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Children
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Advances in Pediatric Neurogenic Bladders: Diagnosis, Treatment, and Management Strategies
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Advances in Pediatric Neurogenic Bladders: Diagnosis, Treatment, and Management Strategies

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Nephrology & Urology".

Deadline for manuscript submissions: 10 September 2025 | Viewed by 320

Special Issue Editor

Dr. Agata Korzeniecka-Kozerska

E-Mail Website
Guest Editor
Associate Professor of Department of Pediatrics and Nephrology, Medical University of Białystok, 17 Waszyngtona Str., 15-274 Białystok, Poland
Interests: neurogenic bladder; micturition disturbances; kidney function

Special Issue Information

Dear Colleagues,

A neurogenic bladder is a specific bladder condition that can lead to chronic kidney disease and quite often progresses to end-stage renal disease. The effective management of children with neurogenic bladders requires a multidisciplinary approach, including an experienced nephrologist. Many of these patients require pharmacological correction, and most need clean intermittent catheterization (CIC). This pharmacological treatment is guided by urodynamic data. According to the principle of better prevention than treatment, it is necessary to identify early markers of damage to urinary bladders and/or kidney function, leading to a proper diagnosis and treatment plan to prevent kidney function and improve quality of life.

The goal of this Special Issue on “Advances in Pediatric Neurogenic Bladders: Diagnosis, Treatment, and Management Strategies” is to highlight recent advances in algorithms and their approach to pediatric neurogenic bladders, which could be used in data integration and enhancement, improving diagnostic accuracy, personalized treatment plans, monitoring, and early intervention.

Dr. Agata Korzeniecka-Kozerska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurogenic bladder
  • biomarkers
  • kidney function damage
  • kidney function
  • urodynamic investigations
  • dysfunctional voiding
  • clean intermittent catheterization

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Published Papers (1 paper)

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Research

8 pages, 195 KiB  
Article
Antioxidant Status in Children with Neurogenic Bladder
by Joanna Bagińska-Chyży and Agata Korzeniecka-Kozerska
Children 2025, 12(6), 668; https://doi.org/10.3390/children12060668 - 23 May 2025
Viewed by 224
Abstract
Background: Pediatric neurogenic bladder (NB), often resulting from myelomeningocele, impairs bladder function due to disrupted neural control and is worsened by urinary retention, recurrent urinary tract infections, the absence of voluntary voiding, and additional sequelae of myelomeningocele, such as motor impairments, delayed colonic [...] Read more.
Background: Pediatric neurogenic bladder (NB), often resulting from myelomeningocele, impairs bladder function due to disrupted neural control and is worsened by urinary retention, recurrent urinary tract infections, the absence of voluntary voiding, and additional sequelae of myelomeningocele, such as motor impairments, delayed colonic transit, and nutritional deficiencies. Oxidative stress arises from an imbalance between oxidant production and the body’s antioxidant defenses and is recognized as both a contributor to and a consequence of various pathological conditions. This study aims to assess the total antioxidant status (TAS) in NB patients, evaluate its impact on urinary antioxidants, and correlate the findings with the urodynamic parameters in NB patients compared to those in non-NB controls. Methods: This study included 29 patients with NB, who were compared with 57 non-NB individuals. The comparative analyses encompassed serum and urinary total antioxidant status normalized to creatinine (uTAS/creatinine) and renal function markers (creatinine, urea, uric acid, and the glomerular filtration rate [GFR]), as well as urodynamic findings. TAS was determined using the colorimetric ABTS method. Results: The patients with NB demonstrated a significantly lower serum TAS and elevated urinary TAS and uTAS/creatinine ratios in comparison to these values in the control group (p < 0.001). Furthermore, a positive correlation was observed between uTAS/creatinine and detrusor pressure at the maximum cystometric capacity, while a negative correlation was found between uTAS/creatinine and bladder wall compliance (r = 0.5, r = −0.68 respectively). Conclusions: The observed decrease in serum TAS and the increase in urinary TAS in NB may not only serve as evidence of an imbalance in antioxidant homeostasis but also suggest a potential contributory role to the deterioration of urodynamic function. Full article
(This article belongs to the Special Issue Advances in Pediatric Neurogenic Bladders: Diagnosis, Treatment, and Management Strategies)
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