Stem and Progenitor Cells in Kidney Repair and Regeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 355
Special Issue Editor
Interests: development; pattern formation; organogenesis; regeneration; stem cell biology; nephrogenesis; hematopoiesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Regeneration has captured our imagination for hundreds of years. The phenomenal ability of many animals to restore complex body parts with desirable growth that perfectly replaces them after an injury is astounding because humans lack many of these same powers. The advent of molecular genetics in recent decades has provided scientists with sophisticated tools to decipher the underlying mechanisms for this living magic. Nevertheless, it has been no easy task to solve the long-standing puzzles of regeneration.
The kidney is one of the most complex organs in animals regarding the diverse cellular composition of its nephron functional units and the intricate architecture of nephron arrangements. While humans have limited abilities to repair and regenerate their kidneys, other species ranging from invertebrates, such as the fly, to lower vertebrates, such as goldfish and zebrafish, to mammals, including the spiny mouse, exhibit surprising traits that regenerate their kidney tissue. Among these feats is the ability to undergo neonephrogenesis or the production of new nephrons after completed development from the endogenous renal stem and progenitor cells. In this Special Issue, we invite research contributions that examine the mechanisms of renal regeneration feats across metazoans.
Dr. Rebecca A. Wingert
Guest Editor
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Keywords
- kidney
- renal stem cell
- renal progenitor
- nephron
- neonephrogenesis
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