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Children
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Virulence Factors, Antimicrobial Resistance and Genomics in Pediatric Infectious Diseases
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Virulence Factors, Antimicrobial Resistance and Genomics in Pediatric Infectious Diseases

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Infectious Diseases".

Deadline for manuscript submissions: closed (10 November 2024) | Viewed by 2123

Special Issue Editors

Dr. Elizabeth-Barbara Tatsi

E-Mail Website
Guest Editor
First Department of Pediatrics, Infectious Diseases and Chemotherapy Research Laboratory, Medical School, National and Kapodistrian University of Athens, “Aghia Sophia” Children’s Hospital, 11526 Athens, Greece
Interests: genomics; next generation sequencing; molecular microbiology; antimicrobial resistance; virulence factors; genotyping; pediatric infectious diseases
Dr. Athanasios G Michos

E-Mail Website
Guest Editor
First Department of Paediatrics, Infectious Diseases and Chemotherapy Research Laboratory, Medical School, National and Kapodistrian University of Athens, “Aghia Sophia” Children’s Hospital, 11527 Athens, Greece
Interests: pediatric infectious diseases; molecular microbiology; diagnostics; immunology and pathogenesis of infectious diseases; vaccines
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The utilization of genomic methodologies, such as multiplex PCR, targeted sequencing, and whole genome sequencing, advances our comprehension of the etiology and mechanisms underlying pediatric infectious diseases. These sophisticated techniques transcend the constraints of traditional microbiological methods, enabling the identification of unknown causative pathogens, pathogen genotyping, detection of antimicrobial resistance genes, and virulence factors. Virulence factors, including toxins, enzymes, or cell surface proteins, emerge as potential targets for therapeutic interventions or vaccine development. Molecular epidemiological surveillance of circulating pathogens enhances our understanding of disease pathophysiology and microbial evolution.

We invite researchers to submit papers for the upcoming special issue titled "Virulence Factors, Antimicrobial Resistance and Genomics in Pediatric Infectious Diseases". This interdisciplinary issue aims to explore the intricate interplay between virulence factors and antimicrobial resistance, shedding light on genomic characteristics and epidemiological surveillance of pediatric infectious diseases using molecular techniques. Authors are encouraged to offer critical analyses and perspectives on current challenges and future directions in this field, aiming to advance our understanding and inform strategies for diagnosis, treatment, and prevention.

Dr. Elizabeth-Barbara Tatsi
Dr. Athanasios G Michos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric infectious diseases
  • molecular microbiology
  • molecular epidemiology
  • sequencing
  • whole genome sequencing
  • genotyping
  • virulence factors
  • antimicrobial resistance

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Published Papers (1 paper)

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Review

26 pages, 572 KiB  
Review
Proteomic Signatures of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Narrative Review
by Maria-Myrto Dourdouna, Elizabeth-Barbara Tatsi, Vasiliki Syriopoulou and Athanasios Michos
Children 2024, 11(10), 1174; https://doi.org/10.3390/children11101174 - 26 Sep 2024
Cited by 2 | Viewed by 1727
Abstract
Background/Objectives: Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious complication of COVID-19. MIS-C has overlapping features with other pediatric inflammatory disorders including Kawasaki Disease (KD), Macrophage Activation Syndrome (MAS), Toxic Shock Syndrome and sepsis. The exact mechanisms responsible for the clinical overlap [...] Read more.
Background/Objectives: Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious complication of COVID-19. MIS-C has overlapping features with other pediatric inflammatory disorders including Kawasaki Disease (KD), Macrophage Activation Syndrome (MAS), Toxic Shock Syndrome and sepsis. The exact mechanisms responsible for the clinical overlap between MIS-C and these conditions remain unclear, and biomarkers that could distinguish MIS-C from its clinical mimics are lacking. This study aimed to provide an overview of how proteomic methods, like Mass Spectrometry (MS) and affinity-based proteomics, can offer a detailed understanding of pathophysiology and aid in the diagnosis and prognosis of MIS-C. Methods: A narrative review of relevant studies published up to July 2024 was conducted. Results: We identified 15 studies and summarized their key proteomic findings. These studies investigated the serum or plasma proteome of MIS-C patients using MS, Proximity Extension, or Aptamer-based assays. The studies associated the proteomic profile of MIS-C with laboratory and clinical parameters and/or compared it with that of other diseases including acute COVID-19, KD, MAS, pediatric rheumatic diseases, sepsis and myocarditis or pericarditis following COVID-19 mRNA immunization. Depending on the method and the control group, different proteins were increased or decreased in the MIS-C group. The limitations and challenges in MIS-C proteomic research are also discussed, and future research recommendations are provided. Conclusions: Although proteomics appear to be a promising approach for understanding the pathogenesis and uncovering candidate biomarkers in MIS-C, proteomic studies are still needed to recognize and validate biomarkers that could accurately discriminate MIS-C from its clinical mimics. Full article
(This article belongs to the Special Issue Virulence Factors, Antimicrobial Resistance and Genomics in Pediatric Infectious Diseases)
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