Skin Aging and Dermatosis

A special issue of Cosmetics (ISSN 2079-9284). This special issue belongs to the section "Cosmetic Dermatology".

Deadline for manuscript submissions: closed (26 February 2026) | Viewed by 1932

Special Issue Editors


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Guest Editor
Department of Cell Biology/Physiology and The Neuroscience Center, College of Life Sciences, Brigham Young University, Provo, UT 84602, USA
Interests: dermatology; menopause; estrogen hormone actions; natural products (phytochemical); factors that influence skin aging
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Dermatology Consulting Services, PLLC, High Point, NC 27262, USA
Interests: dermatology; skin aging; dermatosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, “Skin Aging and Dermatosis”, will explore a variety of topics in the field of dermatology.

Skin aging is natural, such as chronological and photo-aging, is largely unavoidable, but lifestyle factors can slow down or delay aging, extending longevity and improving dermal wellbeing. The most dominant hormonal influence on skin aging is estrogen (17β-estradiol); its gradual decline and eventual loss during menopause affects almost all organ systems, having a profound and overall negative impact of the quality of life of women.

Menopause hormone therapy (MHT) can reverse several skin aging parameters. However, the fear, confusion, and hesitancy of physicians to prescribe MHT to women even with menopausal symptoms (vasomotor, hot flashes, etc.) has led to a scientific re-evaluation of the benefits and risks of MHT, causing a resurgence of topical estrogen applications to combat skin aging and estrogen-deficient skin during menopause. Moreover, there are other active ingredients, such as vitamins C and E, hyaluronic acid, retinoids, niacinamide, and naturally derived products (phytochemicals), that are highly effective in combating skin aging.

Dermatosis is associated with skin aging, the most common conditions of which include dermatoyositis, erythema nodosum, pemphigus vulgaris, psoriasis, sclerodema, Sweet syndrome, systemic lupus erythematosus, and vitiligo. Dermatosis can be caused by a variety of factors, including infections, irritants, allergies, genetic factors, autoimmune issues, and even certain medical conditions or medications.

This Special Issue will present the current status of research and potential future innovations regarding skin aging and dermatosis, serving as a valuable resource for dermatologists and clinical, corporate, and personal care professionals.

You may choose our Joint Special Issue in Life.

Prof. Dr. Edwin Lephart
Dr. Zoe D. Draelos
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin aging
  • chronological dermal aging
  • photo-aging
  • hormone therapy
  • menopause
  • estrogen-deficient skin
  • dermatosis
  • skin conditions

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Published Papers (1 paper)

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Research

12 pages, 644 KB  
Article
Heat-Treated Strains of Lactiplantibacillus Plantarum Skinbac™ SB01 and Bifidobacterium animalis spp. Lactis Skinbac™ SB05 Visibly Fight Aging Signs Both In Vitro and In Vivo
by Giovanni Deusebio, Annalisa Visciglia, Angela Amoruso and Marco Pane
Cosmetics 2026, 13(2), 76; https://doi.org/10.3390/cosmetics13020076 - 20 Mar 2026
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Abstract
Background: The skin microbiome plays a crucial role in maintaining barrier function and preventing inflammaging. Heat-treated probiotics offer stability advantages for topical formulations while potentially maintaining bioactive properties. Objective: To evaluate the safety, molecular mechanisms, and clinical efficacy of heat-treated Lactiplantibacillus plantarum [...] Read more.
Background: The skin microbiome plays a crucial role in maintaining barrier function and preventing inflammaging. Heat-treated probiotics offer stability advantages for topical formulations while potentially maintaining bioactive properties. Objective: To evaluate the safety, molecular mechanisms, and clinical efficacy of heat-treated Lactiplantibacillus plantarum Skinbac™ SB01 and Bifidobacterium animalis spp. lactis Skinbac™ SB05 in reducing visible signs of skin aging. Methods: In vitro studies assessed cytotoxicity (MTT/LDH assays), Aquaporin-3 (AQP3) expression, and reactive oxygen species (ROS) production in Normal Human Epidermal Keratinocytes (NHEK). A 30-day open-label clinical study (n = 20 females, 18–70 years) evaluated three formulations (face cream, serum, and eye contour) using instrumental measurements of hydration, elasticity, density, and roughness parameters. Results: In vitro testing showed a significant increase in AQP3 expression (+22% ± 3%, p = 0.03) and a non-significant reduction in ROS levels (−33% ± 9%, p = 0.06) at 107 TFU/well, with no cytotoxicity observed. Clinical evaluation demonstrated statistically significant improvements: eye contour formulation achieved +10.5% deep skin hydration (p < 0.0001) and −11% average roughness (p < 0.0001); serum showed +28.7% immediate hydration (p < 0.0001); and face cream improved gross skin elasticity by +6.3% (p < 0.01). No adverse events were reported. An independent and methodologically distinct placebo-controlled study was included for contextual support and was not directly compared with the present trial; this study evaluated a related 1% postbiotic formulation and reported statistically significant improvements over placebo in roughness, wrinkle depth, hydration, and biomechanical parameters. Conclusions: This pilot study provides preliminary evidence that heat-treated L. plantarum SB01 and B. animalis spp. lactis SB05 formulations could safely improve skin hydration and reduce roughness parameters. While in vitro results show a significant increase in AQP3 expression and an exploratory (non-significant) reduction in ROS levels, larger controlled trials are warranted to confirm clinical efficacy. Full article
(This article belongs to the Special Issue Skin Aging and Dermatosis)
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