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Special Issue "Diversity in Sensing Applications of Porphyrin or Other Macrocyclic Compound-Based Materials"

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A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Applied Chemical Sensors".

Deadline for manuscript submissions: 20 November 2023 | Viewed by 8644

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Special Issue Editors

Dr. Eugenia Fagadar-Cosma

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Guest Editor

Institute of Chemistry “Coriolan Dragulescu” of Romanian Academy, Mihai Viteazul Ave., No. 24, 300223 Timisoara, Romania
Interests: porphyrins; metalloporphyrins; porphyrin-based hybrid materials; AuNPs, AgNPs, PtNPs; chemical and electrochemical sensors; detection of analytes with medical relevance
Special Issues, Collections and Topics in MDPI journals

Dr. Dana Vlascici

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Guest Editor

Faculty of Chemistry, Biology, Geography, West University of Timisoara, 4 V. Parvan Ave, 300223 Timisoara, Romania
Interests: ion-selective electrode; potentiometry; analytes with medical relevance; heavy metal ions; PVC membrane; pharmaceuticals

Special Issue Information

Dear Colleagues,

Porphyrin derivatives are versatile structures highly recognized for their capacity to distort from their planar geometry and to act as building blocks for a large variety of supramolecular architectures realized through noncovalent interactions. Moreover, functionalized porphyrins possess the desired chemical, optical, electronic and morphological properties that recommend them for use in the formulation of sensors and biosensors.

This Special Issue focuses on both bare porphyrins, heteroatom-containing porphyrin dimeric structures, porphyrin-based metal–organic frameworks and on other porphyrin-based materials designed to enhance the envisaged properties of porphyrins through synergistically added effects as a result of their interaction with other porphyrin molecules, noble metal nanoparticles or following their incorporation into polymers or organic or inorganic (zeolites or silica) matrices.

Greater consideration will be given to the obtainment and characterization of sensitive porphyrin-based materials and other macrocyclic compounds (crown ethers, calixarenes, cyclodextrins, cucurbiturils and cavitands) no matter if they belong to hybrid or composite materials, to the selection criteria of the best materials, construction details of sensors and biomedical nanodevice preparations and understanding types of interactions with analytes up to the establishment of detection mechanisms.

Due to their performance as amazing host compounds for the selective and sensitive detection of various chemical species, macrocyclic compounds are capable of forming coordination complexes with a large variety of metal ions, potential hazardous biomaterials, amino acids, neurotransmitters, vitamins, pharmaceuticals, relevant compounds for human health monitoring (amino acids, glucose, uric acid, iodide, peroxide species, antibodies, nucleic acids, DNA, peptides, etc.) and even gases.

The main aim of this Special Issue is to envisage the progress in biomedicine and monitor human health parameters by using macrocyclic compound derivatives as receptors or signaling molecules. The guest editors invite both original articles and reviews covering the field of chemical, electrochemical, optical and resistive sensor devices.

Dr. Eugenia Fagadar-Cosma
Dr. Dana Vlascici
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

porphyrins
other macrocyclic compounds (crown ethers, calixarenes and cyclodextrins)
porphyrin or macrocyclic compound-based materials
optical chemical sensors
fluorescence sensors
ion-selective electrodes
electrochemical sensors
screen-printed microelectrodes
detection of analytes with biomedical relevance
hazardous chemicals
metal ion detection
amino acids detection
pharmaceuticals detection
detection of gases

Published Papers (6 papers)

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Research

Open AccessArticle

Dilute-and-Shoot-Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry for Pteridine Profiling in Human Urine and Its Association with Different Pathologies

Claudia Giménez-Campillo

Marta Pastor-Belda

Natalia Arroyo-Manzanares

Natalia Campillo

Blanca del Val Oliver

José Zarauz-García

Luis Sáenz

and

Pilar Viñas

Chemosensors 2023, 11(6), 324; https://doi.org/10.3390/chemosensors11060324 - 01 Jun 2023

Viewed by 802

Abstract

Pteridines are a group of compounds synthesised by many living organisms that are involved in the metabolism of many cofactors and vitamins. Their concentration in biological fluids may be altered by various pathologies such as cancer or inflammatory bowel disease, urine being the main route of excretion. In this study, three lumazines and ten pterins were analysed in their native oxidation state using high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Their high concentration in urine samples and their good ionisation behaviour allow the use of the dilute-and-shoot method by simple filtration of the urine prior to chromatographic analysis. The final method offers excellent linearity, sensitivity and precision parameters, and a total of 135 urine samples were analysed from patients with some relevant information such as faecal calprotectin (FCP) levels, common diseases such as diabetes, hypertension and dyslipidaemia and immunological diseases such as inflammatory bowel disease (IBD). The pteridine profile was related to FCP levels without showing any correlation. In addition, pteridine levels were compared between healthy subjects and IBD, diabetic, hypertensive and dyslipidaemic patients, and significant differences were found between the two groups for some of the pteridines. Full article

(This article belongs to the Special Issue Diversity in Sensing Applications of Porphyrin or Other Macrocyclic Compound-Based Materials)

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Open AccessArticle

Ion Mobility Spectrometry for the Metabolomic Study of Inflammatory Bowel Disease Using the Volatile Organic Compounds Profile in Human Serum and Urine

María García-Nicolás

María Carmen Pérez-Álvarez

Fuensanta Abellán-Alfocea

Natalia Arroyo-Manzanares

Natalia Campillo

Blanca del Val-Oliver

Enrique Jiménez-Santos

José Zarauz-García

Luis Sáenz

and

Pilar Viñas

Chemosensors 2023, 11(2), 139; https://doi.org/10.3390/chemosensors11020139 - 14 Feb 2023

Viewed by 971

Abstract

Inflammatory bowel disease (IBD) is an immune-mediated disease characterized by chronic mucosal inflammation of the digestive tract. The IBD diagnosis is currently based on the results of imaging, clinical, and histopathological tests. The gold standard diagnostic method is endoscopy, an invasive imaging technique that requires patient sedation and prior bowel preparation and is expensive. In the present work, monitoring the volatile compound fingerprint of serum and urine by headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS) is presented as a rapid and reliable diagnostic complementary test for patients with IBD. The analytical method was optimized and applied for the analysis of serum (118) and urine (123) samples from patients with IBD (in remission and active phase of the disease) and healthy volunteers without IBD. Orthogonal partial least square discriminant analysis was performed using all the integrated markers present in the topographic maps of each sample type, allowing the differentiation between healthy IBD volunteers and IBD patients and between IBD status (remission or active). The individual study of markers allowed the identification and quantification of twelve and six compounds in urine and serum samples, respectively. This information was further used to perform a one-way analysis of variance to compare the different categories. Full article

(This article belongs to the Special Issue Diversity in Sensing Applications of Porphyrin or Other Macrocyclic Compound-Based Materials)

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Open AccessArticle

Asymmetric Pt(II)-Porphyrin Incorporated in a PVC Ion-Selective Membrane for the Potentiometric Detection of Citrate

and

Eugenia Fagadar-Cosma

Chemosensors 2023, 11(2), 108; https://doi.org/10.3390/chemosensors11020108 - 02 Feb 2023

Viewed by 813

Abstract

A new sensing material, Pt(II)-5-(4-carboxyphenyl)-10,15,20-tris(4-phenoxyphenyl)-porphyrin (Pt(II)-COOH-TPOPP), was synthesized and characterized. Polymeric membranes containing the porphyrin and three different plasticizers were used as an electroactive material for a new anion-selective sensor. The best composition of the membrane was the one plasticized with dioctylsebacate (DOS), the obtained sensor being citrate-selective in a linear range of 5 × 10⁻⁷–1 × 10⁻¹ M citrate. The slope was Nernstian (19.73 mV/decade) with good selectivity towards a number of interfering anions and a lifetime of five weeks. Full article

(This article belongs to the Special Issue Diversity in Sensing Applications of Porphyrin or Other Macrocyclic Compound-Based Materials)

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Figure 1

Open AccessCommunication

Ninhydrin Loaded Microcapsules for Detection of Natural Free Amino Acid

and

Chemosensors 2023, 11(1), 49; https://doi.org/10.3390/chemosensors11010049 - 05 Jan 2023

Cited by 1 | Viewed by 3207

Abstract

Natural free amino acids present in plant extracts or tea infusions provide a unique flavor and potential effect on anxiety and blood pressure reduction. Accordingly, quantifying free amino acids in foods has been of interest to food science and analytical research fields. The ninhydrin solution-based assay is a colorimetric method based on the formation and detection of Ruhemann’s purple complex. Media-based colorimetric detection requires specialized facilities and personnel; moreover, it can suffer from the interference of the analyte color. In this study, we developed ninhydrin-loaded microcapsules and a simple free amino acids detection procedure, by simply dipping the microcapsules into the analyte solution for 3 min. Among the five tested natural free amino acids, theanine exhibited the highest colorimetric response to microcapsule-based detection, with a limit of detection of 0.826 mM. Full article

(This article belongs to the Special Issue Diversity in Sensing Applications of Porphyrin or Other Macrocyclic Compound-Based Materials)

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Figure 1

Open AccessArticle

Simple, Accurate and Multianalyte Determination of Thirteen Active Pharmaceutical Ingredients in Polypills by HPLC-DAD

Barbara Żuromska-Witek

and

Chemosensors 2023, 11(1), 25; https://doi.org/10.3390/chemosensors11010025 - 28 Dec 2022

Cited by 2 | Viewed by 1304

Abstract

A new universal HPLC-DAD method has been developed for the separation and simultaneous determination of thirteen active pharmaceutical ingredients (APIs): ramipril, lisinopril, enalapril; atenolol, metoprolol; losartan, candesartan; rosuvastatin, atorvastatin, simvastatin; amlodipine; hydrochlorothiazide, acetylsalicylic acid in polypills used in the treatment of hypertension. The chromatographic analysis of the APIs was performed on an ACE-5 C18-PFP column (250 mm × 4.6 mm, 5 μm) with 0.01 M phosphate buffer (pH = 2.50) and acetonitrile in gradient elution as the mobile phase at a flow rate 1.0 mL min⁻¹. UV detection was performed at 230 nm. The analysis time was 35 min. The elaborated method meets the acceptance criteria for specificity, linearity, sensitivity, accuracy, and precision for all examined substances. The linearity range was observed in a wide concentration range, whereas the determination coefficients (R²) for the linear model were greater than 0.990. The sensitivity of the method was good with the LOD and LOQ values ranged from 0.0009 to 0.0923 mg mL⁻¹ and from 0.0027 to 0.2794 mg mL⁻¹, respectively. The proposed method showed good precision with RSD less than 1.91% and the accuracy expressed as percent recovery was from 95.20% to 104.62%. The proposed HPLC-DAD method was successfully applied to determine APIs in prepared model mixtures corresponding to the commercially available polypill tablets. The obtained results of the measured contents were with good accuracy (95.84–103.92%) and high precision (RSD < 0.95%) indicating the applicability of the proposed method for the simultaneous determination of the polypill components. Therefore, the method can be an effective tool in the quality control of polypills. Full article

(This article belongs to the Special Issue Diversity in Sensing Applications of Porphyrin or Other Macrocyclic Compound-Based Materials)

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Open AccessArticle

Porphyrin Hetero-Trimer Involving a Hydrophilic and a Hydrophobic Structure with Application in the Fluorescent Detection of Toluidine Blue

and

Eugenia Fagadar-Cosma

Chemosensors 2022, 10(11), 481; https://doi.org/10.3390/chemosensors10110481 - 15 Nov 2022

Viewed by 1011

Abstract

The combination of a metallated porphyrin, Pt(II)-5,10,15,20-tetrakis-(4-allyloxyphenyl)-porphyrin (Pt-allyloxyPP), and a water-soluble porphyrin, 5,10,15,20-tetrakis(4-sulfonatophenyl)-porphyrin (TSPP), leads to the formation of a porphyrin hetero-trimer. The hetero-trimer, consisting of two TSPP molecules linked via oxygen atoms axially to the platinum atom in the Pt-allyloxyPP molecule, was characterized by UV–Vis, FT-IR, fluorescence, and ¹H-NMR spectroscopy, and the proposed structure was confirmed. The new porphyrin hetero-trimer offers both the advantage of enhanced fluorescence and the presence of multiple sites for the detection of toluidine blue, due to its high affinity for acidic binding sites. This work brings attention to the purposely designed fluorescent sensor for toluidine blue, in the biologically relevant concentration domain of 1.9 × 10⁻⁶–6.39 × 10⁻⁵ M, with a very good accuracy. Full article

(This article belongs to the Special Issue Diversity in Sensing Applications of Porphyrin or Other Macrocyclic Compound-Based Materials)

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