Natural Ingredients with Bioactive Properties, and Its Potential Application in Cosmetics

A special issue of Cosmetics (ISSN 2079-9284).

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 26014

Special Issue Editors


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Guest Editor
Department of Biotechnology and Food Technology, Southern Taiwan University of Science and Technology, No. 1, Nan-Tai Street, Yungkang Dist., Tainan City 710301, Taiwan
Interests: functional evaluation of health ingredients; utilization of vegetable and fruit waste resources; functional processed products; food hygiene and safety

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Department of Medicinal Botanical and Health Applications, Da-Yeh University, Changhua 51591, Taiwan
Interests: nanoemulsions; transdermal delivery system; marine-derived material for cosmetics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of cosmetics and health care, Chung-Jen Junior College of Nursing, Health Sciences and Management, No 217, Hung-Mao-Pi, Chia-Yi City 60077, Taiwan

Special Issue Information

Dear Colleagues,

The importance of natural ingredients endowed with antioxidant and anti-inflammatory properties to be used in cosmetics is progressively increasing. Indeed, these compounds can counteract the damages induced by free radicals and reactive oxygen species on skin cells, involved, e.g., in wrinkling, photo-aging, elastosis, drying, and hyperpigmentation of the skin.

This Special Issue is dedicated to natural compounds with anti-inflammatory and antioxidant actions and their potential for application in skincare formulations and cosmetics. Original research articles dealing with the elucidation of mechanisms of action, therapeutic effectiveness, and safety aspects in the application of such biologically active natural compounds are encouraged. Manuscripts describing the development of novel formulations allowing for a higher stability and bioavailability of bioactive compounds are also welcome. Attention will also be devoted to green and sustainable approaches for the recovery of antioxidant and anti-inflammatory compounds from natural sources to be used in cosmetic products, as well as to bioprocessing and green chemistry solutions to improve their bioactivity. In the case of plant-derived extracts, structural characterization and identification of the main bioactive components will be required. Review articles describing the current state of the art are also welcome.

Dr. Da-Wei Huang
Dr. Po Hsien Li
Dr. Wen-Lung Kuo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (5 papers)

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Research

10 pages, 1048 KiB  
Article
Collagenase and Tyrosinase Inhibitory Activities and Stability of Facial Cream Formulation Containing Cashew Leaf Extract
by Pawalee Srisuksomwong, Lalita Kaenhin and Lapatrada Mungmai
Cosmetics 2023, 10(1), 17; https://doi.org/10.3390/cosmetics10010017 - 16 Jan 2023
Cited by 10 | Viewed by 5287
Abstract
The cashew tree (Anacardium occidentale L.) is a tropical plant found widely in many Southeast Asian countries, including Thailand, and contains bioactive phenolic compounds with antioxidant activity. The natural antioxidants such as collagenase and tyrosinase inhibitors found in medicinal plants are promising [...] Read more.
The cashew tree (Anacardium occidentale L.) is a tropical plant found widely in many Southeast Asian countries, including Thailand, and contains bioactive phenolic compounds with antioxidant activity. The natural antioxidants such as collagenase and tyrosinase inhibitors found in medicinal plants are promising agents in cosmetic products. This study evaluated the inhibitory activities of the collagenase and tyrosinase from cashew leaf extracts by developing and evaluating the stability of facial cream formulations. The ethanol (DEN), ethyl acetate (DEA) and distilled water (DDW) crude extracts of cashew leaves were investigated for their bioactive compound efficacy. The DDW extract had the highest yield (24.97%). All the extracts were investigated for their antioxidant activities. The DEN extract showed the highest DPPH radical-scavenging ability, ferric-reducing power and flavonoid compounds, which were 152.04 ± 2.40 mg gallic acid/g extract, 37.90 ± 1.07 mg gallic acid/g dry weight and 7.63 ± 0.07 mg quercetin/g dry weight, respectively. The DDW extract exhibited the highest potent activity, which was 111.00 ± 0.78 mg gallic acid/g dry weight in terms of phenolic content, while the DEN extract showed the highest tyrosinase inhibition at 0.100 mg/mL (46.97 ± 3.34%) and collagenase activity at 40 µg/mL. The results suggested that the ethanolic extracts from cashew leaves showed promise for use in skincare product development. Cosmeceutical formulations for skincare were prepared. The formula mixed with DEN extract and added to whitening and anti-aging skincare cream demonstrated good stability and physical properties. Full article
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15 pages, 2549 KiB  
Article
Evaluation of the Preliminary Safety, Tolerability and Colonisation Efficacy of Topical Probiotic Formulations Containing Micrococcus luteus Q24 in Healthy Human Adults
by Rohit Jain, Abigail L. Voss, John R. Tagg and John D. F. Hale
Cosmetics 2022, 9(6), 121; https://doi.org/10.3390/cosmetics9060121 - 16 Nov 2022
Cited by 2 | Viewed by 8943
Abstract
Probiotics developed for topical applications in humans have the potential to beneficially modulate microbial imbalances on the skin surface and thereby improve skin health. This study was conducted to determine whether topical formulations containing the human skin commensal Micrococcus luteus strain Q24 (BLIS [...] Read more.
Probiotics developed for topical applications in humans have the potential to beneficially modulate microbial imbalances on the skin surface and thereby improve skin health. This study was conducted to determine whether topical formulations containing the human skin commensal Micrococcus luteus strain Q24 (BLIS Q24) are safe, tolerable and efficacious when used by healthy human subjects. M. luteus Q24 was assessed in vitro for haemolytic activity and its antibiotic susceptibility profile. Formulations of strain Q24 were evaluated for the preliminary safety and tolerability in healthy human participants. Forty-seven adults were randomly assigned to four single-site, single-blind randomised placebo or baseline controlled or active-controlled trials. Skin swab samples were collected for differential viable counts to monitor levels of probiotic colonisation. M. luteus Q24 was found to be non-haemolytic and susceptible to commonly used antibiotics. The M. luteus Q24 formulations were safe and tolerable and >90% of the participants reported improvements from baseline in the appearance (e.g., radiance and hydration) of their treated skin. Additionally, participants observed a reduction in pore size, skin clarity and enhanced skin softness. No adverse effects were reported. A dose-related significant increase was observed in the levels of M. luteus Q24 isolated from skin swabs of the probiotic-treated subjects. Placebo-controlled trials in human subjects involving the topical application of different doses of M. luteus Q24 formulations were supportive of the safety, tolerability and efficacy of probiotic M. luteus Q24. Self-reported skin health assessments by the subjects indicated that M. luteus Q24 has good potential as a probiotic for improving skin health quality. Full article
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11 pages, 1720 KiB  
Article
Alternative Utilization of Vegetable Crop: Pumpkin Polysaccharide Extract and Their Efficacy on Skin Hydration
by Setinee Chanpirom, Nisakorn Saewan and Tawanun Sripisut
Cosmetics 2022, 9(6), 113; https://doi.org/10.3390/cosmetics9060113 - 2 Nov 2022
Viewed by 3119
Abstract
Traditional pumpkin (Cucurbita moschata) and Japanese pumpkin (C. maxima) consist of natural polysaccharides. From a scientific basis, natural polysaccharides could be applied to improve hydration in the cosmetic field. The purified polysaccharide was extracted and deproteinized with the CaCl [...] Read more.
Traditional pumpkin (Cucurbita moschata) and Japanese pumpkin (C. maxima) consist of natural polysaccharides. From a scientific basis, natural polysaccharides could be applied to improve hydration in the cosmetic field. The purified polysaccharide was extracted and deproteinized with the CaCl2 method. Japanese pumpkin showed the higher value of physicochemical properties including yield (12.96 ± 0.60%), total polysaccharide content (0.89 ± 0.04 mg/mL), swelling capacity (4.00 ± 0.00%), swelling index (1.04 ± 0.00%), solubility (126.67 ± 5.77%), viscosity (1.25 ± 0.00 cps), water capacity (0.93 ± 0.15 g/g) and oil absorption capacity (5.93 ± 0.06 g/g) than traditional pumpkin. Additionally, Japanese pumpkin (IC50 9.30 ± 0.58 µg/mL) provided higher antioxidant activity by DPPH assay than traditional pumpkin (IC50 9.98 ± 0.25 µg/mL). The evaluation of efficacy on skin hydration in fifteen Thai volunteers indicated that Japanese pumpkin showed non-skin irritation. An extract concentration of 0.05–0.1% showed a significantly increased effect in moisturizing ability according to concentration (p < 0.05). This result supported that it was safe and effective to use as a moisturizer for cosmetic products. Full article
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9 pages, 587 KiB  
Article
Complete Genome Sequence and Cosmetic Potential of Viridibacillus sp. JNUCC6 Isolated from Baengnokdam, the Summit Crater of Mt. Halla
by Min Nyeong Ko and Chang-Gu Hyun
Cosmetics 2022, 9(4), 73; https://doi.org/10.3390/cosmetics9040073 - 6 Jul 2022
Viewed by 2619
Abstract
Novel microbe-derived products are gaining increasing attention for their ability to modulate skin conditions. The use of microbial metabolites to improve skin health outcomes is of particular interest because growing evidence points to the importance of natural products without side effects on human [...] Read more.
Novel microbe-derived products are gaining increasing attention for their ability to modulate skin conditions. The use of microbial metabolites to improve skin health outcomes is of particular interest because growing evidence points to the importance of natural products without side effects on human health. This study aimed to sequence the genome of Viridibacillus sp. JNUCC6 isolated from Baengnokdam, the summit crater of Mt. Halla. We further investigated the potential use of its extract as a cosmetic ingredient in controlling melanogenesis and inflammation. The genome of this strain was sequenced using both Illumina Novaseq 6000 and third-generation sequencing technology (PacBio RSII) to obtain trustworthy assembly and annotation. Different concentrations of the Viridibacillus sp. JNUCC6 extract were tested for its anti-melanogenic and anti-inflammatory effects in α-melanocyte-stimulating hormone (α-MSH)-induced B16F10 melanoma and lipopolysaccharide (LPS)-activated RAW 264.7 cells, respectively. The whole genome sequence of the strain contained 4,526,142 bp with 35.61% GC content, one contig, and 4364 protein-coding sequences. Furthermore, antiSMASH analysis of the whole genome revealed three putative biosynthetic gene clusters that are responsible for the production of various secondary metabolites. Our study found that the Viridibacillus sp. JNUCC6 extract inhibited the α-MSH-induced melanin production and tyrosinase activity in B16F10 melanoma cells. In addition, it decreased the LPS-induced nitric oxide (NO) production caused by LPS stimulation in a concentration-dependent manner. Therefore, Viridibacillus sp. JNUCC6 has potential applications as an ingredient in skin-whitening and anti-inflammatory products and can be used in the cosmetic and medical industries. Full article
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11 pages, 1445 KiB  
Article
Cosmeceutical Potentials of Grammatophyllum speciosum Extracts: Anti-Inflammations and Anti-Collagenase Activities with Phytochemical Profile Analysis Using an Untargeted Metabolomics Approach
by Yodying Yingchutrakul, Wattanapong Sittisaree, Thanisorn Mahatnirunkul, Thitikorn Chomtong, Tatpong Tulyananda and Sucheewin Krobthong
Cosmetics 2021, 8(4), 116; https://doi.org/10.3390/cosmetics8040116 - 9 Dec 2021
Cited by 14 | Viewed by 4157
Abstract
Grammatophyllum speciosum is the largest orchid species and a well-known traditional medicinal plant. Due to skin aging, natural products that inhibit this process can attract the attention of consumers and scientists because radical-scavenging activity, collagenase inhibition, and inflammatory suppression are valuable in dermatological [...] Read more.
Grammatophyllum speciosum is the largest orchid species and a well-known traditional medicinal plant. Due to skin aging, natural products that inhibit this process can attract the attention of consumers and scientists because radical-scavenging activity, collagenase inhibition, and inflammatory suppression are valuable in dermatological applications. This study investigated the phytochemicals in G. speciosum leaves extracts that have cosmeceutical potentials, including radical-scavenging, anticollagenase, and anti-inflammatory abilities. G. speciosum leaves were extracted using water-based extraction methods. High-resolution mass spectrometry was used to identify the phytochemicals in the extracts. Fibroblast and keratinocyte cell cytotoxicity was determined. Antioxidant abilities were measured using DPPH and ABTS assays. The effect of the extracts on nitric oxide (NO) in macrophage cells was investigated. ELISA of the collagenase enzyme was determined. A total of 721 annotated metabolites were identified in the extracts. Vitexin and orientin were the most abundant metabolites. Cell viability was >80% in both cell lines when the extract concentration was <1 mg/mL. The IC50 values for DPPH and ABTS were 56 and 117 μg/mL, respectively. Furthermore, the extracts revealed that NO and collagenase activity were suppressed by 42% and 23%, respectively. The extracts can suppress ROS, inflammatory, and collagenase activities without causing fibroblast and keratinocyte cell death. Thus, this study provides information on metabolites in G. speciosum leaves, which is promising as cosmeceuticals or pharmaceuticals with anti-inflammatory and anti-collagenase activities. Full article
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