Adenine Nucleotide Signaling and Modulation of the Immune Response
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 419
Special Issue Editor
Special Issue Information
Dear Colleagues,
Besides their well-known roles in energy metabolism, adenine nucleotides and nucleosides (AN) are essential and ubiquitous signaling molecules that mediate cellular communication. Extracellular AN act as signaling molecules that coordinate the functions of diverse cell types within tissues, a concept known as purinergic signaling. Inside cells, AN are important second messengers that translate external stimuli into cellular responses, e.g. by regulating cytosolic calcium levels in T lymphocytes in response to engagement of the T cell receptor.
This Special Issue focuses on the role of AN in modulating inflammation, i.e. the reaction of the immune system to perceived danger or damage to cells. Inflamed tissues contain high levels of extracellular ATP that is released from cells either as a consequence of cellular damage or by regulated release mechanisms. While extracellular ATP exerts largely pro-inflammatory effects by acting on P2X or P2Y receptors, it is quickly hydrolyzed by the concerted action of ectonucleotidases CD39 and CD73 to adenosine (ADO), which acts on P1 purinergic receptors to exert largely anti-inflammatory effects. Thus the balance between extracellular ATP and ADO provides an important mechanism regulating the degree of inflammation within a tissue. Still, many issues remain unresolved. Among them: the mechanisms and kinetics of ATP release by different cells, the identity and cellular distribution of ectoenzymes involved in the conversion of ATP to ADO. Is NAD+ released from cells in a similar fashion as ATP, and does it also contribute to purinergic signaling? How do different intracellular AN cooperate to shape cytosolic calcium responses to TCR signaling?
Corresponding to their central role in cellular communication, many pathologic conditions such as neuroinflammation, viral infections, and chronic metabolic inflammation are associated with alterations in AN signaling. In view of the easy accessibility of their players outside of cells this makes AN signaling cascades prime targets for therapeutic intervention.
Prof. Dr. Friedrich Haag
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Prof. Dr. Friedrich Haag
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- purinergic signaling
- extracellular ATP and adenosine
- calcium signaling
- ectonucleotidases CD39 and CD73
- nanobodies as inhibitors of adenine nucleotide signaling
- TCR signaling
- T cell differentiation
- chronic inflammation
- neuroinflammation
- viral infections
