Cosmetic Applications of Cannabinoids

A special issue of Cosmetics (ISSN 2079-9284).

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 31030

Special Issue Editors


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Guest Editor
Department of Analytical Chemistry, University of Valencia, 46100-Burjassot, Valencia, Spain
Interests: development and application of analytical methods in analytical chemistry; cosmetic products
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
GICAPC Research Group, Departamento of Analytical Chemistry, University of Valencia, Burjassot, Valencia, Spain
Interests: analytical chemistry; sample preparation; extraction techniques; miniaturization; liquid chromatography; gas chromatography; mass spectrometry; quality control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Some evidence suggests that cannabinoids, particularly cannabidiol (commonly named CBD), provide interesting benefits for the skin. Thus, cannabinoids have recently emerged as a new trend in cosmetic product formulations, and this has led to a boom in cosmetics that include them in their composition. Cannabinoids can be obtained from the Cannabis sativa L. plant (phytocannabinoids) using different procedures or they can be produced synthetically in laboratories (synthetic cannabinoids).

The current legal situation related to the obtaining and production of raw materials as well as the elaboration and commercialization of cosmetic products containing cannabinoids is often considered a controversial situation, so it would be interesting to clarify upon this in addition to providing methods for analytical control.

This Special Issue calls for manuscripts related to cosmetic applications of cannabinoids in the market today, which contribute to providing scientific information on different topics such as skin benefits and efficacy studies, safety studies, regulatory aspects in different countries, methods of obtaining and producing raw materials, and chemical analysis of raw materials and finished cosmetic products containing cannabinoids.

Prof. Dr. Amparo Salvador Carreño
Dr. Juan Luis Benedé Veiga
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cosmetic applications of cannabinoids
  • benefits and efficacy
  • regulatory aspects and safety
  • methods for obtaining and producing raw materials
  • analytical methods for quality control

Published Papers (4 papers)

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Research

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13 pages, 2682 KiB  
Article
HPLC Method for Separation of Cannabidiol Hemp Seed Oil with Skin Lipids and Tandem HRMS Technology for Characterization of a Chemical Marker
by Yuxin Liu, Yu Wang, Zhigang Hao and Long Pan
Cosmetics 2021, 8(4), 108; https://doi.org/10.3390/cosmetics8040108 - 17 Nov 2021
Cited by 4 | Viewed by 4336
Abstract
Cannabidiol (CBD) hemp seed oil is a commercial raw material with antioxidant and anti-inflammatory benefits that has been formulated into body wash and skin care products. The biggest analytical challenge is how to simultaneously quantify CBD and hemp seed oil as they deposited [...] Read more.
Cannabidiol (CBD) hemp seed oil is a commercial raw material with antioxidant and anti-inflammatory benefits that has been formulated into body wash and skin care products. The biggest analytical challenge is how to simultaneously quantify CBD and hemp seed oil as they deposited on the skin surface. CBD is easily separated and quantified from skin surface extracts via a HPLC-mass spectrometry methodology. However, the structural skeleton of triacylglycerides (TAGs) in hemp seed oil is same as those from the skin surface sebum. The strong hydrophobicity with subtle structural difference challenges their separation. In this project, a new reverse phase HPLC-high resolution mass spectrometry methodology was developed with a strong mobile phase normal propanol. The separated hemp seed oil TAGs in the chromatogram were identified and characterized using data-dependent acquisition (DDA) technology. Based on the daughter ion characterization, the separated peak with an ammonium adduct at 890.7226 [M + NH4]+ was confirmed as the parent ion of glycerol with three omega-3 fatty acid chains. This is the first time TAG structure with direct HPLC-tandem mass spectrometry technology has been elucidated without a hydrolysis reaction. The confirmed TAG structure with an ammonium adduct at 890.7226 ± 0.0020 can be used as a representative chemical marker for the hemp seed oil quantification. Full article
(This article belongs to the Special Issue Cosmetic Applications of Cannabinoids)
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10 pages, 254 KiB  
Article
Risk Assessment of Over-the-Counter Cannabinoid-Based Cosmetics: Legal and Regulatory Issues Governing the Safety of Cannabinoid-Based Cosmetics in the UAE
by Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Baharudin Ibrahim, Mohamed Azmi Hassali and Sa’ed H. Zyoud
Cosmetics 2021, 8(3), 57; https://doi.org/10.3390/cosmetics8030057 - 23 Jun 2021
Cited by 6 | Viewed by 4032
Abstract
Purpose: The lack of scientific evidence of the safety and efficacy of over-the-counter topical cannabinoid-based cosmetics remains a concern. The current study attempted to assess the quality of cannabinoid-based cosmetic products available on the UAE market. In particular, the study attempted to [...] Read more.
Purpose: The lack of scientific evidence of the safety and efficacy of over-the-counter topical cannabinoid-based cosmetics remains a concern. The current study attempted to assess the quality of cannabinoid-based cosmetic products available on the UAE market. In particular, the study attempted to quantify the presence of undeclared tetrahydrocannabinol, specifically delta-9-tetrahydrocannabinol (THC) and delta-9-tetrahydrocannabinolic acid (THCA), in these products. Methods: A total of 18 cannabinoid-based cosmetics were collected and analysed in this study. GC-MS analysis was used to determine the presence of total undeclared tetrahydrocannabinol. Results: The estimate for the average tetrahydrocannabinol content was 0.011% with a 95% CI (0.004−0.019). Leave-on cosmetics products are more likely to contain total tetrahydrocannabinol compared to rinse-off cosmetics (p = 0.041). Although there was no statistically significant difference in the total tetrahydrocannabinol according to cosmetic category, there was a tendency towards higher tetrahydrocannabinol content in the hand care products, baby products, and body care preparations. Conclusion: The current study reveals the need for producers of cannabinoid-based cosmetic products to issue quality certificates for each batch produced to inform users of the tested levels of tetrahydrocannabinol. Full article
(This article belongs to the Special Issue Cosmetic Applications of Cannabinoids)
9 pages, 2941 KiB  
Article
A Rapid and Sensitive Method for the Determination of Cannabidiol in Cosmetic Products by Liquid Chromatography–Tandem Mass Spectrometry
by Lorenza Schettino, Marta Prieto, Juan L. Benedé, Alberto Chisvert and Amparo Salvador
Cosmetics 2021, 8(2), 30; https://doi.org/10.3390/cosmetics8020030 - 21 Apr 2021
Cited by 5 | Viewed by 4958
Abstract
Cannabidiol is a phytocannabinoid with proven pharmacological properties that is also used in the cosmetic industry for its sebostatic and antioxidant activities, being considered a new anti-aging ally. An analytical method is proposed for the determination of CBD in cosmetic products by liquid [...] Read more.
Cannabidiol is a phytocannabinoid with proven pharmacological properties that is also used in the cosmetic industry for its sebostatic and antioxidant activities, being considered a new anti-aging ally. An analytical method is proposed for the determination of CBD in cosmetic products by liquid chromatography with tandem mass spectrometry, after leaching the CBD from the cosmetic matrix with ethanol. Low instrumental limits of detection (0.22 ng mL−1) and quantification (0.74 ng mL−1) allow the determination of CBD at trace levels without needing preconcentration, whereas the wide linearity of the method allows the determination of CBD in more concentrated samples without high dilution. The method was successfully applied to the analysis of six cosmetic products and a raw material. The proposed method is suitable for the quality control of cosmetic products containing CBD, being able to quickly and easily determine this compound, ensuring that its concentration in the finished product is the desired one. Full article
(This article belongs to the Special Issue Cosmetic Applications of Cannabinoids)
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Review

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18 pages, 1398 KiB  
Review
Topical Use of Cannabis sativa L. Biochemicals
by Léonid Mnekin and Lionel Ripoll
Cosmetics 2021, 8(3), 85; https://doi.org/10.3390/cosmetics8030085 - 8 Sep 2021
Cited by 12 | Viewed by 15557
Abstract
Cannabis sativa L. plant is currently attracting increasing interest in cosmetics and dermatology. In this review, the biologically active compounds of hemp are discussed. Particularly the complex interactions of cannabinoids with the endocannabinoid system of the skin to treat various conditions (such as [...] Read more.
Cannabis sativa L. plant is currently attracting increasing interest in cosmetics and dermatology. In this review, the biologically active compounds of hemp are discussed. Particularly the complex interactions of cannabinoids with the endocannabinoid system of the skin to treat various conditions (such as acne, allergic contact dermatitis, melanoma, and psoriasis) with clinical data. Moreover, the properties of some cannabinoids make them candidates as cosmetic actives for certain skin types. Hemp seed oil and its minor bioactive compounds such as terpenes, flavonoids, carotenoids, and phytosterols are also discussed for their added value in cosmetic formulation. Full article
(This article belongs to the Special Issue Cosmetic Applications of Cannabinoids)
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