Special Issue "DNA Repair Defects and Telomere Dysfunction in Diseases"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (28 February 2017).
Interests: telomeres and telomerase; DNA damage and repair; toxicogenomics and environmental toxicology; radiation biology; experimental therapeutics; occupational and environmental health
Faithful transmission of genetic material to the next generation is one of the primary objectives of an organism. This should be attained despite the constant damage induced by endogenous and environmental agents on DNA. Evolution has invested in DNA repair mechanisms to combat the incurred DNA damage. These repair mechanisms are biologically significant in maintaining genome integrity and in turn to prevent diverse human diseases. In effective protection from DNA damage may lead to genetic instability as well. Genome instability is a hallmark of cancer cells, but are also a cause of genetic diseases in humans. Patients with genome instability/chromosome breakage syndromes show reduced DNA repair and higher disease prevalence. Telomeres have special roles in protecting the chromosomes as well as genome integrity. Telomere function may have contrasting consequences—inducing replicative senescence or promoting tumorigenesis. The roles may vary between cell types, depending on the expression of telomerase enzyme, the level of mutations present, the efficiency or deficiency of related DNA repair pathways and oxidative stress levels in the cell milieu. Telomeropathies are an emerging spectrum of human disorders, which exhibit telomere related defects. Improving our understanding of these mechanisms may provide new avenues for disease management.
This Special Issue provides the platform to publish original research as well as review articles in an Open Access format in the exciting crossroad between DNA repair and telomere dynamics. We aim for a comprehensive collection of articles, which cover either of the topics, DNA damage response/repair and/or telomere function, with special reference to human health and diseases. Studies on other models are also welcome. Articles on molecular mechanisms and the targeting of either of these pathways in theranostics would also be of major interest.
Dr. Prakash Hande
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- genome stability
- DNA damage
- DNA repair
- DNA repair defect and human diseases
- premature ageing
- DNA repair inhibition
- telomeres and telomerase
- telomere dysfunction and human diseases
- chromosome instability syndromes