New Insights in Neonatal Resuscitation—2nd Edition

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Neonatology".

Deadline for manuscript submissions: 30 January 2026 | Viewed by 451

Special Issue Editor


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Guest Editor
Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, AB T5H 3V9, Canada
Interests: neonatal hypoxic ischemic encephalopathy; neonatal resuscitation; respiratory distress syndrome; newborns; infants; chronic lung disease; delivery room; resuscitation; chest compression; asphyxia; serious games; cognitive task analysis; eye-tracking
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Special Issue Information

Dear Colleagues,

Around 10% of newborns require assistance to initiate breathing at birth, and approximately 1% need advanced resuscitative interventions to restore cardiorespiratory function. Effective neonatal resuscitation relies on a series of critical, time-sensitive actions that are essential in improving survival outcomes.

This Special Issue will offer a thorough and up-to-date resource for researchers, clinicians, and healthcare professionals involved in neonatal care. It will serve as a platform to discuss and share the latest developments, innovative techniques, and emerging trends in neonatal resuscitation.

Our goal is to support the dissemination of knowledge to enhance the quality of care and outcomes for newborns in need of resuscitation. We welcome contributions addressing the following key areas: emerging techniques and technologies, clinical guidelines and protocols, quality improvement initiatives, multidisciplinary approaches, ethical considerations, global perspectives, long-term outcomes and follow-up, education and training innovations in preterm resuscitation, and challenges and future directions.

We invite submissions of original research, including randomized controlled trials, observational and cohort studies, animal studies, review articles, systematic reviews and meta-analyses, trial protocols, and survey-based studies.

Prof. Dr. Georg Schmölzer
Guest Editor

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • neonatal resuscitation
  • newborn
  • delivery room
  • oxygen
  • cord management
  • respiratory support

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Published Papers (1 paper)

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Research

11 pages, 4126 KB  
Article
Dose-Related Pharmacokinetic and Pharmacodynamic Effects of Intramuscular Epinephrine in Healthy Neonatal Piglets
by Marwa Ramsie, Po-Yin Cheung, Raza Hyderi, Shrieya Praveen, Tze-Fun Lee, Megan O'Reilly and Georg M. Schmölzer
Children 2025, 12(9), 1180; https://doi.org/10.3390/children12091180 - 4 Sep 2025
Viewed by 331
Abstract
Background: Epinephrine is currently the only vasopressor recommended during neonatal cardiopulmonary resuscitation (CPR). Rapid vasopressor administration is critical during CPR; however, establishing vascular access can take several minutes and requires extensive skills and/or training. The intramuscular (IM) route provides rapid drug administration and [...] Read more.
Background: Epinephrine is currently the only vasopressor recommended during neonatal cardiopulmonary resuscitation (CPR). Rapid vasopressor administration is critical during CPR; however, establishing vascular access can take several minutes and requires extensive skills and/or training. The intramuscular (IM) route provides rapid drug administration and does not require special skills, training, or equipment. We aimed to compare various doses of IM epinephrine to intravascular (IV) epinephrine in a healthy neonatal piglet model. Method: Fifteen newborn piglets (1–3 days of age) underwent anesthesia, intubation via a tracheostomy, and randomization to 0.02 mg/kg IM epinephrine, 0.1 mg/kg IM epinephrine, or 0.02 mg/kg IV epinephrine. Hemodynamic and cardiac function parameters were continuously recorded throughout the experiment. Blood was collected prior to drug administration and throughout the experiment for pharmacokinetic and pharmacodynamic analysis. Results: Dose-dependent changes in hemodynamic and cardiac function parameters were observed following IM epinephrine administration. Greater changes were observed with 0.1 mg/kg IM epinephrine, while there were little to no changes with 0.02 mg/kg IM epinephrine. Pharmacokinetic parameters were not different between 0.02 mg/kg IV epinephrine or 0.1 mg/kg IM epinephrine. Conclusions: IM epinephrine dose of 0.1 mg/kg was more effective in producing systemic hemodynamic and cardiac function changes compared to the lower IM dose 0.02 mg/kg. Full article
(This article belongs to the Special Issue New Insights in Neonatal Resuscitation—2nd Edition)
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