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Children
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Maternal–Fetal Health: Helping Children Grow
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Maternal–Fetal Health: Helping Children Grow

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Neonatology".

Deadline for manuscript submissions: closed (10 March 2025) | Viewed by 3796

Special Issue Editor

Dr. Ofer Markovitch

E-Mail Website
Guest Editor
Meir Medical Center, Kfar Saba, Israel
Interests: brachial plexopathy; cleft lip and palate; clubfoot; corpus callosum agenesis; endometritis; neonatal sepsis; placental insufficiency

Special Issue Information

Dear Colleagues,

Prenatal diagnosis has been a staple in the field of maternal–fetal medicine for many years. New tools for ultrasound diagnosis, new screening strategies with which to identify serious diseases such as pre-eclampsia, risk of premature birth, and fetal anomalies, and the implementation of various preventive measures are among the latest achievements aimed at safeguarding maternal health and reducing fetal and neonatal morbidity and mortality.

This Special Issue will highlight recent advances in maternal–fetal medicine, including new approaches to fetal genetics and prenatal diagnosis and screening. Special attention will be paid to topics such as placental insufficiency, fetal malformation, fetal dysplasia, and genetic abnormalities.

Original research articles, systematic evaluations, analyses, and case-based comments are welcome. I look forward to receiving your contributions.

Dr. Ofer Markovitch
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • corpus callosum agenesis
  • clubfoot
  • cleft lip and palate
  • placental insufficiency
  • prenatal diagnosis
  • prenatal ultrasound
  • polyhydramnion
  • olygohydramnion
  • fetal growth restriction
  • macrosomia
  • CMA abnormalities

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

11 pages, 1128 KiB  
Article
Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study
by Aikaterini Kyriakopoulou, Kyriakos Samikos, Aikaterini Kanavaki, Efthymia Alexopoulou, Maria Argyropoulou, Theodora Psaltopoulou, Christina Kanaka-Gantenbein, Argyrios Dinopoulos, Melpomene Giorgi, Anastasia Antoniadou, Iliani Filippa, Nikolaos Siafakas, Stylianos Serghiou and Vassiliki Papaevangelou
Children 2025, 12(2), 223; https://doi.org/10.3390/children12020223 - 12 Feb 2025
Viewed by 583
Abstract
Objective: To investigate the clinical characteristics associated with the presence of LSV at birth. Design: Prospective 1:1 case–control study. Setting: Two tertiary neonatal units in Athens, Greece. Patients: Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks [...] Read more.
Objective: To investigate the clinical characteristics associated with the presence of LSV at birth. Design: Prospective 1:1 case–control study. Setting: Two tertiary neonatal units in Athens, Greece. Patients: Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected. Main outcome measure: Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided p-values were computed using the likelihood ratio test. Results: This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV. Conclusions: This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV’s pathophysiological mechanisms. Full article
(This article belongs to the Special Issue Maternal–Fetal Health: Helping Children Grow)
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10 pages, 449 KiB  
Article
The Association of Prenatal Antibiotic Use with Attention Deficit and Autism Spectrum Disorders: A Nationwide Cohort Study
by Yu-Chun Lin, Ching-Heng Lin and Ming-Chih Lin
Children 2023, 10(7), 1128; https://doi.org/10.3390/children10071128 - 29 Jun 2023
Cited by 5 | Viewed by 2751
Abstract
(1) Background: Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are common cognitive and behavioral disorders. Antibiotics are widely used in pregnant women and their newborns. The objective of this study was to examine the potential association between prenatal exposure to [...] Read more.
(1) Background: Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are common cognitive and behavioral disorders. Antibiotics are widely used in pregnant women and their newborns. The objective of this study was to examine the potential association between prenatal exposure to antibiotics and the risk of ADHD and ASD in childhood from a nationwide perspective. (2) Methods: The Taiwan National Health Insurance Research Database (NHIRD) was used as the primary data source. This nationwide cohort study included only first-time pregnancies. A total of 906,942 infants were enrolled. All infants were followed up for at least 6 years. The Cox regression model was applied for covariate control. (3) Results: Prenatal exposure to antibiotics was found to significantly increase the cumulative incidence of ADHD while having only a borderline effect on the cumulative incidence of ASD. Exposure to antibiotics during any of the three different gestational age ranges significantly increased the cumulative risk. However, only exposure after 34 weeks of gestation had a significant impact on the occurrence of ASD. The study also revealed a dose-dependent effect on the occurrence of ADHD but no effect on the occurrence of ASD. (4) Conclusions: This study suggests that prenatal exposure to antibiotics may increase the risk of developing ADHD and ASD later in life. Full article
(This article belongs to the Special Issue Maternal–Fetal Health: Helping Children Grow)
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