The Pediatric Formulations: The Present and a Challenge for Future

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Drugs".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 393

Special Issue Editor


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Guest Editor
College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Room 661, Memphis, TN 38163, USA
Interests: pediatric formulations; enhancing drug solubility; enhancing drug stability; enhancing drug permeability; design of prodrugs
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Special Issue Information

Dear Colleagues,

In recent years, the Food and Drug Administration (FDA), the European Medicines Agency (EMA), and the National Institute of Health (NIH) have shown remarkable interest in the development of pediatric formulations. Despite all the incentives offered by the above governmental agencies, however, many therapeutic agents continue to lack pediatric-friendly drug delivery systems.

One of the major challenges that academic scientists have traditionally faced in this area is the lack of funding and support for this line of research, with most of the governmental funding being dedicated to the advancement of novel drug delivery systems, with little impact on the pediatric population. Many novel and targeted drug delivery systems have faced challenges regarding their translation into pediatric patients. Some of these limitations include the excipients’ toxicity and limited stability and shelf life, but the major challenge has been pursuing the most invasive drug delivery route (parenteral delivery). It is generally accepted that translational drug delivery systems are friendlier, easier to use, impact the safety and prosperity of children, and profoundly prolong their adherence to medication when designed properly. Due to the lack of funding in this area, however, very few academician scientists have attempted to advance this area of research.

This Special Issue of Children aims to highlight the importance of pediatric formulations and to provide scientists with a platform to publish their novel research in this area. 

This Special Issue welcomes the submission of original research and review articles that pertain to “The Pediatric Formulations: The Present and a Challenge for Future”.

We look forward to receiving your contributions.

Kind regards,

Dr. Hassan Almoazen
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric formulations
  • drug stability
  • drug solubility
  • drug permeability
  • prodrug design
  • sublingual absorption
  • oral absorption
  • transdermal delivery
  • pulmonary delivery
  • fast dissolving tablets
  • fast dissolving films
  • microneedles
  • oral niosomes

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Published Papers (1 paper)

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Research

12 pages, 1510 KiB  
Article
Improving Medication Safety Through Medication Reconciliation in Pediatric Neurology: Clinical Pharmacist Recommendations and Physician Uptake in a 13-Week Study
by Margherita Zennaro, Anna Trotter, Daniele Mengato, Laura Camuffo, Claudio Ancona, Irene Toldo, Maria Cecilia Giron, Maria Federica Pelizza, Margherita Nosadini, Giorgio Perilongo, Stefano Sartori and Francesca Venturini
Children 2025, 12(5), 625; https://doi.org/10.3390/children12050625 - 12 May 2025
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Abstract
Background/Objectives: Clinical pharmacy plays a crucial role in optimizing medication use, particularly in pediatric settings where drug therapy can be complex and understudied. This study aims to assess the impact of clinical pharmacists in the Pediatric Neurology and Neurophysiology Unit of the Padova [...] Read more.
Background/Objectives: Clinical pharmacy plays a crucial role in optimizing medication use, particularly in pediatric settings where drug therapy can be complex and understudied. This study aims to assess the impact of clinical pharmacists in the Pediatric Neurology and Neurophysiology Unit of the Padova University Hospital, focusing on physician acceptance of pharmacist suggestions and the types of advice most frequently followed. Methods: A retrospective observational study was conducted over 13 weeks to describe the implementation phase of clinical pharmacists’ involvement in medication reconciliation in this setting. The study consisted of three steps. The study utilized a cluster model to categorize pharmacist suggestions and to evaluate physician acceptance rates. Results: The study included 57 hospitalized pediatric patients (53% male) with a median age of 3 years (IQR: 1–10.25). A total of 138 recommendations were shared, with an overall acceptance rate of 42%. Medication errors accounted for the largest cluster of suggestions (45%), though only 32% were accepted. Among the most frequently shared categories of suggestions, pharmaceutical form optimization (A) and drug supply (E) exhibited higher acceptance rates by clinicians (64% and 42%, respectively). The acceptance rate increased over time, peaking at 100% during weeks 7 and 11, correlating positively with enhanced collaboration between pharmacists and clinicians (R2 = 0.59). Conclusions: This study highlights the importance of clinical pharmacists in pediatric care, particularly in improving medication management through targeted interventions. The findings suggest that integrating clinical pharmacists into multidisciplinary teams can enhance patient care quality by fostering collaboration and trust among healthcare professionals. Full article
(This article belongs to the Special Issue The Pediatric Formulations: The Present and a Challenge for Future)
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