue of Current Oncology (ISSN 1718-7729).
Deadline for manuscript submissions: 30 June 2026 | Viewed by 71
Special Issue Editor
Special Issue Information
Dear Colleagues,
Brain metastases represent one of the most challenging complications of lung cancer, significantly contributing to morbidity and mortality. Current clinical management strategies include surgery, radiotherapy, systemic therapy, and newer targeted and immunotherapeutic approaches. Each of these modalities, however, has important limitations. Surgical resection, while potentially effective for selected patients, is often not feasible in cases of multiple or inoperable lesions. Radiotherapy, including whole brain radiotherapy, stereotactic radiosurgery, and stereotactic body radiotherapy, improves local control but carries the risk of neurocognitive decline and damage to normal brain tissue. Systemic chemotherapy, though widely used, is limited by its poor blood–brain barrier penetration and modest efficacy. Targeted therapies and immunotherapies have transformed the treatment landscape for subsets of patients, yet resistance mechanisms and variable intracranial response rates remain significant challenges.
These limitations highlight the need for better prognostic models and integrative strategies to optimize treatment selection and improve outcomes. Advances in molecular profiling, imaging, and predictive biomarkers hold promise in refining risk stratification and guiding personalized therapy.
In this Special Issue, we invite original research articles and reviews addressing the clinical management of lung cancer brain metastases. Contributions focusing on novel therapeutic approaches, mechanisms of resistance, prognostic and predictive factors, and multidisciplinary strategies are particularly encouraged. Through this Special Issue, we will foster new insights into treatment modalities and prognostic models that will enhance the care of patients with this complex and evolving condition.
We look forward to receiving your contributions.
Dr. Shrinivas Rathod
Guest Editor
Manuscript Submission Information
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Keywords
- lung cancer brain metastases
- clinical management
- radiotherapy techniques
- targeted therapy
- immunotherapy
- multidisciplinary management
- clinical trials
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