Cellular Senescence: Aging, Cancer and Injury

Dear Colleagues, 

Cellular senescence is one of the nine, often inter-related, hallmarks of ageing and is a major underlying contributor to age-associated diseases.

Senescence is activated in response to stress and characterized by a permanent cell cycle arrest, an active metabolic state and production of a pro-inflammatory senescence associated secretory phenotype. Accumulation of senescent cells will compromise tissue architecture, the ability of tissue to regenerate or to function properly and can have paracrine and systemic effects to drive chronic inflammation. However, cellular senescence can have beneficial effects for example to inhibit cell proliferation and is an essential component of wound healing.

Considerable effort, both academic and biotech, has been generated in the last decade to understand the biochemical underpinnings of this process and to develop drugs to remove or modulate senescent cells in the hope that they will ameliorate age-related diseases. These include drugs that result in the elimination of the senescent cells (called senolytics) or those that modulate the secreted inflammatory nature of the senescent cell (called senomorphics). This indeed is one of the most exciting frontiers in medical research, but needs a fuller understanding of the interaction of senescence with the other hallmarks of the ageing process, of the temporal development of cellular senescence and ageing, and its influence on initiation and progress of disease.

The current Special Issue will focus on the newest developments of senescence with special emphasis on its impact in ageing, cancer and injury.

Prof. Dr. Mathew Vadas
Prof. Dr. Jennifer Gamble
Guest Editors

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• cellular senescence
• ageing
• inflammation
• therapeutics