Wound Healing: Exploring Novel Biomaterials and Compounds in Light of Cellular and Molecular Mechanisms

Dear Colleagues,

Wound treatment still represents a significant medical problem with important economic implications. This applies to both acute and chronic wounds and is especially true for surgical wounds, primarily in orthopedic implant surgery, and for wounds in diabetics or the elderly. Indeed, in the conditions mentioned above, patients present with complex wounds where inflammation persists, healing is slow or never occurs, and where infection can pose a very heavy burden in terms of frequency, severity and irreducibility. Molecular knowledge is emerging and innovative strategies for the treatment of wounds are being developed that can help create a fruitful connection between experimental research and clinical application, according to the concept of translational medicine: from bench to bedside. In this context, discussing the complexity of cellular and molecular mechanisms of wound repair and how they can be modulated through the application of advanced strategies can enrich and update our knowledge. We need new molecules and new biomaterials, hopefully with beneficial characteristics: pro-regenerative, pro-reparative, anti-inflammatory, anti-infective. Even more desirable is that it is possible to identify new molecules and new materials, natural or synthetic, which simultaneously present a plurality of these beneficial characteristics. This special issue aims to provide an overview of the latest advances in the field of wound healing. It also aims to encourage the development and characterization of new molecules and biomaterials for their treatment.

Prof. Dr. Carla Renata Arciola
Guest Editor

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