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Chemosensors
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(Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers
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(Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers

A special issue of Chemosensors (ISSN 2227-9040).

Deadline for manuscript submissions: 31 December 2026 | Viewed by 5334

Special Issue Editors

Prof. Dr. Gaowa Xing

E-Mail Website
Guest Editor
Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants of Fujian Province, College of Environmental & Biological Engineering, Putian University, Putian 351100, China
Interests: microfluidic technology; microfluidic biosensors; miniaturization of analytical instruments; environmental and food safety analysis; organ on a chip
Special Issues, Collections and Topics in MDPI journals
Dr. Zengnan Wu

E-Mail Website
Guest Editor
College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China
Interests: microfluidics; analytical chemistry; organ on a chip; hydrogel materials; multiplexed detection

Special Issue Information

Dear Colleagues,

Since its launch, Chemosensors has been committed to advancing innovative sensing technologies across chemistry, biology, medicine, and environmental sciences. To further promote the visibility of early-career researchers, the journal has established the Early Career Editorial Board and initiated this Special Issue dedicated to showcasing the most recent achievements of young scientists.

This Special Issue welcomes contributions that reflect the diversity and vitality of the sensing field, including but not limited to food safety and quality analysis, biomedical and clinical diagnostics, environmental monitoring, novel analytical methodologies, functional materials for sensing, micro/nano-scale devices, point-of-care testing, and miniaturized or wearable instruments. We will also focus on the following:

  • Hybrid sensing systems for simultaneous detection of multiple food contaminants or biomarkers;
  • Functional materials and hydrogel-based micro/nanoplatforms for biological analysis;
  • Microfluidic and organ-on-chip technologies bridging food science and biomedical research;
  • Integrated analytical devices for portable, high-throughput, or point-of-care applications;
  • Cross-disciplinary strategies uniting food analysis and biomedical diagnostics through advanced data processing, AI, or imaging.

Prof. Dr. Gaowa Xing
Dr. Zengnan Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensor
  • food chemistry
  • environmental monitoring
  • artificial intelligence for sensing
  • cell analysis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (7 papers)

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Research

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15 pages, 5740 KB  
Article
A Real-Time Centrifugal Microfluidic Chip with Dual-Valving Strategy for Multiplexed PCR Detection at Point-of-Care Testing
by Yize Zhang, Youhong Zeng, Lingxuan Liu, Lei Wang, Hao Chen, Yatan Yuan, Yingying Ding, Guijun Miao, Lulu Zhang and Xianbo Qiu
Chemosensors 2026, 14(5), 118; https://doi.org/10.3390/chemosensors14050118 - 15 May 2026
Viewed by 279
Abstract
Different from isothermal amplification, for polymerase chain reaction (PCR), highly reliable valving for PCR chamber, significantly shortened thermal cycling time, and concise multiplexed detection are always challenges for microfluidic-based devices. Here, we present a real-time, centrifugal, plastic microfluidic chip for multiplexed PCR detection [...] Read more.
Different from isothermal amplification, for polymerase chain reaction (PCR), highly reliable valving for PCR chamber, significantly shortened thermal cycling time, and concise multiplexed detection are always challenges for microfluidic-based devices. Here, we present a real-time, centrifugal, plastic microfluidic chip for multiplexed PCR detection specifically based on the mechanism of cooperating valving. To achieve consistent amplification, a concise dual-valving strategy was developed. Instantly melted wax is centrifuged and completely filled into the narrow channel and hole to act as the compact wax valve. Meanwhile, an elastic and sticky membrane is depressed to seal the hole to act as the membrane valve. The wax valve is protected by the membrane valve from being damaged by both mechanical deformation and thermal corroding caused by the hot vapor with high pressure from the PCR chamber. A double-sided heating strategy is adopted to reduce the thermal cycling time; meanwhile, a balanced mechanism is used to achieve real-time amplification by rotating the centrifugal chip between the heating and detection positions in turn. As a proof-of-concept, the performance of the centrifugal chip with four parallel units is demonstrated by successfully detecting purified DNA templates or the extracted DNA templates from cells as well within 20 min. Full article
(This article belongs to the Special Issue (Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers)
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15 pages, 1868 KB  
Article
A COF-Based Turn-On Fluorescent Sensor for Rapid Visual Detection of Histamine in Food Spoilage
by Zixian Wu, Hui Zhou and You Zhou
Chemosensors 2026, 14(5), 104; https://doi.org/10.3390/chemosensors14050104 - 1 May 2026
Viewed by 346
Abstract
Unsafe food poses a significant threat to global public health and the economy, making the early detection of food spoilage an ongoing and critical imperative. Herein, we report the design of a straightforward and highly effective fluorescence sensor for monitoring histamine (HI), a [...] Read more.
Unsafe food poses a significant threat to global public health and the economy, making the early detection of food spoilage an ongoing and critical imperative. Herein, we report the design of a straightforward and highly effective fluorescence sensor for monitoring histamine (HI), a key biomarker of food deterioration, utilizing the direct interaction between the analyte and the sensor. We demonstrate that the inherently weak luminescent covalent organic framework (COF), TpPa-1, functions as a highly responsive “turn-on” luminescent switch in the presence of HI. Upon interaction with HI, the luminescence of TpPa-1 is significantly enhanced; this phenomenon is attributed to the generation of anionic N− species via the deprotonation of the N−H unit, which effectively suppresses the electron transfer pathway from the nitrogen lone pair to the COF backbone. The TpPa-1 sensor exhibits excellent sensitivity and reproducibility for HI detection. Furthermore, we developed a reusable, fluorescent COF-based film that displays a distinct, naked-eye visible color transition from red to yellow-green upon exposure to histamine, establishing a robust platform for rapid, and preliminary food quality assessment. This work presents a novel, COF-based strategy for HI detection, offering substantial significance for public health and food safety monitoring. Full article
(This article belongs to the Special Issue (Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers)
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15 pages, 9543 KB  
Article
A Novel Electrochemiluminescent Biosensor Based on Nitrogen-Doped Graphyne for Ultrasensitive Kanamycin Residue Detection in Milk and Honey Samples
by Yuxuan Liu, Tianzeng Huang, Yang Chen, Gaowa Xing, Hongmei Cao and Daixin Ye
Chemosensors 2026, 14(3), 76; https://doi.org/10.3390/chemosensors14030076 - 23 Mar 2026
Viewed by 616
Abstract
A novel sensitive and selective electrochemiluminescence (ECL) sensor using nitrogen-doped graphyne as the platform was proposed for kanamycin (KAN) detection. First, nitrogen-doped graphyne nanomaterial (1N-GY) with high conductivity was synthesized using a high-energy ball milling method. Compared with ordinary graphyne, the addition of [...] Read more.
A novel sensitive and selective electrochemiluminescence (ECL) sensor using nitrogen-doped graphyne as the platform was proposed for kanamycin (KAN) detection. First, nitrogen-doped graphyne nanomaterial (1N-GY) with high conductivity was synthesized using a high-energy ball milling method. Compared with ordinary graphyne, the addition of nitrogen atoms can improve the conductivity of the material and reduce the electronic migration energy barrier. Then it was used as a substrate material of the ECL sensor, not only increasing the conductivity of the biosensor but also improving the sensitivity of the ECL sensor by providing more immobilization space for the luminescent probe of Nafion-coated mesoporous silica adsorbed Ru(bpy)32+ (mSiO2@Nafion@Ru(bpy)32+). On this basis, mSiO2@Nafion@Ru(bpy)32+ functionalized DNA probes were used as luminescent and capture probes to specifically recognize different concentrations of KAN to produce ECL signals. Under optimal conditions, the proposed ECL sensor exhibited good linearity (10−12–10−6 M KAN) and a low detection limit of 1.08 pM. The prepared biosensor with good stability and selectivity successfully detected KAN in honey and milk samples, with spiked recovery rates ranging from 98% to 111.79%. This method not only expands the application of 1N-GY as a novel graphitic material in ECL biosensors but also provides an effective way to check antibiotics in dairy products. Full article
(This article belongs to the Special Issue (Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers)
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12 pages, 809 KB  
Article
Escherichia coli Optoelectronic Sensors for In Situ Monitoring of Selected Materials Across Water Supply Systems
by Yonatan Uziel, Natan Orlov, Loay Atamneh, Offer Schwartsglass, Shimshon Belkin and Aharon J. Agranat
Chemosensors 2026, 14(3), 62; https://doi.org/10.3390/chemosensors14030062 - 5 Mar 2026
Viewed by 793
Abstract
Chemical monitoring of pollutants and hazardous materials in water supply systems traditionally depends on centralized laboratories, advanced instrumentation, and trained personnel, limiting accessibility and preventing real-time, on-site analysis. This work presents an alternative cost-effective, field-deployable approach that uses genetically engineered bioluminescent bioreporters, encapsulated [...] Read more.
Chemical monitoring of pollutants and hazardous materials in water supply systems traditionally depends on centralized laboratories, advanced instrumentation, and trained personnel, limiting accessibility and preventing real-time, on-site analysis. This work presents an alternative cost-effective, field-deployable approach that uses genetically engineered bioluminescent bioreporters, encapsulated in self-sufficient alginate capsules and integrated with an optoelectronic detection circuit, to detect and quantify target materials in water. We have developed a scalable single-channel prototype featuring four sensing tracks—two for sample measurement, one for clean water, and one for a standard reference solution. The latter employs the standard ratio (SR) method to ensure robust quantification, compensating for batch variability and environmental effects. System characterization showed high uniformity across tracks. Validation with nalidixic acid (NA) demonstrated reliable quantitative performance, with a blind test estimation of 5.6 mg/L for a true concentration of 5 mg/L, well within the calibration error range. Additional sensitivity testing confirmed detection of mitomycin C (MMC) at concentrations as low as 50 µg/L. Overall, the results highlight the potential of bacterial chemical sensing as a practical and scalable tool for real-time, in situ water quality monitoring networks. Full article
(This article belongs to the Special Issue (Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers)
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18 pages, 7537 KB  
Article
Electrochemical Sensor Based on a Fe3O4 and Graphene Composite for the Detection of Myristicin
by Dewi Murniati, Deden Saprudin, Irmanida Batubara, Budi Riza Putra and Utami Dyah Syafitri
Chemosensors 2026, 14(2), 36; https://doi.org/10.3390/chemosensors14020036 - 2 Feb 2026
Cited by 1 | Viewed by 1227
Abstract
This study aims to develop an electrochemical sensor based on a glassy carbon electrode (GCE) modified with Fe3O4 and graphene for the detection of myristicin as a characteristic compound in nutmeg plants. Electrode modification materials were prepared from a combination [...] Read more.
This study aims to develop an electrochemical sensor based on a glassy carbon electrode (GCE) modified with Fe3O4 and graphene for the detection of myristicin as a characteristic compound in nutmeg plants. Electrode modification materials were prepared from a combination of graphene and magnetite, synthesized via a hydrothermal method, and further characterized using X-ray diffraction (XRD), scanning electron microscope–energy dispersive spectroscopy (SEM-EDS), and transmission electron microscopy (TEM). The two modifying materials were then optimized, and the optimum conditions were obtained at a w/w ratio of 1:2, which was applied to the GCE surface using the drop-casting technique. The electrochemical performance of the Fe3O4/graphene-modified electrode was evaluated under optimum experimental conditions using a Britton–Robinson buffer solution at pH 5. The scan-rate analysis of the electrode to evaluate its electrochemical performance showed an increase in surface area from 0.101 cm2 for the bare GCE to 0.534 cm2 for the GCE/Fe3O4–graphene. Electroanalytical performance was evaluated using differential pulse voltammetry (DPV), which showed a linear response over the concentration range of 1–100 µM, with a limit of detection of 0.19 µM and a limit of quantitation of 0.58 µM. The developed electrode was applied successfully to detect myristicin in nutmeg seed extract samples, and its calculated concentrations were not significantly different from those obtained with the GC-MS method. These results suggest that the developed sensor may have further potential as an alternative detection tool for characterizing electroactive compounds in nutmeg plants. Full article
(This article belongs to the Special Issue (Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers)
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18 pages, 2206 KB  
Article
Efficiently Monitoring Trace Nitrophenol Pollutants in Water Through the Dispersive Solid-Phase Extraction Based on Porous Organic Polymer-Modified Cellulose Nanofiber Membrane
by Xiaoyu He, Wangcheng Lan, Yuancai Lv, Xiaojing Li and Chen Tian
Chemosensors 2026, 14(2), 31; https://doi.org/10.3390/chemosensors14020031 - 29 Jan 2026
Viewed by 703
Abstract
Monitoring trace nitrophenol pollutants in water has garnered considerable attention. A porous organic polymer-modified cellulose nanofiber membrane (COP-99@DCA) was fabricated via in situ growth of a porous organic polymer on an electrospun cellulose nanofiber membrane. The resulting brown COP-99@DCA composite possessed abundant functional [...] Read more.
Monitoring trace nitrophenol pollutants in water has garnered considerable attention. A porous organic polymer-modified cellulose nanofiber membrane (COP-99@DCA) was fabricated via in situ growth of a porous organic polymer on an electrospun cellulose nanofiber membrane. The resulting brown COP-99@DCA composite possessed abundant functional groups, including C-F, C-O, and hydroxyl groups, and exhibited excellent thermal and chemical stability. Furthermore, when employed as a sorbent in dispersive solid-phase microextraction (d-SPME), COP-99@DCA efficiently enriched trace nitrophenols in water. Under optimal enrichment and desorption conditions, the enrichment efficiencies for five nitrophenol congeners ranged from 97.24% to 102.46%. Mechanistic investigations revealed that the efficient enrichment of trace nitrophenols by COP-99@DCA was primarily governed by hydrogen bonding, π-π stacking, and hydrophobic interactions. Coupled with solid-phase extraction (SPE) pre-treatment, high-performance liquid chromatography (HPLC) enabled the sensitive detection of trace nitrophenols. The established calibration curves exhibited favorable linearity, with low limits of quantitation (LOQs) ranging from 0.5 to 1 μg/L and low limits of detection (LODs) between 0.08 and 0.1 μg/L. Moreover, practical applications in real water samples confirmed the outstanding enrichment performance of COP-99@DCA. At spiked concentrations of 5 and 10 μg/L, the recovery rates were 85.35–113.55% and 92.17–110.46%, respectively. These results demonstrate the great potential of COP-99@DCA for practical water sample analysis. Collectively, these findings provide a novel strategy for the design of pre-treatment materials for the analysis of trace organic pollutants. Full article
(This article belongs to the Special Issue (Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers)
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Review

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28 pages, 1997 KB  
Review
Sensor Technologies in Medicine–Food Homology: A Comprehensive Review
by Yifan Qi, Shuwen Yan, Jianrong Chai, Tingrui Wang and Yuming Wang
Chemosensors 2026, 14(4), 95; https://doi.org/10.3390/chemosensors14040095 - 13 Apr 2026
Viewed by 773
Abstract
Medicine–food homology (MFH) substances, which possess both medicinal and edible properties, have garnered widespread attention in the global health context of the new era. The MFH industry has experienced explosive growth and has gradually become a key supporting aspect of TCM modernization. However, [...] Read more.
Medicine–food homology (MFH) substances, which possess both medicinal and edible properties, have garnered widespread attention in the global health context of the new era. The MFH industry has experienced explosive growth and has gradually become a key supporting aspect of TCM modernization. However, due to the pollution of the modern environment, the content of pollutants in MFH products has been increasing, raising concerns regarding quality, safety, and efficacy control. Traditional quality-analysis technologies struggle to meet the needs of rapid on-site detection because of their dependence on large instruments and the complexity of operation. This dilemma has propelled advances in sensor technology. With its advantages of high sensitivity, real-time detection, and portability, sensor technology has become a key technical support for quality control and supervision in the field of MFH. In this review, we comprehensively categorize the mainstream sensor types used for analysis in the field of MFH, including intelligent sensors, optics, electrochemistry, biosensors, etc. This review outlines their research status, elaborates on their primary application directions and corresponding core technologies, discusses current challenges (including stability, interference, and cost), and presents future perspectives. Overall, sensor-based technologies offer a promising and scalable solution for the quality control of MFH products, addressing critical challenges such as stability, interference, and cost. With ongoing advances in intelligent sensing, optics, electrochemistry, and biosensing platforms, these methods are poised to play an increasingly vital role in ensuring the safety, efficacy, and quality consistency of MFH products amid growing environmental pressures. Full article
(This article belongs to the Special Issue (Bio)Chemical Sensing in Real-World Applications—a Dedicated Issue for Young Researchers)
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