Depression in Adolescents: Risk, Outcomes, and Intervention

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Mental Health".

Deadline for manuscript submissions: closed (15 November 2025) | Viewed by 1840

Special Issue Editor


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Guest Editor
Department of Community Health Systems, School of Nursing, University of California San Francisco, San Francisco, CA, USA
Interests: adolescent depression; gut–brain axis; gut microbiome; inflammation; probiotics and microbiome; targeted interventions; modifiable risk factors for depression; RCT; developmental psychopathology

Special Issue Information

Dear Colleagues,

Depression constitutes a major public health concern, with increasing prevalence from early to late adolescence. This condition can induce various challenges, including emotional, social, and physical health issues, and is a significant risk factor for suicide, the second leading cause of death among adolescents. As depression rates continue to rise, there is an urgent need for innovative strategies to identify risk factors, understand the underlying mechanisms of depression, and improve intervention efforts.

This Special Issue, “Depression in Adolescents: Risk, Outcomes, and Intervention”, welcomes original research and literature reviews that examine the diverse factors contributing to adolescent depression, including biological, psychological, developmental, and environmental influences (e.g., neurobiological changes, hormonal fluctuations, early trauma, peer relationships, socio-economic stress). We particularly seek studies that identify early warning signs, uncover mechanisms of risk, and propose innovative interventions that can help reduce the impact of depression among adolescents.

Contributions to this Special Issue should help identify key factors to consider in detecting depression early and guide the development of targeted interventions to more effectively address the growing incidence of depression in this vulnerable population.

Dr. Cherry Y. Leung
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adolescent depression
  • risk factors
  • interventions
  • biological risk factors
  • psychosocial risk factors
  • developmental

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Published Papers (1 paper)

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Review

21 pages, 413 KB  
Review
Obesity and Mental Health in Childhood and Adolescence: A Scoping Review of Recent Scientific Evidence
by María Morales-Suárez-Varela, Esther López-García, Isabel Peraita-Costa, José Manuel Pérez Puente, Agustín Llopis-Morales, Agustín Llopis-Gonzalez and Pilar Guallar-Castillón
Children 2025, 12(11), 1512; https://doi.org/10.3390/children12111512 - 7 Nov 2025
Cited by 1 | Viewed by 1530
Abstract
Background: Child and adolescent obesity represent an increasing public health concern due to their physical consequences and impact on mental health. Recent studies have shown a significant association between obesity and depressive disorders during childhood and adolescence. The primary aim of this review [...] Read more.
Background: Child and adolescent obesity represent an increasing public health concern due to their physical consequences and impact on mental health. Recent studies have shown a significant association between obesity and depressive disorders during childhood and adolescence. The primary aim of this review was to analyze scientific evidence on the relationship between obesity and mental health in children and adolescents, with a particular focus on depressive symptoms and the use of anthropometric indicators. Secondary objectives included identifying the most common assessment tools, describing treatment approaches, and exploring mediating factors. Methods: A scoping literature review was conducted. The PubMed, Cochrane, and SciELO databases were searched for records published between 2015 and 2025 that met the inclusion criteria. Results: The 24 studies identified revealed a significant association between obesity and depressive symptoms, although considerable methodological heterogeneity was noted. Some studies reported a direct relationship with BMI, whereas others emphasized mediating factors such as body image perception and self-esteem. Cognitive–behavioral interventions and integrated programs showed both physical and psychological benefits. Conclusions: The relationship between child and adolescent obesity and mental health is complex and multifactorial. Findings support the development of multidisciplinary interventions that simultaneously address nutritional and psychological aspects. Full article
(This article belongs to the Special Issue Depression in Adolescents: Risk, Outcomes, and Intervention)
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