Clinical Diagnosis and Treatment on Pulmonary Hypertension in Newborns and Children
A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Cardiology".
Deadline for manuscript submissions: closed (5 July 2022) | Viewed by 6274
Special Issue Editor
Interests: pediatric cardiology and pediatric pulmonology; investigation on pulmonary hypertension-associated heart failure
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pulmonary hypertension (PH) is pulmonary vascular disease defined as increased pulmonary artery pressure. Pathologically, pulmonary vascular remodeling occurs with varying severity, resulting in pressure overload in the right ventricle, right ventricular hypertrophy, and even mortality in some cases. Compared with adult patients, PH is characterized by complex heterogeneity in pediatric patients with congential heart disease, bronchopulmonary dysplasia, persisent pulmonary hypertension of newborn (PPHN), collagen disease, etc. The Nice PH classification does not completely characterize or individualize any subgroup of pediatric PH. This is in contrast to the Panama classification, in which prenatal and fetal origins of many pulmonary vascular diseases in neonates and children, perinatal pulmonary vascular maladaptation, prenatal and postnatal pulmonary vascular mal-development, and pulmonary vascular hypoplasia are included. Moreover, it is necessary to develop a more comprehensive algorithm in which multiple specific pediatric risk factors are determined. The critical goal of treatment should be to permit children with PAH to engage in normal activities without the need to self-limit. Beneficial data on diagnosis and targeted pharmacologic interventions are still in the preliminary stages, and large trials are warranted.
In this Special Issue, we invite you to submit interesting and up-to-date articles related to clinical diagnosis and treatment of pulmonary hypertension in newborns and children.
Prof. Dr. Zen-Kong Dai
Guest Editor
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Keywords
- pulmonary hypertension
- vascular remodeling
- premature
- congenital heart disease
- bronchopumonary dysplasia
- vasodilator
- endothelial dysfunction
- idiopathic pulmonary arterial hypertension
- congenital pulmonary abnormality
- pressure overload
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