DOCK Proteins in Mammalian Physiology and Disease

Dear Colleagues,

The Ras superfamily of GTP-binding proteins influences a very wide range of developmental, homeostatic and pathobiological processes in mammals and lower organisms. The activation of most Ras-like proteins is potently facilitated by guanine nucleotide exchange factors (GEFs) which promote exchange of GDP for GTP. The Ras superfamily consists of the Arf, Ran, Rab, Ras, and Rho branches. For the Rho branch, two structurally highly distinct classes of GEFs exist: Dbl (diffuse B-cell lymphoma) and DOCK (dedicator of cytokinesis). Initially, Dbl proteins received much attention for the simple reason that they were discovered earlier than DOCKs. However, DOCK proteins have since taken on substantial importance. DOCKs serve as GEFs for the Cdc42 and Rac GTPases and comprise a total of 11 members divided into four subfamilies, A–D, based on structural similarity and substrate preference.

This upcoming Special Issue of Cells will provide an overview of the profound impact that individual DOCKs exert on mammalian physiology and disease.

Dr. Steen H. Hansen
Guest Editor

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