Special Issue "New Technologies Based on Stem Cell-Therapies in Regenerative Medicine and Reproductive Biology"
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 6401
Interests: stem cells; anti-aging; male infertility; reproductive immunology
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The issue is intended to address the background of modern technology of stem cell identification in respect of optimal candidates used to treat respective diseases. This will include in vitro propagation and identification of stem cells derived from tissue reservoirs, the creation of personally tailored cells out of somatic cells through induced pluripotential state (iPS), and re-differentiation into stem cell precursor-progenitor pool, genetic modifications of stem cells to increase desired capacities as. pro-angiogenic, pro-regenerative, anti-inflammatory, anti-fibrotic genes. This would include all technicalities of genes introduction (transient versus stable gene overexpression), optimization of promoters, vectors, and imaging systems (molecular probes singular/double). Personally tailored own stem cells through iPS technology would include genetic overexpression, epigenetic strategy, mRNA (including small regulatory molecules), proteins, and small chemical molecules (methylation vs demethylation). Cell re-differentiation would include cocktails of growth factors, media components, artificial intelligence automatic systems, accelerated in vitro cell maturation (specifically in case of muscular components including skeletal muscles and heart as well as cells of central nervous system). Stem cell delivery is connected with stem cell monitoring of migratory routes and transitions including novel instrumentation of live in situ tracking systems, endoscopy, ultrasound, isotopic and non-isotopic ways of detection. Stem cell retention in target organs would require chaperones for the other accompanying stem/progenitor cells, gradient creation when using interplay of receptors with chemokine attraction molecules, adjuvating medicines provided by nanotechnological means as nanocapsules with self-degrading properties and resistant to a pro-inflammatory milieu while demonstrating stimulating properties to stem cells action. Moreover, papers that outline materials, nano-materials and scaffolds in combination with both cell retention issues as well as adaptation to microenvironment and organ specificity are welcome. We seek papers on immunomodulatory properties towards stem cell, acceptance in immunoprivileged sites as a part of protocols optimization depending on demand of target organ. Finally, we are looking for papers on organoids from the future perspective of stem cell technology and 3-D organ architecture to finish a futuristic view of organ replacement.
Prof. Dr. Maciej Kurpisz
Manuscript Submission Information
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- Stem cell tissue reservoir
- Personally tailored stem cell interventions
- Stem cell genetic modifications
- Molecular reporters and cell tracking
- Cell delivery and organ retention
- Nanotechnological means to support stem cells action