Intensive Care Medicine in Children: Current Concepts and Future Perspetives Update

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Nursing".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 4703

Special Issue Editor


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Guest Editor
Department of Paediatric Anaesthesia and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic
Interests: simulation medicine; paediatric intensive care medicine; regional anaesthesia; obstetric anaesthesia; patient safety; airway management
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Special Issue Information

Dear Colleagues,

I would like to invite you to contribute to this MDPI Special Issue of Children: “Intensive Care Medicine in Children: Current Concepts and Future Perspectives”. The aim of this Special Issue is to highlight the actual trends in paediatric intensive care medicine and point out the possible controversies in view of the evidence-based medicine (EBM) approach. The articles for this Issue will be selected mainly according to their possible impact on the daily clinical practice in intensive care. The Issue will be thematically divided into the sections dedicated to:

  • Airway management, oxygen therapy, mechanical ventilation and weaning;
  • Sepsis in intensive care: identification, treatment, antibiotic therapy;
  • Monitoring in intensive care: state of the art;
  • Haemodynamic optimalisation: accessing the critically ill paediatric patient;
  • Supportive treatment in intensive care: DVT prophylaxis, nutrition, rehabilitation, muscle strength;
  • Invasive procedures in paediatric intensive care—intravenous lines, arterial lines, regional anaesthesia;
  • Sedation, analgesia, sleep and cognitive disorders (delirium): screening tools, recommendation for clinical practice and possible treatment options;
  • COVID-19 and PIMS-TS in paediatric intensive care—a quick approach for a better outcome;
  • High-fidelity simulation-based approach: paediatric intensive care training;
  • Intensive care nursing—specifics of paediatric intensive care;
  • End-of-life decision and palliative care in children (multidisciplinary approach).

Prof. Dr. Petr Stourac
Guest Editor

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Keywords

  • paediatric patient
  • intensive care
  • sepsis
  • shock
  • respiratory failure
  • PIMS-TS
  • COVID-19

Published Papers (2 papers)

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Research

9 pages, 1002 KiB  
Article
Association between Platelet Transfusion and Delirium in Critically Ill Children
by Matthew Nelligan, Marianne E. Nellis, Elizabeth A. Mauer, Linda M. Gerber and Chani Traube
Children 2023, 10(5), 825; https://doi.org/10.3390/children10050825 - 01 May 2023
Cited by 1 | Viewed by 1567
Abstract
Delirium is a frequent, serious, and preventable complication in critically ill children. Inflammation has been implicated as a mechanism for the development of delirium. Platelet transfusions may potentiate the body’s pro-inflammatory responses. We hypothesized that receipt of platelets would be associated with delirium [...] Read more.
Delirium is a frequent, serious, and preventable complication in critically ill children. Inflammation has been implicated as a mechanism for the development of delirium. Platelet transfusions may potentiate the body’s pro-inflammatory responses. We hypothesized that receipt of platelets would be associated with delirium development in a pediatric intensive care unit (PICU). We performed a single-center retrospective cohort analysis including children admitted to the PICU between 2014 and 2018 who were transfused platelets within the first 14 days of admission. Data obtained included severity of illness, level of respiratory support, exposure to medications and blood products, as well as daily cognitive status. To account for time-dependent confounding, a marginal structural model (MSM) was constructed to delineate the relationship between platelet transfusion and next-day delirium. MSM demonstrated a 75% increase in the development of next-day delirium after transfusion of platelets (aOR 1.75, 95% CI 1.03–2.97). For every 1 cc/kg of platelet transfused, odds of next-day delirium increased by 9% (odds ratio 1.09, 95% CI 1.03–1.51). We reported an independent association between platelet transfusion and next-day delirium/coma after accounting for time-dependent confounders, with a dose–response effect. Minimizing platelet transfusions as much as clinically feasible may decrease delirium risk in critically ill children. Full article
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15 pages, 630 KiB  
Article
COVID-19-Associated Paediatric Inflammatory Multisystem Syndrome (PIMS-TS) in Intensive Care: A Retrospective Cohort Trial (PIMS-TS INT)
by Tereza Musilová, Jakub Jonáš, Tomáš Gombala, Jan David, Filip Fencl, Eva Klabusayová, Jozef Klučka, Milan Kratochvíl, Pavla Havránková, Adéla Vrtková, Kateřina Slabá, Jana Tučková, Lukáš Homola, Petr Štourač and Tomáš Vymazal
Children 2023, 10(2), 348; https://doi.org/10.3390/children10020348 - 10 Feb 2023
Cited by 2 | Viewed by 2251
Abstract
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a new disease in children and adolescents that occurs after often asymptomatic or mild COVID-19. It can be manifested by different clinical symptomatology and varying severity of disease based on multisystemic inflammation. The [...] Read more.
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a new disease in children and adolescents that occurs after often asymptomatic or mild COVID-19. It can be manifested by different clinical symptomatology and varying severity of disease based on multisystemic inflammation. The aim of this retrospective cohort trial was to describe the initial clinical presentation, diagnostics, therapy and clinical outcome of paediatric patients with a diagnosis of PIMS-TS admitted to one of the 3 PICUs. All paediatric patients who were admitted to the hospital with a diagnosis of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) during the study period were enrolled in the study. A total of 180 patients were analysed. The most common symptoms upon admission were fever (81.6%, n = 147), rash (70.6%, n = 127), conjunctivitis (68.9%, n = 124) and abdominal pain (51.1%, n = 92). Acute respiratory failure occurred in 21.1% of patients (n = 38). Vasopressor support was used in 20.6% (n = 37) of cases. Overall, 96.7% of patients (n = 174) initially tested positive for SARS-CoV-2 IgG antibodies. Almost all patients received antibiotics during in-hospital stays. No patient died during the hospital stay or after 28 days of follow-up. Initial clinical presentation and organ system involvement of PIMS-TS including laboratory manifestations and treatment were identified in this trial. Early identification of PIMS-TS manifestation is essential for early treatment and proper management of patients. Full article
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